Skip to main content
SpringerLink
Log in

DU-PAN-2, A Clinically Useful Mucin Marker of Differentiation of Pancreatic and Other Ductal Cells and Their Tumors

  • Chapter
Book cover Serological Cancer Markers

Part of the book series: Contemporary Biomedicine ((CB,volume 11))

  • 120 Accesses

Abstract

There are a number of distinguishing and unique clinical and biological aspects of exocrine pancreatic cancer that make diagnosis difficult. The disease is rarely diagnosed at an early stage. This is the major factor in the poor prognosis of this malignancy. Symptoms, when they occur, are vague and include anorexia, weight loss, abdominal pain, vomiting, nausea, and jaundice. Patients with tumors of the head of the pancreas often have symptoms related to tumor invasion and compression of the common bile duct. Tumor involvement in the head of the pancreas is found in 80–90% of patients with exocrine pancreatic tumors. The remaining 10–20% of patients have tumors in the tail of the pancreas and are not likely to have early jaundice because of slight involvement of the biliary duct system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abe, M. and D. Kufe (1989), Cancer Res. 49, 2834–2839.

    PubMed  CAS  Google Scholar 

  • Barnd, D., M. Lan, R. Metzgar, and O. Finn (1989), Proc. Natl. Acad Sci. USA 86, 7159–7163.

    Article  PubMed  CAS  Google Scholar 

  • Borowitz, M., F. Tuck, W. Sindelar, P. Fernsten, and R. Metzgar (1984), J. Natl. Cancer Inst. 72, 999–1005.

    PubMed  CAS  Google Scholar 

  • Burchell, J., S. Gendler, J. Taylor-Papadimitriou, A. Girling, A. Lewis, R. Millis, and D. Lamport (1987), Cancer Res. 47, 5476–5482.

    PubMed  CAS  Google Scholar 

  • Cho, M., S. Watanabe, and T. Takeuchi (1986), J. Jpn. Panc. Soc. 1, 69 (in Japanese).

    Google Scholar 

  • Gendler, S., J. Taylor-Papadimitriou, T. Duhig, J. Rothbard, and J. Burchell (1988), J. Biol. Chem. 263,12820–12823.

    PubMed  CAS  Google Scholar 

  • Gendler, S., C. Lancaster, J. Taylor-Papadimitriou, T. Duhig, N. Peat, J. Burchell, L. Pemberton, E.M. Lelani, and D. Wilson (1990), J. Biol. Chem. 265, 15286–15293.

    PubMed  CAS  Google Scholar 

  • Gum, J., J. Byrd, J. Hicks, N. Toribara, D. Lamport, and Y. Kim (1989), J. Biol. Chem. 264,6480–6487.

    PubMed  CAS  Google Scholar 

  • Haviland, A., M. Borowitz, P. Killenberg, M. Lan, and R. Metzgar (1988), Int. J. Cancer 41, 789–793.

    Article  PubMed  CAS  Google Scholar 

  • Hilkens, J. and F. Buijs (1988), J. Biol. Chem. 263,4215–4222.

    PubMed  CAS  Google Scholar 

  • Hollingsworth, M. and R. Metzgar (1985), in Monoclonal Antibodies in Cancer, Humana, Clifton, NJ, pp. 279–307.

    Chapter  Google Scholar 

  • Hollingsworth, M., M. Lan, S. Batra, W.N. Qi, T. Mullins, and R. Metzgar (1990), Proc. Am. Assoc. Cancer Res. 31, 482–484.

    Google Scholar 

  • Ichihara, T., A. Nakao, Y. Suzuki, N. Suzuki, T. Nonami, A. Harada, H. Takagi, and H. Nagura (1987a), J. Jpn. Panc. Soc. 2,439–449 (in Japanese).

    Google Scholar 

  • Ichihara, T., A. Nakao, J. Sakamoto, Y. Suzuki, T. Nonami, A. Harada, T. Watanabe, H. Takagi, and H. Nagura (1987b), J. Jpn. Panc. Soc. 2,460–471 (in Japanese).

    Google Scholar 

  • Kern, H., U. Rausch, and J. Mollenhauer (1986), in The Exocrine Pancreas: Biology, Patho Biology and Diseases (Go, V.L., ed.), Raven, New York, pp. 637–647.

    Google Scholar 

  • Khorrami, A., M. Lan, R. Metzgar, and B. Kaufman (1989), Glycoconjugate J. 6,428 (Abstract).

    Google Scholar 

  • Kim, Y., H. Kern, T. Mullins, M. Koriwchak, and R. Metzgar (1989), Pancreas 4, 353–362.

    Article  PubMed  CAS  Google Scholar 

  • Kloppel, G. and P. Fitzgerald (1986), in The Exocrine Pancreas: Biology, Patho Biology and Diseases (Go, V.L., ed.), Raven, NY, pp. 649–674.

    Google Scholar 

  • Lan, M., M. Hollingsworth, and R. Metzgar (1990a), Cancer Res. 50, 2997–3001.

    CAS  Google Scholar 

  • Lan, M., S. Batra, W.N. Qi, R. Metzgar, and M. Hollingsworth (1990b), J. Biol. Chem. 265,15294–15299.

    CAS  Google Scholar 

  • Lan, M., O. Finn, P. Fernsten, and R. Metzgar (1985), Cancer Res. 45, 305–310.

