Vascular Actions of Insulin in Health and Disease

Role of the Endothelium
  • Alain D. Baron
  • Helmut O. Steinberg
Part of the Contemporary Endocrinology book series (COE, volume 1)

Abstract

Insulin has specific and physiologic cardiovascular actions in humans, and causes an increase in skeletal muscle blood flow (SMBF) and a fall in vascular resistance. In this chapter, the physiologic role of insulin-induced skeletal muscle vasodilation and its mechanism including the interaction between insulin and the endothelium to modulate the endothelium-derived nitric oxide (NO) system are reviewed. Finally, the effect of insulin resistance on the vascular actions of insulin is also explored. The latter has important clinical consequences given that insulin resistance is a common feature of obesity, of noninsulin-dependent diabetes mellitus (NIDDM), and hypertension, and is associated with an increased risk of macrovascular disease (1,2)

Keywords

Obesity Arginine Norepinephrine Acetylcholine Hyperglycemia 

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Alain D. Baron
  • Helmut O. Steinberg

There are no affiliations available

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