Maternal Immune Responses Affecting Pregnancy and the Fetus

  • Henry N. Claman


In thinking about the immunology of human pregnancy, it is of considerable interest to consider a variety of immunological changes, situations, and disorders in which the immune system of the mother affects the fetus. These situations are quite different from the question of materno-fetal allorecognition. They present us with insights into the pathogenesis of various conditions because of the unique nature of materno-fetal interactions. This chapter will include immune syndromes peculiar to pregnancy, such as hemolytic disease of the newborn (HDN) and related isoimmune syndromes, the effect of autoimmune diseases on pregnancy and on the fetus, as well as the effect of pregnancy on the autoimmune processes. It will touch on some miscellaneous topics, such as graft-vs-host disease and pre-eclampsia, which is considered by some to have an immune pathogenesis.


Systemic Lupus Erythematosus Ankylose Spondylitis Systemic Lupus Erythematosus Patient Severe Combine Immunodeficiency Congenital Heart Block 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Henry N. Claman
    • 1
  1. 1.University of Colorado Health Sciences CenterDenver

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