History of Tachykinin Peptides

  • John E. Maggio
  • Patrick W. Mantyh
Part of the The Receptors book series (REC)


A scientific highlight of the first half of the twentieth century was the discovery and characterization of many biologically active molecules. Many large (hormones, neuropeptides) and small (classical transmitters) intercellular messengers were described during this period. Among these was substance P, which claims the longest scientific history and is arguably the most thoroughly characterized of the brain—gut peptides. It is the oldest neuropeptide in the sense that it was the first active compound from neural tissue that was later shown to be a peptide. For 50 years after its discovery, substance P (SP) was generally believed to be the only tachykinin in mammals. The relatively recent discovery of other mammalian tachykinins has raised many important new questions about the physiological role of this peptide family and has reawakened interest in the field.


Tachykinin Receptor Amphibian Skin Rabbit Jejunum Mammalian Spinal Cord Tachykinin Peptide 
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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • John E. Maggio
  • Patrick W. Mantyh

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