Abstract
The clinical features most suggestive of asthma are recurrent episodes of wheezing, cough, and dyspnea. Wheezing is caused by the partial obstruction (narrowing) of one or more airways in association with airflow of sufficient velocity to generate the wheeze (1,2). Although wheezing is the most characteristic clinical manifestation of asthma, it is not always detectable in the asthmatic patient. It is often absent when the asthmatic process is in remission, and it is occasionally absent in the most severe attacks, presumably because the patient is unable to generate sufficient airflow velocity to produce the wheeze. Conversely, wheezing may be a prominent manifestation of a number of non-asthmatic forms of diffuse or localized airway obstruction. It is clear that asthma cannot be diagnosed solely upon the presence of wheezing, and it cannot be ruled out by the absence of wheezing.
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References
Forgacs P. Lung Sounds. Balliere Tindall, London, 1978.
Hollingsworth HM. Wheezing and stridor. Clin. Chest Med. 1987; 8:231–240.
Gross NH. What is this thing called love—or, defining asthma. Am. Rev. Resp. Dis. 1980; 121:203–204.
American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am. Rev. Resp. Dis. 1987; 136:225–243.
Pratter WR, Hingston DM, and Irwin RS. Diagnosis of bronchial asthma by clinical evaluation: an unreliable method. Chest 1983; 84:42–47.
Kang BC, Grizz V, and Phillips B. Nonwheezing bronchial asthma diagnosed by methacholine challenge. Am. J. Med. 1990; 88:675–677.
MacDonnell KF and Chawla SS. Differential diagnosis of asthma, in Bronchial Asthma: Mechanisms and Therapeutics, 2nd ed. (Weiss EB, Segal MS, and Stein M, eds.), Little, Brown and Co., Boston, MA, 1985; pp. 323–352.
Amin NM. Unusual causes of wheezing in adults. Immunol. Allergy Pract. 1986; 8:154–156.
Holden DA and Mehta AC. Evaluation of wheezing in the nonasthmatic patient. Cleve. Clin. J. Med. 1990; 57:345–352.
Reed CE and Li JTC. Nocturnal asthma: approach to the patient. Am. J. Med. 1988; 85(Suppl. 1B):14–16.
Li JTC and O’Connell EJ. Viral infections and asthma. Ann. Allergy 1987; 59:321–328.
Busse WW. The contribution of viral respiratory infections to the pathogenesis of airway hyperreactivity. Chest 1988; 93:1076–1082.
Hudgel DW, Langston L, Seiner JC, and McIntosh K. Viral and bacterial infections in adults with chronic asthma. Am. Rev. Resp. Dis. 1979; 120:393–397.
Hahn DL, Dodge RW, and Golubjatnikov R. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA 1991; 266:225–230.
King TE Jr. Bronchiolitis obliterans. Lung 1989; 167:69–93.
Dauber JH and Zeevi A. Pulmonary complications of lung transplantation, in Immunologically Mediated Pulmonary Diseases (Lynch JP III and DeRemee RA, eds.), JB Lippincott, Philadelphia, PA, 1992; 169–188.
Griffith DE and Garcia JGE. Asthmatic bronchitis. Semin. Resp. Infection 1988; 3:27–39.
Rachelefsky GS, Osher A, Dooley R, Ank B, and Stiem ER. Coexistent respiratory allergy and cystic fibrosis. Am. J. Dis. Child. 1974; 122:355–358.
Van Asperen PP, Manglick PM, and Allen H. Mechanisms of bronchial hyper-reactivity in cystic fibrosis. Pediatr. Pulmonol. 1988; 5:139–144.
Marini JJ, Pearson DJ, Hudson LD, and Lakshminarayan S. The significance of wheezing in chronic airflow obstruction. Am. Rev. Resp. Dis. 1979; 120: 1069–1072.
Lillington GA and Müller NL. Radiological imaging in the detection and differentiation of diffuse obstructive airway diseases. Clin. Rev. Allergy 1990; 277–290.
Gamsu G, Borson DB, Webb WR, and Cunningham JH. Structure and function in tracheal stenosis. Am. Rev. Resp. Dis. 1980; 121:519–531.
Acres JC and Kryger MH. Clinical significance of pulmonary function tests: upper airway obstruction. Chest 1981; 80:207–211.
Cardiac Asthma. Lancet 1990; 335:693–694.
Fishman AP. Cardiac asthma—a fresh look at an old wheeze. N. Engl. J. Med. 1989; 320:1346–1348.
Cabanes LR, Weber SN, Matran R, Regnard J, Mo R, Degeorges MF, and Lockhart A. Bronchial hyperresponsiveness to methacholine in patients with impaired left ventricular function. N. Engl. J. Med. 1989; 320:1317–1322.
Moser KM. State of the art: Pulmonary embolism. Am. Rev. Resp. Dis. 1977; 115:829–852.
Windebank W, Boyd G, and Moran F. Pulmonary thromboembolism presenting as asthma. Br. Med. J. 1973; 1:90–94.
Lillington GA, Ruhl RA, Peirce TH, and Gorin AB. Removal of endobronchial foreign body by fiberoptic bronchoscopy. Am. Rev. Resp. Dis. 1976; 113:387–390.
Landay MJ, Christensen EE, and Bynum LJ. Pulmonary manifestations of acute aspiration of gastric contents. Am. J. Roentgenol. 1978; 131:587–562.
Mansfield LE. Gastroesophageal reflux and respiratory disorders: a review. Ann. Allergy 1989; 62:158–163.
Reflux and respiratory symptoms. Lancet 1990; 336:282–283.
Sontag SJ. Gut feelings about asthma: the burp and the wheeze. Chest 1991; 99:1321–1323.
Cello JP. Eosinophilic gastroenteritis—a complex disease entity. Am. J. Med. 1979; 67:1097–1104.
Maton PN. The carcinoid syndrome. JAMA 1988; 260:1602–1605.
Malo JN and Pepys J. Extrinsic allergic bronchioloalveolitis and allergic bronchopulmonary aspergillosis, in Bronchial Asthma: Mechanisms and Therapeutics, 2nd ed. (Weiss EB, Segal MS, and Stein M, eds.), Little, Brown and Co., Boston, MA, 1985; pp. 528–542.
Lillington GA. Pulmonary infiltration with eosinophilia, in A Diagnostic Approach to Chest Diseases, 3rd ed. Williams and Wilkins, Baltimore, MD, 1987; pp. 477–486.
Carrington CB, Addington WW, Goff AM, Madoff IM, Marks A, Schwaber JR, and Gaensler EA. Chronic eosinophilic pneumonia. N. Engl. J. Med. 1969; 280:787–798.
Lanham JG, Elkon KB, Pusey CD, and Hughes GR. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. Medicine 1984; 63:65–81.
Goldman J and Muers M. Vocal cord dysfunction and wheezing. Thorax 1991; 46:401–404.
Downing ET, Braman SS, Fox MJ, and Currao WM. Factitious asthma. JAMA 1982; 248:2878–2882.
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© 1994 Springer Science+Business Media New York
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Lillington, G.A., Lin, Hw. (1994). Differential Diagnosis of Asthma in Adults Asthma, Occult Asthma, and Pseudoasthma. In: Gershwin, M.E., Halpern, G.M. (eds) Bronchial Asthma. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0297-4_8
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DOI: https://doi.org/10.1007/978-1-4612-0297-4_8
Publisher Name: Humana Press, Totowa, NJ
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