Myogenic Properties of Blood Vessels In Vitro

  • George Osol
Part of the Vascular Biomedicine book series (VB)


It would be a disservice to begin a chapter on the myogenic behavior of blood vessels in vitro without describing the work of Sir William Bayliss almost 90 years ago. Using primitive recording techniques (a smoked drum), he removed a carotid artery from the neck of a dog three hours after asphyxiation, cannulated one end, tied off the other, and filled the segment with defibrinated blood. The preparation was connected to a mercury manometer and, when pressure was elevated, the vessel underwent a powerful contraction and “appeared to writhe like a worm.” Decreasing the pressure produced “considerable relaxation.” Unfortunately, the experimental detail is scant and we have no quantitative measure of the response because, in Bayliss’ words, “I regret that the tracing was spoilt in varnishing, so that I am unable to reproduce it here.”1 Nonetheless, Bayliss’ observation captures the quintessence of myogenic theory as it applies to vascular behavior—pressure orstretch-induced activation of smooth muscle cells that leads to a decrease in arterial diameter.


Vascular Smooth Muscle Transmural Pressure Internal Elastic Lamina Arterial Diameter Basal Tone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bayliss, W. M. (1902) J. Physiol. 28, 220–231.PubMedGoogle Scholar
  2. 2.
    Garfield, E. (1976) Curr. Contents 19, 5.Google Scholar
  3. 3.
    Folkow, F. (1964) Circ. Res. 15(Suppl. I), 279–287.PubMedGoogle Scholar
  4. 4.
    Koch, A. R. (1964) Circ. Res.14(Suppl. I), 269–277.Google Scholar
  5. 5.
    Borgstrom, P., Grande, P.O., and Mellander, S. (1982) Acta Physiol. Scand. 116,363–376.PubMedCrossRefGoogle Scholar
  6. 6.
    Lush, D. L. and Fray, J. C. S. (1984) Am. J. Physiol. 247, R89–R99.PubMedGoogle Scholar
  7. 7.
    Johnson, P. C. (1980) Handbook of Physiology, Section 2: The Cardiovascular System, vol. 2: Vascular Smooth Muscle, (Bohr, D. F., Somlyo, A. P., and Sparks, H. V. J. Jr., eds.), American Physiological Society, Bethesda, MD, pp. 409–442.Google Scholar
  8. 8.
    Johnson, P. C. (1986) Circ. Res. 59,483–495.PubMedCrossRefGoogle Scholar
  9. 9.
    Heistad, D. D. and Kontos, H. A. (1983) Handbook of Physiology, Section 2: The Cardiovascular System, vol. 3,Peripheral Circulation and Organ Blood Flow, Part 2 (Shepherd, J. T. and Abboud, F. M., eds.), American Physiological Society, Bethesda, MD, pp. 137–182.Google Scholar
  10. 10.
    Bohlen, H. G. and Gore, R. W. (1977) Microvasc. Res. 14,251–264.PubMedCrossRefGoogle Scholar
  11. 11.
    Johansson, B. and Mellander, S. (1975) Circ. Res. 36, 76–83.PubMedCrossRefGoogle Scholar
  12. 12.
    Laher, I. and Bevan, J. A. (1989) J. Hypertens. 7(Suppl. 4), S17–S20.Google Scholar
  13. 13.
    Johanson, B. (1989)1. Hypertens. (Suppl. 4), S5–S8.Google Scholar
  14. 14.
    Sparks, H. V. (1964) Circ. Res. 14 (Supp1. I), 254–260.Google Scholar
  15. 15.
    Nakayama, K. (1982) Am. J. Physiol. 242, H760–H768.PubMedGoogle Scholar
  16. 16.
    Bevan, J. A. (1982) Am. J. Cardiol. 49, 519–524.PubMedCrossRefGoogle Scholar
  17. 17.
    Laher, I., van Breemen, C., and Bevan, J. A. (1988) Circ. Res. 63,669–672.PubMedCrossRefGoogle Scholar
  18. 18.
    Bevan, J. A. and Hwa, J. J. (1985) Ann. Biomed. Eng. 13, 281–286.PubMedCrossRefGoogle Scholar
  19. 19.
    Katusic, Z. S., Shepherd, J. T., and Vanhoutte, P. M. (1987) Am. J. Physiol. 252, H671–H673.Google Scholar
  20. 28.
    Uchida, E., Bohr, D. F., and Hoobler, S. W. (1967) Circ. Res. 21,525–536.PubMedCrossRefGoogle Scholar
  21. 21.
    Duling, B. R., Gore, R. W., Dacey, R. G., and Damon, D. N. (1981) Am. J. Physiol. 241, H108–H116.PubMedGoogle Scholar
  22. 22.
    Davignon, J., Lorenz, R. R., and Shepherd, J. T. (1963) Am. J. Physiol. 209, 51–59.Google Scholar
  23. 23.
    Halpern, W., Osol, G., and Coy, G. S. (1984) Ann. Biomed. Eng. 12, 463–479.PubMedCrossRefGoogle Scholar
  24. 24.
    Harder, D. R., Smeda, J., and Lombard, J. (1985) Circ. Res. 57, 319–322.PubMedCrossRefGoogle Scholar
