Neural Control of Resistance Arteries

  • Tim O. Neild
  • Joseph E. Brayden
Part of the Vascular Biomedicine book series (VB)


Information on the effects of vasoconstrictor nerves on resistance vessels has come from studies on intact vascular beds and isolated resistance arteries. It was from studies on the resistance of vascular beds that it first became dear that most resistance arteries must receive a vasoconstrictor innervation from the sympathetic nervous system. Following the discovery that norepinephrine was released by sympathetic nerves, many workers showed that antagonists of the action of norepinephrine on vascular smooth muscle also greatly reduced the effect of sympathetic nerves on the resistance of vascular beds. There seemed to be no reason to doubt that norepinephrine was the sympathetic neurotransmitter in this situation. However, studies on the vas deferens, which has many properties in common with arteries, led some workers to question whether norepinephrine was the neurotransmitter. This doubt spread to the field of resistance arteries, and the controversy is still not settled. Indeed, it has been complicated by the realization that the sympathetic nerves are capable of releasing neuropeptide Y (NPY) and perhaps ATP, in addition to norepinephrine.


Sympathetic Nerve Vasoactive Intestinal Polypeptide Large Artery Resistance Vessel Resistance Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Owen, M. P., Quinn, C., and Bevan, J. A. (1985) Am. J. Physiol. 249, H404–H414.PubMedGoogle Scholar
  2. 2.
    Faber, J. E. (1988) Circ. Res. 62, 37–50.PubMedCrossRefGoogle Scholar
  3. 3.
    Nilsson, H. (1984) Acta Physiol. Scand. 121, 353–361.PubMedCrossRefGoogle Scholar
  4. 4.
    Mulvany, M. J., Nilsson, H., and Flatman, J. A. (1982) J. Physiol. 332, 363–373.PubMedGoogle Scholar
  5. 5.
    Neild, T. O. and Kotecha, N. (1989) Microvasc. Res. 38,186–199.PubMedCrossRefGoogle Scholar
  6. 6.
    Furness, J. B. and Marshall, J. M. (1974) J. Physiol. 239,75–88.PubMedGoogle Scholar
  7. 7.
    Altura, B. M. (1984) Microvasc. Res. 3,361–384.CrossRefGoogle Scholar
  8. 8.
    Docherty, J. R. and McGrath, J. C. (1980) Naunyn-Schmiedeberg’s Arch. Pharmacol. 312,107–116.CrossRefGoogle Scholar
  9. 9.
    Goadsby, P. J., Lambert, G. A., and Lance, J. W. (1985) Brain Res. 326, 213–217.PubMedCrossRefGoogle Scholar
  10. 10.
    Heusch, G., Deussen, A., Schipke, J., and Thamer, V. (1984)1. Cardiovasc. Pharmacol. 69,61–68.Google Scholar
  11. 11.
    Faber, J. E. and McGillivray, K. M. (1988) Resistance Arteries (Halpern, W., Pegram, B. L., Brayden, J. E., Mackey, K., McLaughlin, M. K., and Osol, G., eds.) Perinatology, Ithaca, NY, pp. 19–128.Google Scholar
  12. 12.
    Morgan, K. G. (1983) Am. J. Physiol. 244, H540–H545.PubMedGoogle Scholar
  13. 13.
    Hirst, G. D. S. and Neild, T. O. (1981) J. Physiol. 313,343–350.PubMedGoogle Scholar
  14. 14.
    Laher, L., Nishimura, S., Bevan, J. A. (1986) J. Pharmacol. Exp. Ther. 239, 846–852.PubMedGoogle Scholar
  15. 15.
    Hirst, G. D. S. and Lew, M. J. (1987) Brit. J. Pharmacol. 90,51–60.CrossRefGoogle Scholar
  16. 16.
    Angus, J. A., Broughton, A., and Mulvany, M. J. (1988) J. Physiol. 403, 495–510.PubMedGoogle Scholar
  17. 17.
