Thyrotropin-Releasing Hormone (TRH)

Clinical Neuroendocrine and Neurobehavioral Findings of Relevance to Alcoholism
  • James C. Garbutt
  • Susan G. Silva
  • George A. Mason
Part of the Drug and Alcohol Abuse Reviews book series (DAAR, volume 6)

Abstract

Over the past twenty years, alcoholism and alcohol abuse have been identified as behavioral disorders that arise from an interaction between genetic (biological) and experiential/environmental factors.1 As more is learned about alcoholism, it is clear that an indeterminate number of distinct and separate subgroups of the illness exist.1,2 Advances in the understanding of the transmission of alcoholism and its heterogeneity have not as yet been matched by an understanding of the neurobiological basis for any form of alcoholism. Approaches to address this latter problem have included attempts to develop animal models of alcoholism, studies of the molecular and cellular actions of alcohol, studies of the neurobiological basis of drug-seeking behavior in animals, and studies of the biology of alcoholics and those at risk of developing alcoholism. The latter two strategies are the focus of this chapter.

Keywords

Placebo Depression Dopamine Cortisol Testosterone 

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References

  1. 1.
    C. R. Cloninger (1987) Neurogenetic adaptive mechanisms in alcoholism.Science236, 410–416.PubMedCrossRefGoogle Scholar
  2. 2.
    T. F. Babor, M. Hofman, F. K. DelBoca, V. Hesselbrock, R. E. Meyer, Z. S. Dolinsky, and B. Rounsaville (1992) Types of alcoholics, I: Evidence for an empirically derived typology based on indicators of vulnerability and severity.Arch. Gen. Psychiatry49, 599–608.PubMedCrossRefGoogle Scholar
  3. 3.
    J. C. Garbutt, P. T. Loosen, and A. J. Prange, Jr. (1993) Interrelationships between the hypothalamic—pituitary—thyroid axis and alcoholism, inThe Thyroid Axis and Psychiatric Illness. R. T. Joffe and A. J. Levitt eds., American Psychiatric Press, Washington, DC.Google Scholar
  4. 4.
    J. Leppaluato, M. Rapeli, R. Varis, and T. Ranta (1975) Secretion of anterior pituitary hormones in man: effects of ethyly alcohol.Acta Physiol. Scand.95, 400–406.CrossRefGoogle Scholar
  5. 5.
    R. H. Ylikahri, M. O. Huttunen, and M. Harkonen (1976) Effect of alcohol on anterior-pituitary secretion of trophic hormones.Lancet1, 1353.PubMedCrossRefGoogle Scholar
  6. 6.
    J. C. Garbutt, R. E. Hicks, C. J. Clayton, R. T. Andrews, and G. A. Mason (1991) Behavioral and endocrine interactions between thyrotropin-releasing hormone and alcohol in normal human subjects.Alcohol. Clin. Exp. Res.15, 1045–1049.PubMedCrossRefGoogle Scholar
  7. 7.
    D. H. Van Thiel, W. I. Smith, Jr., C. Wight, and J. Abuid (1979) Elevated basal and abnormal thyrotropin-releasing hormone-induced thyroid-stimulating hormone secretion in chronic alcoholic men with liver disease.Alcohol. Clin. Exp. Res.3, 302–308.PubMedCrossRefGoogle Scholar
  8. 8.
    S. Liljquist, S. Ahlenius, and J. Engel (1977) The effect of chronic alcohol treatment on behavior and central monoamines in the rat.Acta Pharmacol.300, 205–212.Google Scholar
  9. 9.
    P. T. Loosen, A. J. Prange, Jr., and I. C. Wilson (1979) TRH (Protirelin) in depressed alcoholic men.Arch. Gen. Psychiatry36, 540–547.PubMedCrossRefGoogle Scholar
  10. 10.
    J. Geurts, N. Demeester-Mirkine, D. Glinoer, T. Prigogine, J. Fernandez-DeVille, and J. Corvilain (1981) Alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism.Clin. Endocrino!.14, 113–118.CrossRefGoogle Scholar
  11. 11.
    M. Valimaki, R. Pelkonen, M. Harkonen, and R. H. Ylikahri (1984) Hormonal changes in noncirrhotic male alcoholics during alcohol withdrawal.Alcohol and Alcoholism19, 235–242.PubMedGoogle Scholar
