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Vaccine, Drug, Antisense, and Third-Strand Therapies

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Abstract

Vaccination is a significant medical tool for the prevention of disease in humans and animals. The science and technology involved in developing vaccines has undergone an evolutionary progression from the crude cowpox viral preparations against the small pox virus first developed and used by Jenner nearly 200 years ago, to the highly advanced and pure recombinant protein vaccines pro duced by present day pharmaceutical manu facturers. The vaccines administered today are designed to be more effective and much safer to employ than previous preparations, and must go through rigorous safety and efficacy studies before being approved for human or veterinary use by the FDA or USDA, respectively. This revival in vaccine development was sparked by advances in genetic engineering that have produced recombinant protein antigens for use in vac cines, reducing the risks presently associ ated solely with the use of the earlier gen eration of attenuated live and killed organ ism vaccines. The utility of such novel and exciting technologies, as genetically engi neered monoclonal and catalytic antibod ies, and oligonucleotides that hybridize with and turn off intracellular pathogen nucleic acids, a procedure termed antisense therapy, is as yet still unclear, but almost certainly offer a revolutionary method of delivery for drugs against such intracellular pathogens as viruses. In addition, antisense technology holds high promise for use in the battle against cancer and genetic diseases.

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  1. Advanced Instruments Inc., Norwood, Massachusetts, USA

    Michael G. Pappas PhD

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© 1994 Springer Science+Business Media New York

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Pappas, M.G. (1994). Vaccine, Drug, Antisense, and Third-Strand Therapies. In: The Biotech Business Handbook. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0293-6_23

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  • DOI: https://doi.org/10.1007/978-1-4612-0293-6_23

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