    Janig, W. (1988) Ann. Rev. Physiol. 50, 525–539.CrossRefGoogle Scholar
  18. 18.
    Hirst, G. D. S., De Glaria, S., and van Helden, D. F (1985) Experientia 41, 874–879.PubMedCrossRefGoogle Scholar
  19. 19.
    Holman, M. E. and Surprenant, A. (1980) Br. J. Pharmacol. 71, 651–661.PubMedCrossRefGoogle Scholar
  20. 20.
    Ambache, N. and Zar, M. A. (1971)1. Physiol. 216, 359–389.PubMedGoogle Scholar
  21. 21.
    vonEuler, U. S. and Hedqvist, P. (1975) Acta Physiol. Scand. 93,572–573.CrossRefGoogle Scholar
  22. 22.
    McGrath, J. C. (1980) Nature 288,301–302.PubMedCrossRefGoogle Scholar
  23. 23.
    Sneddon, P. and Westfall, D. P. (1984) J. Physiol. 347,561–580.PubMedGoogle Scholar
  24. 24.
    Sneddon, P., Westfall, D. P., and Fedan, J. S. (1982) Science 218, 693–694.PubMedCrossRefGoogle Scholar
  25. 25.
    Sneddon, P. and Burnstock, G. (1984) Eur. J. Pharmaco1.106,149–152. CrossRefGoogle Scholar
  26. 26.
    Kugelgen, I. V. and Starke, K. (1985) Physiol. 367,435–455.Google Scholar
  27. 27.
    Byrne, N. G. and Large, W. A. (1986) Br. J. Pharmacol. 88, 6–8.Google Scholar
  28. 28.
    Edwards, F. R., Hards, D., Hirst, G. D. S., and Silverberg, G. D. (1989) Br. J. Pharmacol. 96, 785–788.PubMedCrossRefGoogle Scholar
  29. 29.
    Buhrle, C. P., Scholz, H., Nobiling, R., and Taugner, R. (1986) Pflugers Arch. 406,578–586.PubMedCrossRefGoogle Scholar
  30. 30.
    Freid, G., Langercrantz, H., Klein, R, and Thureson-Klein, A. (1984) Cate-cholamines,Basic and Peripheral Mechanisms, (Usdin, B., Carlsson, A.,Dahlstrom, S., and Eagel, M., eds.), Liss, New York, pp. 45–53.Google Scholar
  31. 31.
    Morris, J. L., Gibbins, I. L., and Murphy, R. (1986) Neuroscience Letters 71, 264–270.PubMedCrossRefGoogle Scholar
  32. 32.
    Morris, J. L. and Murphy, R. (1988)1. Auton. Nerv. Syst. 24,241–249.PubMedCrossRefGoogle Scholar
  33. 33.
    Potter, E. K. (1988) Phamac. Ther. 37,251–273.CrossRefGoogle Scholar
  34. 34.
    Gibbins, I. L. and Morris, J. L. (1990)1. Auton. Nerv. Syst. 29,137–150.PubMedCrossRefGoogle Scholar
  35. 35.
    Owen, M. P. and Taphorn, M. C. (1988) Resistance Arteries, Halpern, W., Pegram, B. L., Brayden, J. E., Mackey, K., McLaughlin, M. K., and Osol, G., eds.) Perinatology, Ithaca, NY, pp. 74–79.Google Scholar
  36. 36.
    Edvinsson, L., Emson, P., McCulloch, J., Tatemoto, K., and Uddman, R. (1984) Acta Physiol. Scand. 122,155–163.PubMedCrossRefGoogle Scholar
  37. 37.
    Brayden, J. E. and Conway, M. A. (1988) Regul. Pept. 22,253–265.PubMedCrossRefGoogle Scholar
  38. 38.
    Neild, T. O. and Kotecha, N. (1990) J. Auton. Nerv. Syst. 30,29–36.PubMedCrossRefGoogle Scholar
  39. 39.