  12. 12.
    S. Rojdmark, N. Adner, D. E. H. Andersson, J. Austern, and K. Lamminpaa (1984) Prolactin and thyrotropin responses to thyrotropin-releasing hormone and metoclopramide in men with chronic alcoholism.J. Clin. Endocrino!. Metab.59, 595–600.CrossRefGoogle Scholar
  13. 13.
    C. A. Dackis, J. Bailey, A. L. C. Pottash, R. F. Stuckey, I. L. Extein, and M. S. Gold (1984) Specificity of the DST and TRH test for major depression in alcoholics.Am. J. Psychiatry141, 680–683.PubMedGoogle Scholar
  14. 14.
    M. O’Hanlon, S. Barry, A. W. Clare, and T. G. Dinan (1991) Serum thyrotropin responses to thyrotropin-releasing hormone in alcohol-dependent patients with and without depression.J. Affective Disord.21, 109–115.CrossRefGoogle Scholar
  15. 15.
    J. A. Wainer, J. C. Garbutt, G. M. Gillette, G. A. Mason, and D. Quade (1991) Failure of chlordiazepoxide to antagonize the thyrotropin or prolactin response to thyrotropin-releasing hormone in humans.Neuroendocrinol. Lett.13, 431–436.Google Scholar
  16. 16.
    J. P. Roussel, H. Astier, and L. T. Tapia-Arancibia (1986) Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.Endocrinology119, 2519–2526.PubMedCrossRefGoogle Scholar
  17. 17.
    P. T. Loosen, I. C. Wilson, B. W. Dew, and A. Tipermas (1983) Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men.Am. J. Psychiatry140, 1145–1149.PubMedGoogle Scholar
  18. 18.
    M. Casacchia, A. Rossi, and P. Strata (1985) Thyrotropin-releasing hormone test in recently abstinent alcoholics.Psychiatry Res.16, 249–251.PubMedCrossRefGoogle Scholar
  19. 19.
    M. L. Willenbring, R. F. Anton, W. D. Spring, Jr., R. B. Shafer, and W. Dorus (1990) Thyrotropin and prolactin response to thyrotropin-releasing hormone in depressed and nondepressed alcoholic men.Biol. Psychiatry27, 31–38.PubMedCrossRefGoogle Scholar
  20. 20.
    J. C. Garbutt, J. P. Mayo, G. M. Gillette, K. Y. Little, R. E. Hicks, G. A. Mason, and A. J. Prange, Jr. (1991) Dose—response studies with thyrotropin-releasing hormone (TRH) in abstinent male alcoholics: evidence for selective thyrotroph dysfunction?J. Stud. Alcohol52, 275–280.PubMedGoogle Scholar
  21. 21.
    J. D. Sellman and P. R. Joyce (1992) The clinical significance of the thyrotropin-releasing hormone test in alcoholic men.Aust. NZ J.Psychiatry 26, 577–585.Google Scholar
  22. 22.
    D. L. Anderson, J. C. Nelson, M. G. Haviland, J. P. MacMurray, M. A. Cummings, W. H. McGhee, and R. W. Hubbard (1992) Thyroid stimulating hormone and prolactin responses to thyrotropin-releasing hormone in nondepressed alcoholic inpatients.Psychiatry Res.43, 121–128.PubMedCrossRefGoogle Scholar
  23. 23.
    D. M. Jacobowitz (1988) Multifactorial control of pituitary hormone secretion: the “wheels” of the brain.Synapse186–192.Google Scholar
  24. 24.
    P. R. Larsen (1982) Thyroid—pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones.N. Engl. J. Med.306, 23–32.PubMedCrossRefGoogle Scholar
  25. 25.
    J. C. Garbutt, J. McDavid, G. A. Mason, D. Quade, and P. T. Loosen (1992) Evidence for normal feedback inhibition of triiodothyronine on the thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) in abstinent male alcoholics.Alcohol. Clin. Exp. Res.16, 881–883.PubMedCrossRefGoogle Scholar
  26. 26.
    A. Roy, G. Bissette, C. B. Nemeroff, J. DeJong, B. Ravitz, B. Adinoff, and M. Linnoila (1990) Cerebrospinal fluid thyrotropin-releasing hormone concentrations in alcoholics and normal controls.Biol. Psychiatry28, 767–772.PubMedCrossRefGoogle Scholar
  27. 27.
    B. Adinoff, C. B. Nemeroff, G. Bissette, P. R. Martin, and M. Linnoila (1991) Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients.Am. J. Psychiatry148, 1586–1588.PubMedGoogle Scholar
