Skip to main content
SpringerLink
Log in

C-Type Natriuretic Peptide

The Vascular Component of the Natriuretic Peptide System

  • Chapter
Endocrinology of the Vasculature

Part of the book series: Contemporary Endocrinology ((COE,volume 1))

Abstract

Atrial natriuretic peptide (ANP) is a 28 amino acid ringed structure peptide of myocardial cell origin (1). ANP mediates natriuresis, renin-inhibiting, vasodilatory, and antimitogenic properties through actions of particulate.guanylyl cyclase and the second messenger guanosine 3’,5’-monophosphate (cGMP)(2 3). Brain natriuretic peptide (BNP) shares similar biological actions with ANP, is structurally similar (but genetically distinct), and functions via activation of the same biologically active receptor(3). ANP and BNP form a dual cardiac peptide endocrine system in which these two peptides function as circulating hormones in the control of intravascular volume and arterial pressure(4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. DeBold AJ, Borenstein HB, Veress AT, Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 1981;28:89–94.

    Article  CAS  Google Scholar 

  2. Burnett JC Jr, Granger JP, Opgenorth TF. Effects of synthetic atrial natriuretic factor on renal function and renin release. Am J Physiol 1984;247:F863–F866.

    PubMed  CAS  Google Scholar 

  3. Koller KJ, Goeddel DV. Molecular biology of the natriuretic peptides and their receptors. Circulation 1992;86:1081–1088.

    Article  PubMed  CAS  Google Scholar 

  4. Mukoyama M, Nakao K, Hosoda K, Suga K, Saitu Y, Ogawa Y, Shiralrami G, Jougasaki M, Obata K, Yasue H, Kambayashi Y, Inouye K, Imura H. Brain natriuretic peptide as novel cardiac hormone in humans: evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest 1991;87:1402–1412.

    Article  PubMed  CAS  Google Scholar 

  5. Sudoh TN, Minamino N, Kangawa K, Matsuo H. C-type natriuretic peptide (CNP), a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 1990;168:863–870.

    Article  PubMed  CAS  Google Scholar 

  6. Heublein DM, Clavell AL, Lerman A, Wold L, Burnett JC Jr. C-type natriuretic peptide immunoreactivity in human breast vascular endothelial cells. Peptides 1992;13:1017–1019.

    Article  PubMed  CAS  Google Scholar 

  7. Suga S, Nakao K, Itoh H, Kamatsu Y, Ogawa Y, Hama H, Imura H. Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-ß. J Clin Invest 1992;90:1145–1149.

    Article  PubMed  CAS  Google Scholar 

  8. Stingo AJ, Clavell AL, Heublien DM, Wei CM, Pittelkow MR, Burnett JC, Jr. Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Physiol 1992;263(Heart Circ Physiol 32):H1318–H1321.

    PubMed  CAS  Google Scholar 

  9. Nakao K, Ogawa Y, Suga S, Imura H. Molecular biology and biochemistry of the natriuretic peptide system I: natriuretic peptides. J Hypertens 1992;10:907–912.

    PubMed  CAS  Google Scholar 

  10. Tawaragi Y, Fuchimura K, Tanaka S, Minamino N, Kangawa K, Matsuo H. Gene and precursor structures of human C-type natriuretic peptide. Biochem Biophys Res Commun 1991;175:645–651.

    Article  PubMed  CAS  Google Scholar 

  11. Ogawa Y, et al. Human C-type natriuretic peptide: characterization of the gene and peptide. Hypertension 1992;19:809–813.

    Article  PubMed  CAS  Google Scholar 

  12. Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K. Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC). Genomics 1994;24:383–387.

    Article  PubMed  CAS  Google Scholar 

  13. Minamino N, Kangawa K, Matsuo H. N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain. Biochem Biophys Res Commun 1990;170:973–979.

    Article  PubMed  CAS  Google Scholar 

  14. Wilkins MR, Needleman P. Effect of pharmacologie manipulation of endogenous atriopeptin activity on renal function. Am J Physiol 1992;262(Renal Fluid Electrolyte Physiol 31):F161–F167.

    PubMed  CAS  Google Scholar 

  15. Chinkers M, Garbers DL. The protein kinase domain of the ANP receptor is required for signalling. Science 1989;245:1392.

    Article  PubMed  CAS  Google Scholar 

  16. Koller K, deSauvage FJ, Lowe DG, Goeddel DV. Conservation of the kinase like domain is essential for activation of the natriuretic peptide receptor guanylyl cyclases. Mol Cell Biol 1992;12:2581–2590.

    PubMed  CAS  Google Scholar 

  17. Koller KJ, Lowe DG, Bennett GL, Minamino N, Goeddel DV, et al. Selective activation of the B-natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science Washington DC 1991; 252:120–123.