    Hirst, G. D. S. and Edwards, F. R (1988) Physiol. Rev. 69,546–604.Google Scholar
  40. 40.
    Hirst, G. D. S. (1977) J. Physiol. 273,263–275.PubMedGoogle Scholar
  41. 41.
    Hirst, G. D. S., Silverberg, G. D., and VanHelden, D. F. (1986)1. Physiol. 371,289–304.PubMedGoogle Scholar
  42. 42.
    Bolton, T. B., Lang, R. J., and Takewaki, T. (1984) J. Physiol. 351,549–572.PubMedGoogle Scholar
  43. 43.
    Neild, T. O. and Keef, K. (1985) Microvasc. Res. 30,19–28.PubMedCrossRefGoogle Scholar
  44. 44.
    Bolton, T. B. and Large, W. A. (1986) J. Exp. Physiol. 71,1–28.Google Scholar
  45. 45.
    Neild, T. O. (1984) Proc. Roy. Soc. B. 220,237–249.CrossRefGoogle Scholar
  46. 46.
    Speden, R. N. (1964) Nature 202,193–194.PubMedCrossRefGoogle Scholar
  47. 47.
    Steedman, W. M. (1966) J. Physiol. 186, 382–400.PubMedGoogle Scholar
  48. 48.
    Cohen, R. A., Shepherd, J. T., and Vanhoutte, P. M. (1984)1. Pharmacol. Exp. Ther. 229,417–421.PubMedGoogle Scholar
  49. 49.
    Bevan, J. A. and Brayden, J. E. (1987) Circ. Res. 60,309–326. 50 Florence, V. M. and Bevan, J. A. (1979) Circ. Res. 45,212–218.PubMedCrossRefGoogle Scholar
  50. 50.
    Florence,V. M. and Bevan,I.A (1979) Cire. Res.45,212–218.CrossRefGoogle Scholar
  51. 51.
    Duckles, S. P. (1981) J. Pharmacol. Exp. Ther. 217,544–548.Google Scholar
  52. 52.
    Bevan, J. A., Buga, G. M., Jope, C. A., Jope, R. S., and Moritoki, H., (1982) Circ. Res. 51, 421–429.PubMedCrossRefGoogle Scholar
  53. 53.
    Hamel, E., Assumel-Lurdin, C., Edvinsson, L., and MacKenzie, E. T. (1986) Acta Physiol. Scand. 127 (Suppl. 552), 13–16.Google Scholar
  54. 54.
    Hamel, E., Assumel-Lurdin, C., Edvinsson, L., Fage, D., and MacKenzie, E. T. (1987) Brain Res. 420,391–396.PubMedCrossRefGoogle Scholar
  55. 55.
    Arneric, S. P., Iadecola, C., Underwood, M. D., and Reis, D. J. (1987) Brain Res. 411, 212–225.PubMedCrossRefGoogle Scholar
  56. 56.
    Shimon, M., Egozi, Y., Kloog, Y., Sokolovsky, M., and Cohen, S. J. (1988) Neurochem. 50,1719–1724.CrossRefGoogle Scholar
  57. 57.
    Saito, A., Wu, J.-Y., and Lee, T. J.-F. (1985) J. Cereb. Blood Flow Metab. 5, 327–334.PubMedCrossRefGoogle Scholar
  58. 58.
    Eckenstein, F. and Baughman, R. W. (1984) Nature 309,153–155.PubMedCrossRefGoogle Scholar
  59. 59.
    Armstrong, D. M. (1986) J. Comp. Neurol. 250,81–92.CrossRefGoogle Scholar
  60. 60.
    Bulbring, E. and Burn, J. H. (1936) J. Physiol. 87,254–274.PubMedGoogle Scholar
  61. 61.
    Feigl, E. O. (1969) Circ. Res. 25,509–519.PubMedCrossRefGoogle Scholar
  62. 62.
    Sanders, J. S., Mark, A. L., and Fergason, D. W. (1989) Circulation 79, 815–824.PubMedCrossRefGoogle Scholar
  63. 63.