  28. 28.
    M. C. Gershengorn (1978) Bihormonal regulation of the thyrotropin-releasing hormone receptor in mouse pituitary thyrotropic tumour cells in culture.J. Clin. Invest.62, 937–943.PubMedCrossRefGoogle Scholar
  29. 29.
    P. M. Hinkle and A. H. Tashjian Jr. (1975) Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture.Biochemistry14, 3845–3851.PubMedCrossRefGoogle Scholar
  30. 30.
    A. Mongioi, A. Aliffi, E. Vicari, F. Coniglione, U. Scapagnini, and R. D’Agata (1983) Downregulation of prolactin secretion in men during continuous thyrotropinreleasing hormone infusion: evidence for induction of pituitary desensitization by continuous TRH administration.J. Clin. Endocrinol. Metab.56, 904–907.PubMedCrossRefGoogle Scholar
  31. 31.
    M. M. Rabello, P. J. Snyder, and R. D. Utiger (1974) Effects on the pituitary—thyroid axis and prolactin secretion of single and repetitive oral doses of thyrotropinreleasing hormone (TRH).J. Clin. Endocrinol. Metab.39, 571–578.PubMedCrossRefGoogle Scholar
  32. 32.
    K. Maeda, Y. Yoshimoto, and A. Yamadori (1993) Blunted TSH and unaltered PRL responses to TRH following repeated administration of TRH in neurologic patients: a replication of neuroendocrine features of major depression.Biol. Psychiatry33, 277–283.PubMedCrossRefGoogle Scholar
  33. 33.
    S. Radouco-Thomas, F. Garcin, M. R. V. Murthy, N. Faure, A. Lemay, J. C. Forest, and C. Radouco-Thomas (1984) Biological markers in major psychoses and alcoholism: phenotypic and genotypic markers.J. Psychiatr. Res.18, 513–539.PubMedCrossRefGoogle Scholar
  34. 34.
    H. B. Moss, S. Guthrie, and M. Linnoila (1986) Enhanced thyrotropin response to thyrotropin-releasing hormone in boys at risk for development of alcoholism.Arch. Gen. Psychiatry43,1137–1142.PubMedCrossRefGoogle Scholar
  35. 35.
    M. R. Garcia, N. D. Ryan, H. Rabinovitch, P. Ambrosini, J. Twomey, S. Iyenger, H. Novacenko, B. Nelson, and J. Puig-Antich (1991) Thyroid stimulating hormone response to thyrotropin in prepubertal depression.J. Am. Acad. Child Adoles. Psychiatry30, 398–406.CrossRefGoogle Scholar
  36. 36.
    M. G. Monteiro, M. Irwin, R. L. Hauger, and M. A. Schuckit (1990) TSH response to TRH and family history of alcoholism.Biol. Psychiatry27, 905–910.PubMedCrossRefGoogle Scholar
  37. 37.
    A. J. Prange, Jr., I. C. Wilson, P. P. Lara, L. B. Alltop, and G. R. Breese (1972) Effects of thyrotropin-releasing hormone in depression.LancetII, 999–1002.CrossRefGoogle Scholar
  38. 38.
    A. J. Kastin, R. H. Ehrensing, D. S. Schalch, and M. S. Anderson (1972) Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone.LancetII, 740–742.CrossRefGoogle Scholar
  39. 39.
    R. M. Nesse, G. C. Curtis, and G. M. Brown (1982) Phobic anxiety does not affect plasma levels of TSH in man.Psychoneuroendocrinology7, 69–74.PubMedCrossRefGoogle Scholar
  40. 40.
    P. T. Loosen (1985) The TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker.Psychoneuroendocrinology10, 237–260.PubMedCrossRefGoogle Scholar
  41. 41.
    J. C. Garbutt, J. P. Mayo, K. Y. Little, G. M. Gillette, G. A. Mason, and A. J. Prange, Jr. (1993)Differential Pituitary Response to TRH Among Men With Alcoholism Major Depression or No Psychopathology. Research Society on Alcoholism, Annual Meeting, Abstract #153.Google Scholar
  42. 42.
    C. M. Banki, G. Bissette, M. Arato, and C. B. Nemeroff (1988) Elevation of immunoreactive CSF TRH in depressed patients.Am. J. Psychiatry145, 1526–1531.PubMedGoogle Scholar
  43. 43.
    C. B. Nemeroff, P. W. Kalivas, R. N. Golden, and A. J. Prange, Jr. (1984) Behavioral effects of hypothalamic hypophysiotropic hormones, neurotensin, substance P and other neuropeptides.Pharmcol. Ther.24, 1–56.CrossRefGoogle Scholar