    Article  CAS  Google Scholar 

  18. Suga SK, Nakao K, Mukoyama Y, Ogawa T, Shirakami G, Kambayashi Y, Inouye K, Imura H. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide. Endocrinology 1992;130:229–239.

    Article  PubMed  CAS  Google Scholar 

  19. Maack T. Receptors of atrial natriuretic factor. Annu Rev Physiol 1992;54:11–27.

    Article  PubMed  CAS  Google Scholar 

  20. Nusseinzveig DR, Lewicki J, Maack T. Cellular mechanisms of the clearance function of type C receptors of atrial natriuretic factor. J Biol Chem 1990;265:20,952.

    Google Scholar 

  21. Hirata M, Chang CH, Murad F. Stimulatory effects of atrial natriuretic factor on phosphoinositide hydrolysis in cultured bovine aortic smooth muscle cells. Biochem Biophys Acta 1989;10:346–351.

    Google Scholar 

  22. Anandsrivatsva MB, Sairam MR, Cantin M. Ring deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/c AMP system. J Biol Chem 1990;265:8566–8572.

    Google Scholar 

  23. Drewett JG, Ziegler RJ, Trachte GJ. Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase. J Pharm Exp Ther 1992;260:689–696.

    CAS  Google Scholar 

  24. Levin ER. Natriuretic peptide C receptor: more than a clearance receptor. Am J Physiol 1993;264: E483–489.

    PubMed  CAS  Google Scholar 

  25. Levin ER, Frank HL. Natriuretic peptides inhibit astroglial cell proliferation: mediation by C-receptor. Am J Physiol 1990;261:R453–R457.

    Google Scholar 

  26. Tallerco-Melnyk T, Yip CC, Watt VM. Widespread co-localization of mRNAs encoding the guanylate cyclase coupled natriuretic peptide receptors in rat tissues. Biochem Biophys Res Commun 1992;189:610–616.

    Article  Google Scholar 

  27. Nunez DJR, Dickson MC, Brown MJ. Natriuretic peptide receptor mRNAs in the rat and human heart. J Clin Invest 1992;90:1966–1971.

    Article  PubMed  CAS  Google Scholar 

  28. Canaankuhl S, Jamison RL, Myers BD, Pratt RE. Identification of `B“ receptor for natriuretic peptide in human kidney. Endocrinology 1992;130:550–552.

    Article  CAS  Google Scholar 

  29. Komatsu Y, Nakao K, Itoh H, Suga S, Ogawa Y, Imura H. Vascular natriuretic peptide system in humans (Letter). Lancet 1992;340:622.

    Article  PubMed  CAS  Google Scholar 

  30. Popescu LM, Panoiu C, Hinescu M, Nutu O. The mechanism of cGMP-induced relaxation in VSMC. Eur J Pharmacol 1985;107:393,394.

    Article  Google Scholar 

  31. Cornwell TL, Pryzwansky KB, Lincoln TM. Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in VSMCs. Mol Pharmacol 1991;40:923–931.

    PubMed  CAS  Google Scholar 

  32. Furukawa KI, Ohshima N, Tawada-Iwata Y, Shigekawa M. Cyclic GMP stimulates Na/Ca exchange in VSMCs in primary culture. J Biol Chem 1991;266:12,337–12,341.

    PubMed  CAS  Google Scholar 

  33. O’Donnell ME, Owen NE. Atrial natriuretic factor stimulates Na/K/Cl cotransport in VSMCs. Proc Natl Acad Sci USA 1986;83:6132–6136.

    Article  PubMed  Google Scholar 

  34. Mery PF, Lohman SM, Fischmeister R. Ca current is regulated by cyclic GMP dependent protein kinase in mammalian cardiac myocytes. Proc Natl Acad Sci USA 1991;88:1197–1201.

    Article  PubMed  CAS  Google Scholar 

  35. Meisherei KD, Taylor CJ, Saneii H. Synthetic atrial peptide inhibits intracellular Cat+release in smooth muscle. Am J Physiol 1986;250:C171–C174.

    Google Scholar 

  36. Hirata M, Kohse KP, Chang CH, Ikebe T, Murad F. Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells. J Biol Chem 1990;265:1268–1273.

    PubMed  CAS  Google Scholar 

  37. Winquist RJ, Faison EP, Waldman SA, Schwartz K, Murad F, Rapoport RM. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates perticulate guanylate cyclase in VSMC. Proc Natl Acad Sci USA 1984;81:7661–7664.

    Article  PubMed  CAS  Google Scholar 

  38. Lincoln TM. Cyclic GMP and mechanisms of vasodilation. Pharmacol Ther 1989;41:479–502.

    Article  PubMed  CAS  Google Scholar 

  39. Yandle TG. Biochemistry of natriuretic peptides. J Int Med 1994;235:561–576.

    Article  CAS  Google Scholar 

  40. Edwards BS, Zimmerman RS, Schwab RR, Heublein DM, Burnett JC Jr. Atrial stretch, not pressure is the principal determinant controlling the acute release of atrial natriuretic factor. Circ Res 1988; 62:191–195.