    Iadecola, C., Underwood, M. D., and Reis, D. J. (1986) Brain Res. 368, 375–379.PubMedCrossRefGoogle Scholar
  64. 64.
    Andersson, P.O., Bloom, S. R., and Jarhult, J. (1983) J. Physiol. 334, 293–307.PubMedGoogle Scholar
  65. 65.
    Nandiwada, P. A., Hyman, A. L., and Kadowitz, P. J. (1983)Circ. Res. 53, 86–95.PubMedCrossRefGoogle Scholar
  66. 66.
    Lundberg, J. M. (1981) Acta Physiol. Scand. 112 (Suppl. 496), 157.CrossRefGoogle Scholar
  67. 67.
    Koo, A. and Liang, I. Y. S. (1979) J. Exp. Physiol. 64,149–159.Google Scholar
  68. 68.
    Neild, T. O., Shen, K. Z., and Surprenant, A. (1990) J. Physiol. 420, 247–265.PubMedGoogle Scholar
  69. 69.
    Brayden, J. E. and Bevan, J. A. (1985) Circ. Res. 56, 205–211.PubMedCrossRefGoogle Scholar
  70. 70.
    Brayden, J. E. and Large W. (1986) Br. J. Pharmacol. 89,163–171.PubMedCrossRefGoogle Scholar
  71. 71.
    Said, S. I. and Mutt, V. (1970) Science 169,1217–1218.PubMedCrossRefGoogle Scholar
  72. 72.
    Hokfelt, T., Schultzburg, M., Lundberg, J., Fuxe, K., Mutt, V., Fahrendrug, J., and Said, S. I. (1982) Vasoactive Intestinal Polypeptide (Said, S. I., ed.), Raven, New York, pp. 65–90.Google Scholar
  73. 73.
    Gibbins, I. L., Brayden, J. E., and Bevan, J. A. (1984) Neuroscience 13, 1327–1346.PubMedCrossRefGoogle Scholar
  74. 74.
    Della, N. G., Papka, R. E., Furness, J. B., and Costa M. (1983) Neuroscience 9, 605–619.PubMedCrossRefGoogle Scholar
  75. 75.
    Uddman, R., Alumets, J., Edvinsson, L, Hakanson, R., and Sundler, F. (1981) Acta Physiol. Scand. 112, 65–70.PubMedCrossRefGoogle Scholar
  76. 76.
    Lee, T. J.F. and Bevan, J. A. (1975) Experientia 31,1424–1425.PubMedCrossRefGoogle Scholar
  77. 77.
    Lee, T.J.F., Saito, A., and Berezin I. (1984) Sciencr 224, 898–901.CrossRefGoogle Scholar
  78. 78.
    Lundberg, J. M., Anggard, A., and Fahrenkrug, J. (1982) Acta Physiol. Scand. 116, 387–392.PubMedCrossRefGoogle Scholar
  79. 79.
    Lundberg, J. M., Anggard, A., Emson, P., Fahrenkrug, J., and Hokfelt, T. (1981) Proc. Natl. Acad. Sci. LISA 78, 5255–5259.CrossRefGoogle Scholar
  80. 80.
    Fahrenkrug, J. and Ottesen, B. (1982)1. Physiol. 331, 331–460.Google Scholar
  81. 81.
    Bloom, S. R. and Edwards, A. V. (1980) J. Physiol. 229, 437–452.Google Scholar
  82. 82.
    Bevan, J. A., Moskowitz, M., Said, S. I., and Buga, G. M. (1984) Peptides 5, 385–388.PubMedCrossRefGoogle Scholar
  83. 83.
    Brayden, J. E. and Bevan, J. A. (1986) Stroke 17,1189–1192.PubMedCrossRefGoogle Scholar
  84. 84.
    Edvinsson, L., McCulloch, Uddman, R. (1981) J. Physiol. 318, 251–258.PubMedGoogle Scholar
  85. 85.
