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Replication of the Epstein-Barr Virus in Lymphoid and Epithelial Cells

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Book cover Epstein-Barr Virus and Human Disease · 1990

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 24))

Abstract

Evidence of limited viral replication has been detected in many infected tissues including specimens of nasopharyngeal carcinoma (NPC), lymphoproliferative syndrome, and some lymphoma tissue [1,2]. In the nonreplicative phase of infection, intracellular EBV DNA exists as an covalentlyclosed circular (ccc) episome. After induction of replication, the episomal DNA seems to serve as template for generation of the linear, virion DNA, which is synthesized by a viral-specific DNA polymerase, in contrast to the episomal form which is maintained by the cellular DNA polymerase [3].

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Author information

Authors and Affiliations

  1. Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, NC, USA

    Nancy Raab-Traub & Kevin Gilligan

  2. Kanazawa University, Kanazawa, Japan

    Hiroshi Sato & Toru Takimoto

  3. University of Malaya, Kuala Lumpur, Malaysia

    Pathmanathan Rajadurai

Authors
  1. Nancy Raab-Traub
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  2. Hiroshi Sato
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  3. Kevin Gilligan
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  4. Pathmanathan Rajadurai
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  5. Toru Takimoto
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Editor information

D. V. Ablashi A. T. Huang J. S. Pagano G. R. Pearson C. S. Yang Kristinë L. Ablashi

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© 1991 Springer Science+Business Media New York

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Raab-Traub, N., Sato, H., Gilligan, K., Rajadurai, P., Takimoto, T. (1991). Replication of the Epstein-Barr Virus in Lymphoid and Epithelial Cells. In: Ablashi, D.V., Huang, A.T., Pagano, J.S., Pearson, G.R., Yang, C.S., Ablashi, K.L. (eds) Epstein-Barr Virus and Human Disease · 1990. Experimental Biology and Medicine, vol 24. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0405-3_1

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  • DOI: https://doi.org/10.1007/978-1-4612-0405-3_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6747-8

  • Online ISBN: 978-1-4612-0405-3

  • eBook Packages: Springer Book Archive

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