Pharmacological Characterization of Receptor Types

  • Domenico Regoli
  • Noureddine Rouissi
  • Pedro D’Orléans-Juste
Part of the The Receptors book series (REC)


The various biological actions of substance P and related tachykinins/neurokinins are mediated by three different receptor types, which were named NK1, NK2 and NK3 during the Montreal Symposium in 1986 (Henry, 1987). The three receptors have been characterized pharmacologically (Regoli et al., 1987a, Regoli et al., 1988, Regoli et al., 1989), biochemically (Lavielle et al., 1988; Buck et al., 1991), and genetically (Nakanishi, 1991). In vivo activities have been attributed to each receptor by Maggi et al. (1987), Regoli et al. (1988), and Maggi et al. (1993). Cloning and sequencing of receptors and the study of receptor properties of mRNA expressed in special systems (Nakanishi, 1991) appear to validate the three physiological entities.


Selective Agonist Plasma Extravasation Neurokinin Receptor Tachykinin Receptor Rabbit Pulmonary Artery 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Domenico Regoli
  • Noureddine Rouissi
  • Pedro D’Orléans-Juste

There are no affiliations available

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