    Article  PubMed  CAS  Google Scholar 

  41. Espiner EA. Physiology of natriuretic peptides. J Int Med 1994;235:527–541.

    Article  CAS  Google Scholar 

  42. Nazario B, Hu RM, Pedram A, Prins B, Levin ER. Atrial and brain natriuretic peptides stimulate the production and secretion of C-type natriuretic peptide from bovine aortic endothelial cells. J Clin Invest 1995;95:1151–1157.

    Article  PubMed  CAS  Google Scholar 

  43. Suga S, Itoh H, Komatsu Y, Ogawa Y, Hama N, Yoshimasa T, Nakao K. Cytokine induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells: evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells. Endocrinology 1993;133:3038–3041.

    Article  PubMed  CAS  Google Scholar 

  44. Wennberg PW, Wei CM, Miller VM, Kinoshita MM, Burnett JC Jr. Vascular acions of a natriuretic peptide receptor and particulate guanylate cyclase inhibitor upon isolated canine coronary arteries. Circulation 1994;90:I112.

    Google Scholar 

  45. Furuya M, Takehisa M, Minamitake Y, Kitajima Y, Hayashi Y. Novel natriuretic peptide, CNP, potently stimulates cyclic GMP production in rat cultured VSMCs. Biochem Biophys Res Commun 1990; 170:201–208.

    Article  PubMed  CAS  Google Scholar 

  46. Furuya M, Yoshida M, Minamino N, Kangawa K, Matsuo H. C-type natriuretic peptide is a growth inhibitor of rat VSMCs. Biochem Biophys Res Commun 1991;177:927–931.

    Article  PubMed  CAS  Google Scholar 

  47. Porter JG, Protter AA. C-type natriuretic peptide inhibits growth factor-dependent DNA synthesis in smooth muscle cells. Am J Physiol 1992;263:C1001–1006.

    PubMed  CAS  Google Scholar 

  48. Wei C, Hu S, Miller V, Burnett JC Jr. Vascular actions of C-type natriuretic peptide in isolated porcine coronary arteries and coronary VSMCs Biochem Biophys Res Commun 1994;205:765–771.

    Article  PubMed  CAS  Google Scholar 

  49. Wie CM, Aarhus LL, Miller VM, Burnett JC Jr. Action of C-type natriuretic peptide in isolated canine arteries and veins. Am J Physiol 1993;264:H71–H73.

    Google Scholar 

  50. Wei C, Hu S, Miller V, Burnett JC Jr. Vascular actions of C-type natriuretic peptide in isolated porcine coronary arteries and coronary VSMCs. Biochem Biophys Res Commun 1994;205:765–771.

    Article  PubMed  CAS  Google Scholar 

  51. Vanhoulte PM, Cohen RA. Endothelium dependent hyperpolarization: beyond NO and cyclic GMP. Circulation 1996;2:3337–3749.

    Google Scholar 

  52. White RE, Lee AB, Scherbatko AD, Lincoln TM, Schonburnn A, Armstrong DL. K+channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation. Nature 1993;361:263–266.

    Article  PubMed  CAS  Google Scholar 

  53. Stingo AJ, Clavell A, Aarhus L, Burnett JC Jr. Cardiovascular and renal actions of C-type natriuretic peptide. Am J Physiol 1992;262(Heart Circ Physiol 31):H308–H312.

    PubMed  CAS  Google Scholar 

  54. Hunt PJ, Yandle TG. Bioactivity and metabolism of C-type natriuretic peptide in normal man. J Clin Endocrinol Metab 1994;78:1428–1435.

    Article  PubMed  CAS  Google Scholar 

  55. Marumo T, Nakaki T, Hishikawa K, Hirahashi J, Suzuki H, Kato R, Saruta T. Natriuretic peptide-augmented induction of NO synthase through cyclic guanosine 3’,5’-monophosphate elevation in VSMCs. Endocrinology 1995;136:2135–2142.

    Article  PubMed  CAS  Google Scholar 

  56. Kohno M, Horio T, Yokokawa K, Kurihara N, Takeda T. C-type natriuretic peptide inhibits thrombin and All stimulated ET-1 release via cyclic guanosine 3’,5’-monophosphate. Hypertension 1992;19:320–325.

    Article  PubMed  CAS  Google Scholar 

  57. Vigne P, Lund L, Frelin C. Cross talk among cyclic AMP, cyclic GMP, and Ca+2-dependent intracellular signalling mechanisms in brain capillary endothelium. J Neurochem 1994;62:2269–2274.

