CA 15–3 Assay for the Detection of Episialin

A Serum Marker for Breast Cancer
  • John Hilkens
Part of the Contemporary Biomedicine book series (CB, volume 11)

Abstract

Monoclonal antibody (MAb) technology has facilitated the development of several new assays to determine the levels of tumor-associated antigens in serum. Such markers are commonly used for the management of disease in cancer patients. For breast cancer, several assays have been developed based on MAbs against a sialomucin called episialin. These assays appear to be useful tools for monitoring breast cancer, since they show a higher sensitivity than the commonly used CEA assay.

Keywords

Carbohydrate Adenoma Serine Oncol Sarcoma 

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References

  1. Abe, M. and D. W. Kufe (1987), J. Immunol. 139, 257–261.PubMedGoogle Scholar
  2. Ashall, F., M. E. Bramwell, and H. Harris (1982), Lancet ii, 1–6.CrossRefGoogle Scholar
  3. Bieglmayer C., T. Szepesi, and W. Neunteufel (1988), Cancer Lett. 42, 199–206.PubMedCrossRefGoogle Scholar
  4. Bieglmayer C., T. Szepesi, W. Neunteufel, and C. Nowotny (1989), Tumor Biol. 10, 232–242.CrossRefGoogle Scholar
  5. Bonfrer, J. M. G. (1986), in I Markers Tumorali in Ginecologia (Coli, A. and G. Torre, eds.), CIC Edizioni Intemazionali, Rome, pp. 271–273.Google Scholar
  6. Bramwell, M. E., V. P. Bhavanandan, G. Wiseman, and H. Harris (1983), Br. J. Cancer 48,177–183,1983.PubMedCrossRefGoogle Scholar
  7. Bray, K. R., J. E. Koda, and P. K. Gaur (1987), Cancer Res. 47, 5853–5860.PubMedGoogle Scholar
  8. Burchell, J., D. Wang, and J. Taylor-Papadimitriou (1984), Int. J. Cancer 34, 763–768.PubMedCrossRefGoogle Scholar
  9. Burchell, J., S. Gendler, J. Taylor-Papadimitriou, A. Girling, A. Lewis, R. Millis, and D. Lamport (1987), Cancer Res. 47, 5476–5482.PubMedGoogle Scholar
  10. Burchell, J., J. Taylor-Papadimitriou, M. Boshell, S. Gendler, and T. Duhig (1989), Int. J. Cancer 44, 691–696.PubMedCrossRefGoogle Scholar
  11. Ceriani, R. L., J. A. Peterson, J. Y. Lee, R. Moncada, and E. W. Blank (1983), Somatic Cell Genet. 9, 415–427.PubMedCrossRefGoogle Scholar
  12. Ceriani, R. L. and E. W. Blank (1988), Cancer Res. 48, 4664–4672.PubMedGoogle Scholar
  13. Colomer, R., A. Ruibal, and L. Salvador (1989a), Cancer 64,1674–1681.CrossRefGoogle Scholar
  14. Colomer, R., A. Ruibal, J. Genolla, and L. Salvador (1989b), Br. J. Cancer 59,283–286.CrossRefGoogle Scholar
  15. Colomer, R., A. Ruibal, J. Genolla, D. Rubio, J. M. Del Campo, R. Bodi, and L. Salvador (1989c), Breast Cancer Res. Treat. 13,123–133.CrossRefGoogle Scholar
  16. Cordell, J., T. C. Richardson, K. A. F. Pulford, A. K. Gosh, K. C. Gatter, E. Heyderman, and D. Y. Mason (1985), Br. J. Cancer 52, 347–354.PubMedCrossRefGoogle Scholar
  17. DeKretser, T. A.., H. J. Thorne, D.J., Jacobs, and D.G. Jose (1985), Eur. J.Cancer Clin. Oncol. 21,1019–1035.CrossRefGoogle Scholar
