Species Differences in Pial Functional Characteristics

  • Noboru Toda
Part of the Vascular Biomedicine book series (VB)


Endogenous vasoactive mediators and autonomic efferent nerves regulate vascular resistance and blood flow in the brain as a whole or in various regions, and participate in the pathogenesis of cerebral circulatory disturbances. There are variations in the response of cerebral arteries from primate and subprimate mammals, and the data obtained from subprimate arteries cannot always be applied to humans. Therefore, information as to similarities and differences in their response is quite important in evaluating the physiological role and involvement in the pathogenesis of the mediators and nerves in healthy individuals and patients. From the experimental data obtained to date, vasoactive mediators can be classified into three groups:
  1. 1

    Mediators that produce opposite responses in primate and subprimate cerebral arteries, such as dopamine and histamine

  2. 2

    Those that produce quantitatively different magnitudes of response, such as norepinephrine, angiotensin II, and prostaglandin (PG) Fla

  3. 3

    Those that produce similar responses, including serotonin, isoproterenol, and nicotine



Nitric Oxide Cerebral Artery Atrial Natriuretic Peptide Japanese Monkey Middle Cerebral Arteries3 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1994

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  • Noboru Toda

There are no affiliations available

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