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Growth Factor Regulation of Physiologic Angiogenesis in the Mammary Gland

  • Anne Saaristo
  • Marika J. Karkkainen
  • Kari Alitalo
  • Roberto Montesano
  • M. Luisa Iruela-Arispe
  • Michael S. Pepper
Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)

Abstract

During embryogenesis, the formation of new blood vessels occurs via two processes: vasculogenesis and angiogenesis. Vasculogenesis involves the de novo differentation of endothelial cells from mesoderm-derived precursors called angioblasts, which then cluster and reorganize to form capillary-like tubes (Risau and Flamme, 1995). Once the primary vascular plexus is formed, new capillaries form by sprouting or by splitting (intussusception) from preexisting capillaries in the processes called sprouting or nonsprouting angiogenesis, respectively (Risau, 1997). In postnatal life, the growth of normal as well as neoplastic tissues depends on angiogenesis. Angiogenesis is particularly important for normal reproductive function, including the cyclical growth of capillaries within the ovary (required for ovulation and corpus luteum formation) and the endometrium (required for regeneration following menstruation). Angiogenesis also occurs following implantation of the blastocyst, and is required for the formation of the placenta (Findlay, 1986). This chapter discusses the role of physiologic angiogenesis and angiogenic growth factors in relation to mammary gland function.

Keywords

Vascular Endothelial Growth Factor Mammary Gland Hepatocyte Growth Factor Lymphatic Vessel Vascular Endothelial Growth Factor mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Anne Saaristo
  • Marika J. Karkkainen
  • Kari Alitalo
  • Roberto Montesano
  • M. Luisa Iruela-Arispe
  • Michael S. Pepper

There are no affiliations available

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