History of Tachykinin Receptors
The rapid advances in molecular pharmacology in recent years have made the concept of multiple receptors and receptor subtypes for neurotransmitters and neuropeptides a commonplace. We are no longer surprised to learn that on closer examination the muscarinic receptor exists in five distinct molecular forms, encoded by separate genes (Hulme et al., 1990), or that the dopamine receptor similarly has five subtypes, some of which in turn exist in a variety of isoforms because of variable mRNA splicing (Iversen, 1992), or the existence of genetically determined minor variants (Van Tol et al., 1992). That the varied biological actions of the three mammalian tachykinins should be mediated by three different receptors is thus easily accepted—indeed, one would anticipate that such a complex family of related neuropeptides might be associated with a larger number of receptor subtypes.
KeywordsSelective Agonist Kinin Receptor Tachykinin Receptor Varied Biological Action Nonpeptide Antagonist
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