    Article  PubMed  CAS  Google Scholar 

  58. Nir A, Clavell AL, Aarhus LL, Burnett JC Jr. The modulating effect of C-type natriuretic peptide on the hemodynamic actions of ET-1. Am J Hypertens I993;6:74A.

    Google Scholar 

  59. Dussaule JC, Stefanski A, Bea ML, Ronco P, Ardailou R. Characterization of neutral endopeptidase in VSMCs of rabbit renal cortex. Am J Physiol 1993;264:F45–F52.

    PubMed  CAS  Google Scholar 

  60. Graf K, Koehne P, Grafe M, et al. Regulation and expression of neutral endopeptidase 24.11 in human endothelial cells. Hypertension 1995;26:230–235.

    Article  PubMed  CAS  Google Scholar 

  61. Charles CJ, Richards AM, Espiner EA. Central C-type natriuretic peptide but not atrial natriuretic factor lowers blood pressure and adrenocortical secretion in normal conscious sheep. Endocrinology 1992;131:721–726.

    Article  Google Scholar 

  62. Trachte GJ, Drewett JG. C-type natriuretic peptide neuromodulates independently of guanylyl cyclase activation. Hypertension 1994;23:38–43.

    Article  PubMed  CAS  Google Scholar 

  63. Wei CM, Burnett JC Jr. Atrial natriuretic peptide and CNP in spontaneously hypertensive rats and their vasorelaxing actions in vivo. Hypertension 1994;23(Part 2):903–907.

    Article  PubMed  CAS  Google Scholar 

  64. Dartsch PC. In vitro growth characteristics of human atherosclerotic plaque cells: comparison of cells from primary stenosing and restenosing lesions of peripheral and coronary arteries. Res Exp Med 1990;190:77–87.

    Article  CAS  Google Scholar 

  65. Suga S, Nakao K. Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells. Circ Res 1992;71:34–39.

    Article  PubMed  CAS  Google Scholar 

  66. Brown J, Chen Q. Regional expression of natriuretic peptide receptors during the formation of arterial neointima in the rabbit. Circ Res 1995;77:906–918.

    Article  PubMed  CAS  Google Scholar 

  67. Wei CM, Heublein DM, Kao PC, Edwards WD, Burnett JC Jr. Natriuretic peptide system in human heart failure. Circulation 1993;88:1004–1009.

    Article  PubMed  CAS  Google Scholar 

  68. Nakamura M, Arakawa N, Yoshida H, Makita S, Hiramori K. Vasodilatory effects of C-type natriuretic peptide in forearm resistance vessels are distinct from those of atrial natriuretic peptide in chronic heart failure. Circulation 1994;90:1210–1214.

    Article  PubMed  CAS  Google Scholar 

  69. Hama N, Itoh H, Shirakami G, Suga S, Komatsu Y, Yoshimasa T, Tanaka I, Mori K, Nakas K. Detection of C-type natriuretic peptides in human circulation and marked increase of plasma CNP level on septic shock patients. Biochem Biophys Res Commun 1994;198:1177–1182.

    Article  PubMed  CAS  Google Scholar 

  70. Kugiyama K, Sugiyama S, Matsumura T, Yasutaka O. Increased activity of neutral endopeptidase 24.11 inhibits relaxations in response to C-type natriuretic peptide in atherosclerotic arteries. Circulation 1994;90:I-36.

    Google Scholar 

  71. Kugiyama K, Sugiyama S, Matsumura T, Yasue H. Suppression of atherosclerotic changes in cholesterol fed rabbits treated with an oral inhibitor of neutral endopeptidase 24.11. Circulation 1993;88:I-521.

    Google Scholar 

  72. Kullo IJ, Muller VM, Lawson GM, Burnett JC Jr. Dual inhibition of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) suppresses atherogenesis and improves endothelial function in hypercholestemic rabbits. J Am Coll Cardiol 1996;27(2 Suppl. A):164A.

    Article  Google Scholar 

  73. Furuya M, Aisaka K, Miyazaki T, Honbou N, Kawashima K, Ohno T, Tanaka S, Minamino H, Kangawa K, Matsuo H. C-type natriuretic peptide inhibits intimal thickening after vascular injury. Biochem Biophys Res Commun 1993;193:248–253.

    Article  PubMed  CAS  Google Scholar 

  74. Morishita R, Gibbons GH, Pratt RE, Tomita N, Dzau VJ. Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on VSMCs and endothelial cellular growth. J Clin Invest 1994;94:824–829.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Iftikhar J. Kullo MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John C. Burnett Jr. MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Medicine, Wayne State University, Detroit, Michigan, USA

    James R. Sowers MD

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kullo, I.J., Burnett, J.C. (1996). C-Type Natriuretic Peptide. In: Sowers, J.R. (eds) Endocrinology of the Vasculature. Contemporary Endocrinology, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0231-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-0231-8_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6672-3

  • Online ISBN: 978-1-4612-0231-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation