Abstract
Transgenic mice expressing the EBV latent membrane protein LMP demonstrate epithelial cell hyperplasia. LMP has also been shown to inhibit the terminal differentiation of human epithelial cells in vitro. Psoriasis is a human skin condition involving epithelial cell hyperplasia which histologically resembles LMP-transgenic skin. Psoriasis involves an increase in the thickness of the proliferative layer and a decrease in keratinisation and differentiation. Further the high levels of a number of growth factors produced in psoriatic skin could potentially provide an ideal environment for virus gene expression, virus transformation and virus productive replication. We are investigating the possibility that EBV may be involved in human psoriasis.
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© 1991 Springer Science+Business Media New York
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Rooney, C.M., Baker, B.S. (1991). Patients with Psoriasis Have High Serum Reactivity with EBNA-2B. In: Ablashi, D.V., Huang, A.T., Pagano, J.S., Pearson, G.R., Yang, C.S., Ablashi, K.L. (eds) Epstein-Barr Virus and Human Disease · 1990. Experimental Biology and Medicine, vol 24. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0405-3_44
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DOI: https://doi.org/10.1007/978-1-4612-0405-3_44
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4612-6747-8
Online ISBN: 978-1-4612-0405-3
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