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Production of Threshold Levels of Conscious Sensation by Electrical Stimulation of Human Somatosensory Cortex

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Neurophysiology of Consciousness

Part of the book series: Contemporary Neuroscientists ((CN))

Abstract

THE PRESENT WORK is part of a more general investigation into neuro-physiological activities of the cerebral cortex which may be involved in the elaboration or mediation of conscious sensation. The primary concern in these studies is the dynamics of the processes involved, rather than their topographical representation.

This study was supported successively by the Air Force Office of Scientific Research, Contract AF 18(603)-48, Office of Naval Research Contract Nonr-2968(01), and Public Health Service Grant NB-01963; and by the Harry Freund Memorial Foundation.

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References

  1. Alberts, W. W. A stimulus pulse polarity reversal unit. Electronceph. clin. Neuro-physiol., 1958, 10:172–173.

    Article  CAS  Google Scholar 

  2. Alberts, W. W., Wright, E. W., jr., Levin, G., Feinstein, B., AND Mueller, M. Threshold stimulation of the lateral thalamus and globus pallidus in the waking human. Electronceph. clin. Neurophysiol., 1961, 13:68–74.

    Article  CAS  Google Scholar 

  3. Bates, J. A. V. Observations on the excitable cortex in man. Lectures Sci. Basis Med., 1955-56, 5:333–347.

    Google Scholar 

  4. Brazier, M. A. B. The Electrical Activity of the Nervous System (2nd ed.). New York, Macmillan, 1960, pp. 178–179.

    Google Scholar 

  5. Bremer, F. Neurophysiological mechanisms in cerebral arousal. In: The Nature of Sleep. Ciba Foundation Symposium, edited by G. E. W. Wolstenholme and M. O’Connor. London, Churchill, 1961, pp. 30–50.

    Google Scholar 

  6. Brown, T. G. Studies in the physiology of the nervous system. XXII: On the phenomena of facilitation. 1. Its occurrence in reactions induced by stimulation of the “ motor„cortex of the cerebrum in monkeys. Quart. J. exp. Physiol., 1915, 9: 81–99.

    Google Scholar 

  7. Brown, T. G. Studies in the physiology of the nervous system. XXVII: On the phenomena of facilitation. 6. The motor activation of parts of the cerebral cortex other than those included in the so-called “ motor„areas in monkeys; with a note on the theory of cortical localization of function. Quart. J. exp. Physiol., 1916, 10: 103–143.

    Google Scholar 

  8. Collins, W. F., Nulsen, F. E., AND Randt, C. T. Relation of peripheral nerve fiber size and sensation in man. Arch. Neurol., 1960, 3: 381–385.

    Article  PubMed  Google Scholar 

  9. Eccles, J. C. The Physiology of Synapses. Berlin, Springer, 1964, pp. 83–86.

    Book  Google Scholar 

  10. Eijkman, E. AND Vendrik, A. J. H. Detection theory applied to the absolute sensitivity of sensory systems. Biophys. J., 1963, 3:65–78.

    Article  PubMed  CAS  Google Scholar 

  11. Ervin, F. R. AND Mark, V. H. Sterotactic thalamotomy in the human. Part II, Physiologic observations on the human thalamus. Arch. Neurol., 1960, 3: 368–380.

    Article  PubMed  CAS  Google Scholar 

  12. Evarts, E. V. Photically evoked responses in visual cortex units during sleep and waking. J. Neurophysiol., 1963, 26: 228–248.

    Google Scholar 

  13. Feinstein, B., Alberts, W. W., Wright, E. W., JR., AND Levin, G. A stereotaxic technique in man allowing multiple spatial and temporal approaches to intracranial targets. J. Neurosurg., 1960, 17: 708–720.

    Article  PubMed  CAS  Google Scholar 

  14. Foerster, O. The motor cortex in man in the light of Hughlings Jackson’s doctrines. Brain, 1936, 59:135–159.

    Article  Google Scholar 

  15. Foerster, O. Motorische Felder und Bahnen. In: Handbuch der Neurologie, edited by O. Bumke and O. Foerster. Berlin, Springer, 1936, vol. 6, pp. 1–357.

    Google Scholar 

  16. Foerster, O. Sensible corticale felder. In: Handbuch der Neurologie, edited by O. Bumke and O. Foerster. Berlin, Springer, 1936, vol. 6., pp. 358–448.

    Google Scholar 

  17. Freeman, W. F. Alterations in prepyriform evoked potential in relation to stimulus intensity. Exp. Neurol., 1962, 6: 70–84.

    Article  PubMed  CAS  Google Scholar 

  18. Galambos, R., AND Sheatz, G. C. Evoked cortical auditory responses. Fed. Proc., 1959, 18:49.

    Google Scholar 

  19. Galambos, R., Sheatz, G., AND Vernier, V. G. Electrophysiological correlates of a conditioned response in cats. Science, 1956, 123: 376–377.

    Article  PubMed  CAS  Google Scholar 

  20. Gerard, R. W. The biological roots of psychiatry. Amer. J. Psychiat., 1955, 112: 81–90.

    PubMed  CAS  Google Scholar 

  21. Hensel, H. AND Boman, K. K. A. Afferent impulses in cutaneous sensory nerves in human subjects. J. Neurophysiol., 1960, 23: 564–578.