    Furness, J. B., Papka, R. E., Della, N. G., Costa, M., and Eskay, R. L. (1982) Neuroscience 7, 447–459.PubMedCrossRefGoogle Scholar
  86. 86.
    Jessell, T. M., Iversen, L. L., and Cuello, A. C. (1978) Brain Res. 152, 183–188.PubMedCrossRefGoogle Scholar
  87. 87.
    Pernow, B. (1983) Pharmacol. Rev. 35, 85–141.PubMedGoogle Scholar
  88. 88.
    Lembeck, F. and Holzer, P. (1979) Naunyn-Schmiederberg’s Arch. Pharmacol. 310,175–183.CrossRefGoogle Scholar
  89. 89.
    Rosell, S., Olgart, L., Gazelius, B., Panopoulos, P., Folker, K., and Horig, J. (1981) Acta Physiol. Scand. 111, 381,382.Google Scholar
  90. 90.
    Lembeck, F., Donnerer, J., and Bartho, L. (1982) Eur. J. Pharmacol. 85, 171–176.PubMedCrossRefGoogle Scholar
  91. 91.
    Gazelius, B. and Olgart, L. (1980) Acta Physiol. Scand. 108, 181–186.PubMedCrossRefGoogle Scholar
  92. 92.
    Galligan, J. J., Ming-ming, Jiang, Sjen, K. Z., and Surprenant, A. (1990) J. Physiol. 420, 267–280.PubMedGoogle Scholar
  93. 93.
    Rosenfeld, M., Mermod, J., Amara, S., Swanson, L., Sawchenko, P. E., Rivier, J., Vale, W. W., and Evans, R. M. (1983) Nature 304,129–135.PubMedCrossRefGoogle Scholar
  94. 94.
    Uddman, R., Edvinsson, L., Ekblad, E., Hakanson, R., and Sundler, F. (1986) Reg. Peptides 15,1–23.CrossRefGoogle Scholar
  95. 95.
    Gibbins, I. L., Furness, J. B., Costa, M., Maclntyre, I., Hillyard, C. J., and Girgis, S. (1985) Neurosci. Lett. 57,125–130.PubMedCrossRefGoogle Scholar
  96. 96.
    Hanko, J., Hardebo, J. E., Kahrstrom, J., Owman, C., and Sundler, F. (1985) Neurosci. Lett. 57, 91–95.PubMedCrossRefGoogle Scholar
  97. 97.
    Edvinsson, L., Ekman, R., Jansen, I., McCulloch, J., and Uddman, R. (1987) J. Cer. Blood Flow Metab. 7, 720–728.CrossRefGoogle Scholar
  98. 98.
    Gulbenkian, S., Merighi, A., Wharton, J, Varndell, I. M., and Polak, J. M. (1986)1. Neurocytology 15, 535–542.CrossRefGoogle Scholar
  99. 99.
    Wharton, J., Gulbenkian, S., Mulderry, P., Ghatei, M., McGregor, G, Bloom, S. P., and Polak, J. (1986)1. Autonom. Nervous Syst. 16, 289–309.CrossRefGoogle Scholar
  100. 100.
    Kawasaki, H., Takasaki, K., Saito, A., and Goto K. (1988) Nature 335, 164–167.PubMedCrossRefGoogle Scholar
  101. 101.
    Fujimori, A., Saito, A., Kimura, S., Watanabe, T., Uchiyama, Y., Kawasaki, H., and Goto, K. (1989) Biochem. Biophys. Res. Comm. 165, 1391–1398.PubMedCrossRefGoogle Scholar
  102. 102.
    Han, S.-P., Naes, L., and Westfall, T. C. (1990)Biochem. Biophys. Res. Comm.168, 786–791.PubMedCrossRefGoogle Scholar
  103. 103.
    Bell, C.,Burnstock,G.,andGriffith, S. G., eds.(1988)Nonadrenergic In-nervation ofBlood Vessels, vol. 1.CRC Press, Boca Raton, FL, pp. 41–64.Google Scholar
  104. 104.
