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β-Cell Receptors

Mechanisms of Signal Transduction

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Book cover Molecular Biology of Diabetes

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Abstract

The secretion of insulin is closely regulated in vivo in order to maintain the plasma glucose concentration in a narrow range despite long periods of fasting and intermittent food intake. The regulation of insulin secretion has been studied extensively and involves a complex interaction of glucose and other nutrients, and endocrine, paracrine, and neurohumoral factors. The effects of these factors on insulin secretion are transduced by their interaction with specific receptor molecules on the surface of the β-cell. The physiologic role of many of these ligand-receptor interactions in altering insulin secretion has been clarified recently and their distal signaling mechanisms characterized.

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Authors
  1. Joseph S. Dillon
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  2. Ming Lu
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  3. Michael B. Wheeler
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  4. Aubrey E. Boyd III
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Editor information

Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Boris Draznin MD, PhD

  2. National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA

    Derek LeRoith MD, PhD

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© 1994 Springer Science+Business Media New York

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Dillon, J.S., Lu, M., Wheeler, M.B., Boyd, A.E. (1994). β-Cell Receptors. In: Draznin, B., LeRoith, D. (eds) Molecular Biology of Diabetes. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0241-7_12

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  • DOI: https://doi.org/10.1007/978-1-4612-0241-7_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6677-8

  • Online ISBN: 978-1-4612-0241-7

  • eBook Packages: Springer Book Archive

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