    PubMed  CAS  Google Scholar 

  22. Hern, J. E. C, Landgren, S., AND Phillips, C. G. Selective excitation of corticofugal neurons by surface-anodal stimulation of the baboon’s motor cortex. J. Physiol., 1962, 161:73–90.

    PubMed  CAS  Google Scholar 

  23. Hern, J. E. C, Phillips, C. G., AND Porter, R. Electrical thresholds of unimpaled corticospinal cells in the cat. Quart. J. exp. Physiol., 1962, 47:134–140.

    PubMed  CAS  Google Scholar 

  24. Landgren, S., Phillips, C. G., AND Porter, R. Minimal synaptic actions of pyramidal impulses on some alpha motoneurones of the baboon’s hand and forearm. J.Physiol., 1962, 161: 91–111.

    PubMed  CAS  Google Scholar 

  25. Lansing, R. W., Schwartz, E., AND Lindsley, D. B. Reaction time and EEG activation under alerted and non-alerted conditions, J. exp. Psychol., 1959, 58:1–6.

    Article  PubMed  CAS  Google Scholar 

  26. Levin, G., Feinstein, B., Kreul, E. J., Alberts, W. W., AND Wright, E. W., JR. Stereotaxic surgery for parkinsonism. J. Neurosurg., 1961, 18: 210–216.

    Article  PubMed  CAS  Google Scholar 

  27. Libet, B., Alberts, W. W., Wright, E. W., jr., Levin, G., AND Feinstein, B. Sensory perception by direct stimulation of human cerebral cortex: stimulus parameters. Fed. Proc., 1959, 18: 92.

    Google Scholar 

  28. Libet, B., Alberts, W. W., Wright, E. W., jr., Levin, G., AND Feinstein, B. Direct excitation of human somatosensory cortex. Electroenceph. clin. Neurophysiol., 1961, 13:498.

    Google Scholar 

  29. Lilly, J. C. Correlations between neurophysiological activity in the cortex and shortterm behavior in the monkey. In: Biological and Biochemical Bases of Behavior, edited by H. F. Harlow and E. N. Woolsey, Madison, Univ. of Wisconsin Press, 1958, pp. 83–100.

    Google Scholar 

  30. Lilly, J. C. Injury and excitation by electric currents. A. The balanced pulse-pair waveform. In: Electrical Stimulation of the Brain, edited by D. E. Sheer. Austin, Univ. of Texas Press, 1961, pp. 60–64.

    Google Scholar 

  31. Lilly, J. C, Austin, G. M., AND Chambers, W. Threshold movements produced by excitation of cerebral cortex and efferent fibers with some parametric regions of rectangular current pulses (cats and monkeys). J. Neurophysiol., 1952, 15: 319–341.

    PubMed  CAS  Google Scholar 

  32. Macintyre, W. F., Bidder, T. G., AND Rowland, V. The production of brain lesions with electric currents. Proc. Nat. Biophys. Conf., 1st, 1957, (Pub. 1959) pp. 723–732.

    Google Scholar 

  33. Mihailovc, L. AND Delgado, J. M. R. Electrical stimulation of monkey brain with various frequencies and pulse durations. J. Neurophysiol., 1956, 19: 21–36.

    Google Scholar 

  34. Penfield, W. AND Boldrey, E. Somatic motor and sensory representation in the ncerebral cortex of man as studied by electrical stimulation. Brain, 1937, 60: 389–443.

    Article  Google Scholar 

  35. Penfield, W. AND Jasper, H. Epilepsy and the Functional Anatomy of the Human Brain. Boston, Little, Brown, 1954, pp. 41–106.

    Google Scholar 

  36. Penfield, W. AND Rasmussen, T. The Cerebral Cortex of Man. New York, Macmillan, 1952, pp. 47, 102-105,185-196.

    Google Scholar 

  37. Phillips, C. G. AND Porter, R. Unifocal and bifocal stimulation of the motor cortex. J. Physiol., 1962, 162: 532–538.

    PubMed  CAS  Google Scholar 

  38. Sigel, H. Prick threshold stimulation with square-wave current; a new measure of skin sensibility. Yale J. Biol. Med., 1953, 26:145–154.

    PubMed  CAS  Google Scholar 

  39. Ward, H. P. Stimulus factors in septal self-stimulation. Amer. J. Physiol., 1959, 196:779–782.

    PubMed  CAS  Google Scholar 

  40. Zanchetti, A. AND Brookhart, J. M. Cortico-spinal responsiveness during EEG arousal in the cat. Amer. J. Physiol., 1958, 195: 262–266.

    PubMed  CAS  Google Scholar 

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Libet, B., Alberts, W.W., Wright, E.W., Delattre, L.D., Levin, G., Feinstein, B. (1993). Production of Threshold Levels of Conscious Sensation by Electrical Stimulation of Human Somatosensory Cortex. In: Neurophysiology of Consciousness. Contemporary Neuroscientists. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0355-1_1

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  • DOI: https://doi.org/10.1007/978-1-4612-0355-1_1

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-6722-5

  • Online ISBN: 978-1-4612-0355-1

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