    PubMed  CAS  Google Scholar 

  • Lan, M., A. Khorrami, B. Kaufman, and R. Metzgar (1987a), J. Biol. Chem. 262,12863–12870.

    CAS  Google Scholar 

  • Lan, M., R. Bast, M. Colnaghi, R. Knapp, D. Colcher, and R. Metzgar (1987b), Int. J. Cancer 39, 68–72.

    Article  CAS  Google Scholar 

  • Lan, M. and R. Metzgar (1989), in Human Tumor Antigens and Specific Tumor Therapy, Liss, New York, pp. 1–11.

    Google Scholar 

  • Ligtenberg, M. J., H. Vos, A. M. Gennissen, and J. Hilkens (1990), J. Biochem. 265, 5573–5578.

    CAS  Google Scholar 

  • Mahvi, D., W. Meyers, R. Bast, H. Seigler, and R. Metzgar (1985), Ann. Surgery 202, 440–445.

    Article  CAS  Google Scholar 

  • Metzgar, R., M. Lan, Y. Kim, M. Koriwchak, T. Muffins, and M. Hollingsworth (1989), in Immunity to Cancer II (Alan R. Liss, New York), pp. 53–61.

    Google Scholar 

  • Metzgar, R., N. Rodriguez, O. Finn, M. Lan, V. Daasch, P. Fernsten, W. Meyers, W. Sindelar, R. Sandler, and H. Seigler (1984), Proc. Natl. Acad. Sci. USA 81, 5242–5246.

    Article  PubMed  CAS  Google Scholar 

  • Mullins, T., H. Kern, and R. Metzgar (1991), Pancreas, in press.

    Google Scholar 

  • Nakamura, Y., M. Leppert, P. O’Connell, R. Wolff, T. Holm, M. Culver, C. Martin, E. Fujimoto, M. Hoff, E. Kumlin, and R. White (1987), Science 235,1616–1622.

    Article  PubMed  CAS  Google Scholar 

  • Satomura, Y., H. Ohta, Y. Takemori, N. Sawabu, S. Minami, T. Kitamura, M. Mai, N. Hattori, T. Akiyama, and K. Watanabe (1986), J. Clin. Exp. Med. (Igaku No Ayumi), 137,143 (in Japanese).

    Google Scholar 

  • Satomura, Y., N. Sawabu, Y. Takamori, H. Ohta, H. Watanabe, T. Okai, K. Watanabe, H. Matsuno, and F. Konishi (1991), Pancreas (in press).

    Google Scholar 

  • Shimizu, M. and K. Yamauchi (1982), J. Biochem. 91, 515–524.

    PubMed  CAS  Google Scholar 

  • Siddiqui, J., M. Abe, D. Hayes, E. Shami, E. Yumis, and D. Kufe (1988), Proc. Natl. Acad. Sci. USA 85, 2320–2323.

    Article  PubMed  CAS  Google Scholar 

  • Suzuki, Y., T. Ichihara, A. Nakao, J. Sakamoto, H. Takagi, and H. Nagura (1988), Hepatogastroenterology 35, 128.

    PubMed  CAS  Google Scholar 

  • Swallow, D., S. Gendler, B. Griffiths, A. Kearney, S. Povey, D. Sheer, R. Palmer, and J. Taylor-Papadimitriou (1987), Ann. Hum. Genet. 51, 289–294.

    Article  PubMed  CAS  Google Scholar 

  • Takami, H., T. Furuchi, Y. Ogata, and O. Abe (1986), Jpn. J. Cancer Chem. 13, 3207–3214 (in Japanese).

    CAS  Google Scholar 

  • Takasaki, H., E. Uchida, M. Tempero, D. Burnett, R. Metzgar, and P. Pour (1987), Int. J. Pancreatol. 2, 349–361.

    PubMed  CAS  Google Scholar 

  • Takasaki, H., E. Uchida, M. Tempero, D. Burnett, R. Metzgar, and P. Pour (1988), Cancer Res. 48,1435–1438.

    PubMed  CAS  Google Scholar 

  • Takemori, Y., N. Sawabu, Y. Satomura, H. Ohta, H. Watanabe, T. Okai, M. Mai, N. Hattori, T. Akiyama, and T. Hashimoto (1987), Jpn. J. Cancer Chem. 14,119–126 (in Japanese).

    CAS  Google Scholar 

  • Tempero, M., H. Takasaki, E. Uchida, Y. Takiyama, D. Colcher, R. Metzgar, and P. Pour (1989), Am. J. Surg. Pathol. 13, 89–95.

    PubMed  Google Scholar 

  • Wahab, Z., and R. Metzgar (1991), Pancreas 6, 307–317.

    Article  PubMed  CAS  Google Scholar 

  • Williams, C S, D. H. Wieschner, A. Tanaka, I. Tsarfary, I. Keydar, and S. Pian (1990), Biochem. Biophys. Res. Commun. 170, 1331–1338.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Richard S. Metzgar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Norio Sawabu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael A. Hollingsworth
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX, USA

    Stewart Sell

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Metzgar, R.S., Sawabu, N., Hollingsworth, M.A. (1992). DU-PAN-2, A Clinically Useful Mucin Marker of Differentiation of Pancreatic and Other Ductal Cells and Their Tumors. In: Sell, S. (eds) Serological Cancer Markers. Contemporary Biomedicine, vol 11. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0401-5_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-0401-5_16

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6745-4

  • Online ISBN: 978-1-4612-0401-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation