Neuroendocrine Responses to Ethanol in the Prepubertal Female Rat

  • W. Les Dees
  • Christopher L. Nyberg
  • Jill K. Hiney
Part of the Drug and Alcohol Abuse Reviews book series (DAAR, volume 6)


One of the most intriguing aspects of mammalian endocrinology is the complex synchronization of events that culminate in sexual maturity. The central nervous system plays a crucial role in bringing together these events by controlling both anterior pituitary function via the secretion of hypothalamic neuromodulators, and the ovary via pituitary hormone secretions and direct neural inputs. This being the case, a drug that is capable of affecting any one of these portions of the reproductive axis during development could cause serious manifestations to occur, which may affect the otherwise normal series of events leading to the onset of puberty. It is known that abuse of ethanol (ETOH) can cause reproductive endocrine problems in adult humans and laboratory animals, indicating that this is one such drug that has the potential to cause the same problems in adolescents. Many surveys indicate an alarming increase in adolescent and teenage ETOH abuse, which has sparked interest in learning more about the effects of ETOH on the sexual maturation process.


Vasoactive Intestinal Peptide Neuroendocrine Response Luteinizing Hormone Secretion Vaginal Opening Pregnant Mare Serum Gonadotropin 
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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • W. Les Dees
  • Christopher L. Nyberg
  • Jill K. Hiney

There are no affiliations available

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