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Neural Control of Resistance Arteries

  • Tim O. Neild
  • Joseph E. Brayden
Part of the Vascular Biomedicine book series (VB)

Abstract

Information on the effects of vasoconstrictor nerves on resistance vessels has come from studies on intact vascular beds and isolated resistance arteries. It was from studies on the resistance of vascular beds that it first became dear that most resistance arteries must receive a vasoconstrictor innervation from the sympathetic nervous system. Following the discovery that norepinephrine was released by sympathetic nerves, many workers showed that antagonists of the action of norepinephrine on vascular smooth muscle also greatly reduced the effect of sympathetic nerves on the resistance of vascular beds. There seemed to be no reason to doubt that norepinephrine was the sympathetic neurotransmitter in this situation. However, studies on the vas deferens, which has many properties in common with arteries, led some workers to question whether norepinephrine was the neurotransmitter. This doubt spread to the field of resistance arteries, and the controversy is still not settled. Indeed, it has been complicated by the realization that the sympathetic nerves are capable of releasing neuropeptide Y (NPY) and perhaps ATP, in addition to norepinephrine.

Keywords

Sympathetic Nerve Vasoactive Intestinal Polypeptide Large Artery Resistance Vessel Resistance Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Tim O. Neild
  • Joseph E. Brayden

There are no affiliations available

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