Abstract
Diatomic oxygen is an essential molecule of the biological process. The two electron reduction of molecular oxygen to water catalyzed by the enzyme cytochrome oxidase drives respiration in virtually all cells with the concomitant production of ATP necessary for intracellular enzymatic reactions [1]. The single electron reduction of oxygen can lead to several active oxygen species which can serve as important mediators of host defense reactions [2], but can also lead to substantial tissue damage including the oxidation of lipids (lipid peroxidation) [3], DNA damage [4], and irreversible alteration of proteins [5]. It is not surprising that a great deal of interest has centered around the generation of oxygen free radical species and the role that such species play, ranging from killing of bacteria [2] to their role in diseases [6] such as atherosclerosis, ischemia-reperfusion injury, and inflammatory diseases as well as cancer and aging.
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Murphy, R.C., Harrison, K.A. (1996). Isoeicosanoids: Mass Spectrometry of Free Radical Oxidation Products Derived From Arachidonoyl Phospholipids. In: Burlingame, A.L., Carr, S.A. (eds) Mass Spectrometry in the Biological Sciences. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0229-5_23
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DOI: https://doi.org/10.1007/978-1-4612-0229-5_23
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