Comparative Distribution of Receptor Types in the Mammalian Brain

  • Than-Vinh Dam
  • Rémi Quirion
Part of the The Receptors book series (REC)


The tachykinins (or neurokinins [NK]) are a group of structurally related peptides found in many regions of central nervous system, as well as in various peripheral tissues (Erspamer, 1981; Pernow, 1983; Maggio, 1988). Mammalian NKs are derived from the preprotachykinin I and II genes (PPT-I and PPT-II), two different but related genes (Nakanishi, 1987; Krause et al., 1989). Substance P (SP), neurokinin A (NKA), and the NKA-derived peptides, neuropeptide K, neuropeptide γ(NPγ), and NKA (3–10) are encoded by mRNAs resulting from PPT-I gene transcription, whereas neurokinin B (NKB) is derived from the maturation of the PPT-II gene (Nakanishi, 1987; Krause et al., 1989). These various NKs produce their physiological effects by activating specific membrane receptors.


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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Than-Vinh Dam
  • Rémi Quirion

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