  18. DeKretser, T. A., H. J. Thorne, D. Picone, and D. G. Jose (1986), Int. J. Cancer 37, 705–712.CrossRefGoogle Scholar
  19. Ellis, I. O., R. A. Robins, C. W. Elston, R. W. Blarney, B. Ferry, and R. W. Baldwin (1984), Histopathology 8, 501–516.PubMedCrossRefGoogle Scholar
  20. Epenetos A. A., Britton, K. E., Mather, S., Shepherd, J., Granowska, M., Taylor-Papadimitriou, J., Nimmon, C.C., Durbin, H., Hawkins, L. R., Malpas, J. S. and Bodmer, W. F. (1982a), Lancet ii,, 999–1004.CrossRefGoogle Scholar
  21. Epenetos, A. A., G. Canti, J. Taylor-Papadimitriou, M. Curling, and W. F. Bodmer (1982b), Lancet ii, 1004–1006.CrossRefGoogle Scholar
  22. Epenetos, A. A., N. Courtinay Luck, K. E. Hainan, and G. Hooker (1984), Lancet ii, 1441–1443.Google Scholar
  23. Gendler, S.J., J. Taylor-Papadimitriou, T. Duhig, J. Rothbard, and J. M. Burchell (1988), J. Biol. Chem. 263,12820–12823.PubMedGoogle Scholar
  24. Gendler, S. J., E. P. Cohen, A. Craston, T. Duhig, G. Johnstone, and D. Barnes (1990), Int. J. Cancer. 45, 431–435.PubMedCrossRefGoogle Scholar
  25. Hageman, Ph., J. L. Peterse, J. Hilkens, and J. Hilgers (1987), in Application of Monoclonal Antibodies in Tumor Pathology ( Ruiter, D., S. Warnaar, and G. Fleuren, eds.), Martinus Nijhoff, Dordrecht, The Netherlands, pp. 167–190.CrossRefGoogle Scholar
  26. Hayes, D. F., V. R. Zurawski, and D. W. Kufe (1986), J. Clin. Oncol. 4, 1542–1550.PubMedGoogle Scholar
  27. Hayes, D. F., D. T. Kiang, A. H. Korzun, C. Tondini, W. C. Wood, and D. W. Kufe (1988a), Proceedings of ASCO 7, 38.Google Scholar
  28. Hayes, D. F., H. Sekine, D. Markus, C. A. Alper, and D. W. Kufe (1988b), Blood 71, 436–440.Google Scholar
  29. Hayes, D. F., H. Sekine, T. Ohno, M. Abe, K. Keefe, and D. W. Kufe (1985), J. Clin. Invest. 75,1671–1678.PubMedCrossRefGoogle Scholar
  30. Heyderman, E., I. Strudley, G. Powell, T. C. Richardson, D. L. Cordell, and D. Y. Mason (1985), Br. J. Cancer 52, 355–361.PubMedCrossRefGoogle Scholar
  31. Hilkens, J. and F. Buys (1988), J. Biol. Chem. 263, 4215–4222.PubMedGoogle Scholar
  32. Hilkens, J., F. Buys, and M. Ligtenberg (1989), Cancer Res. 49, 786–793.PubMedGoogle Scholar
  33. Hilkens, J., V. Kroezen, H. Bonfrer, M. De Jong-Bakker, and P. F. Bruning (1986), Cancer Res. 46, 2582–2587.PubMedGoogle Scholar
  34. Hilkens, J., F. Buys, J. Hilgers, Ph. Hageman, J. Calafat, A. Sonnenberg, and M. Van der Valk (1984a), Int. J. Cancer 34,197–206.CrossRefGoogle Scholar
  35. Hilkens, J., V. Kroezen, H. Bonfrer, P. F. Bruning, J. Hilgers, and M. Van Eijkeren (1984b), in Protides of the Biological Fluids, vol. 31 (Peeterse, H., ed.), Pergamon, Oxford, pp. 651–653.Google Scholar
  36. Hilkens, J., J. M. G. Bonfrer, V. Kroezen, M. Van Eijkeren, W. Nooyen, M. De Jong-Bakker, and P. F. Bruning (1987), Int. J. Cancer 39, 431–435.PubMedCrossRefGoogle Scholar
  37. Hull S. R., and K. Carraway (1988), J. Cell Biochem. [Suppl.] 12E, 130.Google Scholar
  38. Kallioniemi, O. P., H. Oksa, R. K. Aaran, T. Hietanen, M. Lehtinen, and T. Koivula (1988), Br. J. Cancer, 58 213–215.PubMedCrossRefGoogle Scholar