    Bell, C. and Gillespie, J. S. (1981) Neurochem. 36, 703–706.CrossRefGoogle Scholar
  105. 105.
    Bell, C., Lang, W., and Laska, F. (1978) J. Neurochem. 31, 77–83.PubMedCrossRefGoogle Scholar
  106. 106.
    Bell, C. and Muller, B. D. (1982) Neurosci. Lett. 31,31–35.PubMedCrossRefGoogle Scholar
  107. 107.
    Dinerstein, R. J., Vannice, J., Henderson, R. c., Roth, L., Goldberg, L. I.,and Hoffman, P. C. (1979) Science 205, 497–499.PubMedCrossRefGoogle Scholar
  108. 108.
    Nichols, A. J. and Hiley, C. R. (1985) J. Phann. Pharmacol. 37, 110–115.CrossRefGoogle Scholar
  109. 109.
    Toda, N. and Goldberg, L.1. (1973) J. Phann. Pharmacol. 25,587–589.CrossRefGoogle Scholar
  110. 110.
    Bell, C. and Lang, W.J. (1979) Br. J. Phann. 67,337–343.CrossRefGoogle Scholar
  111. 111.
    Lang, W.J, Bell, C., and Conway, F. L (1976) Circ. Res. 38,560–566.PubMedCrossRefGoogle Scholar
  112. 112.
    Bell, C. and Lang, W.J. (1973) Nature New BioI. 246,27–29.Google Scholar
  113. 113.
    Edwards, R. M. (1985) Am. J. Physiol. 248, F183–F189.Google Scholar
  114. 114.
    Hughes, A. D. and Sever, P. S. (1989) Br. J. Phann. 97,950–956.CrossRefGoogle Scholar
  115. 115.
    Mellander, S. and Johansson, B. (1968) Pharmacol. Rev. 20, 117–1%.116 Ross, G. (1976) Circ. Res. 39,461–465.Google Scholar
  116. 116.
    Ross, G. (1976) Circ. Res. 39,461–465.CrossRefGoogle Scholar
  117. 117.
    Pegram, B. L., Bevan, R. D., and Bevan, J. A. (1976) Circ. Res. 39, 854–860.PubMedCrossRefGoogle Scholar
  118. 118.
    Cohen, R. A., Shepherd, J. T., and Vanhoutte, P. M. (1983) Circ. Res. 52, 16–25.PubMedCrossRefGoogle Scholar
  119. 119.
    Standen, N. B., Quayle, M., Davies, N. W., Brayden, J. E., Huang, Y., and Nelson, M. T. (1989) Science 245,177–180.PubMedCrossRefGoogle Scholar
  120. 120.
    Ashcroft, F. M. (1988) Annu. Rev. Neurosci.11, 97–118.PubMedCrossRefGoogle Scholar
  121. 121.
    Nelson, M. T., Huang, Y., Brayden, J. E., Hescheler, J., and Standen, N. B. (1990) Nature 344,770–773.PubMedCrossRefGoogle Scholar
  122. 122.
    Towart, R. (1981) Circ. Res. 8,650–657.CrossRefGoogle Scholar
  123. 123.
    Cauvin, C., Saida, K., and van Breeman, C. (1984) Blood Vessels 21, 23–31.PubMedGoogle Scholar
  124. 124.
    Edvinsson, L., Fredholm, B. B., Hamel, E., Jansen, I., and Verrecchia, C. (1985) Neurosci. Lett. 58,213–217.PubMedCrossRefGoogle Scholar
  125. 125.
    Itoh, T., Sasafuri, T., Makita, Y., Kanmura, Y., and Kuriyama, H. (1985) Am. J. Physiol. 249, H231–H240.PubMedGoogle Scholar
  126. 126.
    Moskowitz, M. A. (1984) Ann. Neurol.16,157–168.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Tim O. Neild
  • Joseph E. Brayden

There are no affiliations available

Personalised recommendations