  25. 25.
    Uchida, E. and Bohr, D. F. (1969) Circ. Res. 25,549–555.PubMedCrossRefGoogle Scholar
  26. 26.
    Osol, G. and Halpern, W. (1985) Am. J. Physiol. 249, H914–H921.Google Scholar
  27. 27.
    Vinall, P. E. and Simeone, F. A. (1981) Stroke 12,640–642.PubMedCrossRefGoogle Scholar
  28. 28.
    Kuo, L., Chilian, W. M., and Davis, M. J. (1990) Circ. Res. 66,860–866.PubMedCrossRefGoogle Scholar
  29. 29.
    Osol, G. and Halpern, W. (1988) Am. J. Physiol. 254, H28–H33.PubMedGoogle Scholar
  30. 30.
    Osol, G., Osol, R., and Halpern, W. (1986) in Essential Hypertension: Cal-cium Mechanisms and Treatment(Aoki, K., ed.), Springer-Verlag, Tokyo,pp. 107 114.Google Scholar
  31. 31.
    Nakayama, K., Suzuki, S., and Sugi, H. (1986) Jpn. J. Pysiol. 36, 745–760.CrossRefGoogle Scholar
  32. 32.
    Davis, M. J. and Burch, L. M (1989) FASEB J. 3, A1383.Google Scholar
  33. 33.
    Johansson, B. and Bohr, D. F. (1966) Am. J. Physiol. 210, 801–806.PubMedGoogle Scholar
  34. 34.
    Holman, M. E., Dasby, C. B., Suthers, M. B., and Wilson, J. A. F. (1968) 1. Physiol. (Lond.) 196, 111–132.Google Scholar
  35. 35.
    Nelson, M. T., Standen, N. B., Brayden, J. B., and Worley, J. F. (1988) Nature 336,382–385.PubMedCrossRefGoogle Scholar
  36. 36.
    Smeda, J. S., Lombard, J. H., Madden, J. A., and Harder, D. R. (1987) Pflugers Arch. 408,239–242.PubMedCrossRefGoogle Scholar
  37. 37.
    Harder, D. R. (1984) Circ. Res. 55,197–202.PubMedCrossRefGoogle Scholar
  38. 38.
    Harder, D. R., Brann, L., and Halpern, W. (1983) Blood Vessels 20, 154–160.PubMedGoogle Scholar
  39. 39.
    Hwa, J. J. and Bevan, J. A. (1986) Am. J. Phusiol. 250, H87–H95.Google Scholar
  40. 40.
    Rosenblum, W. I. and Nelson, G. H. (1988) Stroke 19,1379–1382.PubMedCrossRefGoogle Scholar
  41. 41.
    McCarron, G., Osol, R., and Halpern, W. (1989) Blood Vessels 26, 315–319.PubMedGoogle Scholar
  42. 42.
    Osol, G., Osol, R., and Halpern, W. (1988) Resistance Arteries (Halpern, W., Pegram, B. L., Brayden, J. E., Mackey, K., McLaughlin, M. K., and Osol, G., eds.), Perinatology, Ithaca, NY, pp. 162–169.Google Scholar
  43. 43.
    Olesen, S.-P., Clapham, D. E., and Davies, P. F. (1988) Nature 311, 168–170.CrossRefGoogle Scholar
  44. 44.
    Pohl, U., Forstermann, U., Busse, R., and Bassenge, E. (1985) Prostaglandins and Other Eicosanoids in the Cardiovascular System. Proc. 2nd Int. Symp. (Schor, ed.), Nurnberg-Furth, Karger, Basel, pp. 553–558.Google Scholar
  45. 45.
    Frangos, J. A., Eskin, S. G., McIntire, L. V., and Ives, C. L. (1985) Science 227,1477–1478.PubMedCrossRefGoogle Scholar
  46. 46.
    Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., and Masald, T. (1988) Nature 332, 411–415.PubMedCrossRefGoogle Scholar
  47. 47.
    Harder, D. R. (1987) Circ. Res. 60,102–107.PubMedCrossRefGoogle Scholar
  48. 48.
    Kauser, K., Stekiel, W. J., Ruganyi, G., and Harder, D. R. (1989) Circ. Res. 65,199–204.PubMedCrossRefGoogle Scholar
  49. 49.
    Rubanyi, G. M. (1988) Am. J. Physiol. 255, H783–H788.Google Scholar
  50. 50.
    Tesfamariam, B., Halpern, W., and Osol, G. (1985) Blood Vessels 22, 301–305.PubMedGoogle Scholar
  51. 51.
    Osol, G., Cipolla, M., and Knutson, S. (1989) Blood Vessels 26, 320–324.PubMedGoogle Scholar
  52. 52.
    Osol, G., Cipolla, M., and Osol, R. (1990) Blood Vessels 27, 51.Google Scholar
  53. 53.
    Mills, I., Letsou, G., Sumpio, B., and Gewirtz, H. (1989) Circulation 80 (Suppl. II), II-197.Google Scholar
  54. 54.
    Watson, P. (1990) J. Biol. Chem. 265, 6569–6575.PubMedGoogle Scholar
  55. 55.
    Laher, I. and Bevan, J. A. (1987) J. Pharmacol. Exp. Ther. 242, 566–572.PubMedGoogle Scholar
  56. 56.
    Laher, I., Vorkapic, P., Dowd, A., and Bevan, J. A. (1989) Biochem. Biophys. Res. Commun. 165,312--318. PubMedCrossRefGoogle Scholar
  57. 57.
    Osol, G., Laher, I., and Cipolla, M. (1991) Circ. Res. 68, 359–367.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • George Osol

There are no affiliations available

Personalised recommendations