  44. 44.
    J. M. Cott, G. R. Breese, B. R. Cooper, T. S. Barlow, and A. J. Prange, Jr. (1976) Investigations into the mechanism of reduction of alcohol sleep by thyrotropin-releasing hormone (TRH).J. Pharmcol. Exp. Ther.196, 594–604.Google Scholar
  45. 45.
    T. J. McCown and G. R. Breese (1989) Mechanistic and functional divergence between thyrotropin-releasing hormone and RO 15–4513 interactions with alcohol.Alcohol. Clin. Exp. Res.13, 660–663.PubMedCrossRefGoogle Scholar
  46. 46.
    M. Linnoila, M. J. Mattila, P. Karhunen, E. Nuotto, and T. Seppala (1981) Failure of TRH and ORG 2766 hexapeptide to counteract alcoholic inebriation in man.Eur. J. Clin. Pharmacol.21, 27–32.PubMedCrossRefGoogle Scholar
  47. 47.
    J. Knutsen, L. O. Dolva, S. Skrede, R. Björklund, and J. Morland (1989) Thyrotropinreleasing hormone antagonism of alcohol inebriation.Alcohol. Clin. Exp. Res.13, 365–370.PubMedCrossRefGoogle Scholar
  48. 48.
    J. C. Garbutt, R. E. Hicks, C. Clayton, R. A. Andrews, and G. A. Mason (1992)Acute Effects of High-Dose Intravenous Thyrotropin-Releasing Hormone (TRH) on the Neurobehavioral Effects of Ethanol in Normal Men.Abstract, Research Society on Alcoholism.Google Scholar
  49. 49.
    A. Norberg, C. Larsson, E. Perdahl, and B. Winblad (1983) Changes in cholinergic activity in human hippocampus following chronic alcohol abuse.Pharmacol. Biochem. Behay.18(Suppl. 1), 397–400.CrossRefGoogle Scholar
  50. 50.
    T. Arendt, V. Bigl, A. Arendt, and A. Tennsted (1983) Loss of neurons in the nucleus basalis of Meynert in Alzheimer’s disease, paralysis agitans and Korsakoff’s disease.Acta Neuropathol.61, 101–108.PubMedCrossRefGoogle Scholar
  51. 51.
    S. E. Molchan, A. M. Mellow, B. A. Lawlor, H. J. Weingartner, R. M. Cohen, M. R. Cohen, and T. Sunderland (1990) TRH attenuates scopolamine-induced memory impairment in humans.Psychopharmacology100, 84–89.PubMedCrossRefGoogle Scholar
  52. 52.
    A. Khan, M. H. Mirolo, K. Claypoole, and D. Hughes (1993) Low-dose thyrotropin-releasing hormone in cognitively impaired alcoholics.Alcohol. Clin. Exp. Res.17, 791–796.PubMedCrossRefGoogle Scholar
  53. 53.
    R. Z. Litten and J. P. Allen (1991) Pharmacotherapies for alcoholism: promising agents and clinical issues.Alcohol. Clin. Exp. Res.15, 620–633.PubMedCrossRefGoogle Scholar
  54. 54.
    M. A. Schuckit and E. O. Gold (1988) A simultaneous evaluation of multiple markers of alcohol/placebo challenges in sons of alcoholics and controls.Arch. Gen. Psychiatry45, 211–216.PubMedCrossRefGoogle Scholar
  55. 55.
    A. H. Rezvani, J. C. Garbutt, K. Shimoda, P. L. Garges, D. S. Janowsky, and G. A. Mason (1992) Attenuation of alcohol preference in alcohol-preferring rats by a novel TRH analogue TA-0910.Alcohol. Clin. Exp. Res.16, 326–330.PubMedCrossRefGoogle Scholar
  56. 56.
    J. R. Volpicelli, A. I. Alterman, M. Hayashida, and C. P. O’Brien (1992) Naltrexone in the treatment of alcohol dependence.Arch. Gen. Psychiatry49, 876–880.PubMedCrossRefGoogle Scholar
  57. 57.
    S. S. O’Malley, A. J. Jaffe, G. Chang, R. S. Schottenfeld, R. E. Meyer, and B. Rounsaville (1992) Naltrexone and coping ills therapy for alcohol dependence: a controlled study.Arch. Gen. Psychiatry49, 881–887.PubMedCrossRefGoogle Scholar
  58. 58.
    C. B. Nemeroff and A. J. Prange, Jr. (1978) Peptides and psychoneuroendocrinology: a perspective.Arch. Gen. Psychiatry35, 999–1010.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • James C. Garbutt
  • Susan G. Silva
  • George A. Mason

There are no affiliations available

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