  39. Kerin, M. J., O. J. McAnena, V. P. O’Malley, H. Grimes, and H. F. Given (1989), Br. J. Surg., 76, 838–839.PubMedCrossRefGoogle Scholar
  40. Koldowski, U., U. Wargalla, J. Hilkens, B. Feldhammer, S. Kroizin, M. Bross, and J. Hilgers (1986), Tumor Diagnostik und Therapie 7,125–128.Google Scholar
  41. Kufe, D., G. Inghiriami, M. Abe, D. Hayes, H. Justi-Wheeler, and J. Schlom (1984), Hybridoma 3, 223–232.PubMedCrossRefGoogle Scholar
  42. Lan, M. S., R. C. Bast, M. I. Colnaghi, R. C. Knapp, D. Colcher, J. Schlom, and R. S. Metzgar (1987), Int. J. Cancer 39, 68–71.PubMedCrossRefGoogle Scholar
  43. Lashford, L. S., A. G. Davies, R. B. Richardson, S. P. Boume, J. A. Bullimore, H. Eckert, J. T. Kemshead, and H. B. Coakham (1988), Cancer 61, 857–868.PubMedCrossRefGoogle Scholar
  44. Ligtenberg, M. J. L., H. L. Vos, A. M. C. Gennissen, and J. Hilkens (1990), J. Biol. Chem. 265, 5573–5578.PubMedGoogle Scholar
  45. Linsley, P. S., J. P. Brown, J. L. Magnani, and D. Horn (1988a), Cancer Res. 48, 2138–2148.Google Scholar
  46. Linsley, P. S, J. C. Kallestadt, and D. Horn (1988b), J. Biol. Chem. 263, 8390–8397.Google Scholar
  47. Litvinor, S. L., P. Hageman, M. J. I. Ligtenberg, and J. Hilkens, submitted for publication.Google Scholar
  48. Merlo, G. R., J. Siddiqui, C. S. Cropp, D. S. Liscia, R. Lidereau, R. Callahan, and D. W. Kufe (1989), Cancer Res. 49, 6966–6971.PubMedGoogle Scholar
  49. Metzgar, R. S., N. Rodriquez, O. J. Finn, M. S. Lan, V. N. Daasch, P. Fernsten, W. C. Meyers, W. F. Sindelar, R. S. Sandler, and H. F. Seigler (1984), Proc. Natl. Acad. Sci. USA 81, 5242–5246.PubMedCrossRefGoogle Scholar
  50. Molthoff, C. F. M., H. M. M. Schlüper, H. M. Pinedo, and E. Boyen, submitted for publication.Google Scholar
  51. Omar, Y. T., A. E. Behbehani, N. Al-Naqeeb, M. M. Motawy, M. O. Foudeh, A. H. Awwad, M. Y. Nasralla, and J. J. Szymendera (1989), Int. J. Biol. Markers 4, 81–86.PubMedGoogle Scholar
  52. Papsidero, L. D. and E. A. Johnson (1986), Int. J. Cancer 37, 697–701.PubMedCrossRefGoogle Scholar
  53. Papsidero, L. D., G. A. Croghan, M. J. O’Connell, L. A. Valenzuela, T. Nemoto, and T. M. Chu (1983), Cancer Res. 43,1741–1747.PubMedGoogle Scholar
  54. Pons-Anicet, D. M.F., B.P. Krebs, R. Mira, and M. J. Namer (1987), Br. J. Cancer 55, 567–569.PubMedCrossRefGoogle Scholar
  55. Pons-Anicet, D. M. F., A. Ramaldi, B. P. Krebs, and M. J. Namer (1988), Tumor Marker Oncol. 3, 2.Google Scholar
  56. Price, M. R., S. Edwards, R. A. Robins, J. Hilgers, J. Hilkens, and R. W. Baldwin (1986), Eur. J. Cancer Clin. Oncol. 22,115–117.PubMedCrossRefGoogle Scholar
  57. Price, M. R., G. Cocker, S. Edwards, I. S. Nagra, R. A. Robins, M. Williams, R. W. Blarney, D. M. Swallow, and R. W. Baldwin (1987), Eur. J. Cancer Clin. Oncol. 23,1169–1176.PubMedCrossRefGoogle Scholar
  58. Scambia, G., P. Benedetti, G. Panici, L. Baiocchi, S. Perrone., S. Greggi, and S. Mancuso (1988), Gynecol. Oncol. 30, 265–273.PubMedCrossRefGoogle Scholar
  59. Schmidt-Rhode, P., K. D. Schulz, G. Sturm, A. Raab-Frick, and H. Prinz (1987), Int. J. Biol. Markers., 2,135–142.PubMedGoogle Scholar
  60. Shimizu, M. and K. Yamauchi (1982), J. Biochem. 91,1741–1747.Google Scholar
  61. Stacker, S. A., C. H. Thompson, C. Riglar, and I. F. C. McKenzie (1985), J. Natl. Cancer Inst. 75, 801–811.PubMedGoogle Scholar
  62. Stacker, S. A., C. H. Thompson, N. P. Sacks, J. Tjandra, M. G. Lowe, J Bishop, and I. F. C. McKenzie (1988), Cancer Res. 48, 7060–7066.PubMedGoogle Scholar
  63. Stewart, J. S. W., V. Hird, D. Snook, M. Sullivan, G. Hooker, N. Courtenay-Luck, G. Sivolapenko, M. Griffith, M. J. Myers, H. M. Lambert, A. J. Munro, and A. A. Apenetos (1989), Int. J. Radiat. Oncol. Biot. Phys. 16, 405–413.CrossRefGoogle Scholar
  64. Swallow, D. M., S. Gendler, B. Griffiths, G. Corny, J. Taylor-Papadimitriou, and M. E. Bramwell (1987), Nature 328, 82–84.PubMedCrossRefGoogle Scholar
  65. Swets, J. A. (1988), Science 240,1285–1292.PubMedCrossRefGoogle Scholar
  66. Taylor-Papadimitriou, J., J. A. Peterson, J. Arklie, J. Burchell, R. L. Ceriani, and W. F. Bodmer (1981), Int. J. Cancer 28, 17–21.PubMedCrossRefGoogle Scholar
  67. Thompson, C. H., S.L. Jones, R. H. Whitehead, and I. F. C. McKenzie (1983), J. Natl. Cancer Inst. 70, 409–419.PubMedGoogle Scholar
  68. Tjandra, J. J., I. S. Rusell, J. P. Collins, J. T. Andrew, M. Lichtenstein, D. Binns, and I. F. C. McKenzie (1989), Cancer Res. 49,1600–1608.PubMedGoogle Scholar
  69. Tobias, R., C. Rothwell, J. Wagner, A. Green, and Y. S. Liu (1985), Clin., Chem. 31, 986.Google Scholar
  70. Tondini, C., D. F. Hayes, R. Gelman, I. C. Henderson, and D. W. Kufe (1988), Cancer Res. 48, 4107–4112.PubMedGoogle Scholar
  71. Touitou, Y., A. Darbois, A. Bogdan, A. Auzeby, and S. Keusseoglou (1989), Br. J. Cancer 60, 419–420.PubMedCrossRefGoogle Scholar
  72. Van Dalen, A. (1989), Ann. Chir. Gynaecol. 78, 54–64.PubMedGoogle Scholar
  73. Van Dalen, A., J. M. G. Bonfrer, H. W. Dupree, J. Heering, D. L. van der Linde, and W. J. Nooijen (1986), in Clinical Relevance of New Monoclonal Antibodies (Greten, H. and R. Klapdor, eds.), Georg Thieme, Verlag, Stuttgart, p. 185.Google Scholar
  74. Wreschner, D. H., M. Hareuveni, I. Tsarfaty, N. Smorodinsky, J. Horev, J. Zaretsky, P. Kotkes, M. Weiss, R. Lathe, A. Dion, and I. Keydar (1990), Eur. J. Biochem. 189, 463–473.PubMedCrossRefGoogle Scholar
  75. Xing, P. X., J. J. Tjandra, K. Reynold, P. J. McLaughlin, D. F. J. Purcell, and I. F. C. McKenzie (1989), J. Immunol. 142, 3503–3509.PubMedGoogle Scholar
  76. Zotter, S., A. Lossnitzer, Ph. Hageman, J. F. M. Delemarre, J. Hilkens, and J. Hilgers (1987), Lab. Invest. 57,193–199.PubMedGoogle Scholar

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© Springer Science+Business Media New York 1992

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  • John Hilkens

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