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Growth Factor Regulation of Physiologic Angiogenesis in the Mammary Gland

  • Chapter
Vascular Morphogenesis in the Female Reproductive System

Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

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Abstract

During embryogenesis, the formation of new blood vessels occurs via two processes: vasculogenesis and angiogenesis. Vasculogenesis involves the de novo differentation of endothelial cells from mesoderm-derived precursors called angioblasts, which then cluster and reorganize to form capillary-like tubes (Risau and Flamme, 1995). Once the primary vascular plexus is formed, new capillaries form by sprouting or by splitting (intussusception) from preexisting capillaries in the processes called sprouting or nonsprouting angiogenesis, respectively (Risau, 1997). In postnatal life, the growth of normal as well as neoplastic tissues depends on angiogenesis. Angiogenesis is particularly important for normal reproductive function, including the cyclical growth of capillaries within the ovary (required for ovulation and corpus luteum formation) and the endometrium (required for regeneration following menstruation). Angiogenesis also occurs following implantation of the blastocyst, and is required for the formation of the placenta (Findlay, 1986). This chapter discusses the role of physiologic angiogenesis and angiogenic growth factors in relation to mammary gland function.

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Authors
  1. Anne Saaristo
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  2. Marika J. Karkkainen
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  3. Kari Alitalo
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  4. Roberto Montesano
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  5. M. Luisa Iruela-Arispe
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  6. Michael S. Pepper
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Editor information

Editors and Affiliations

  1. Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, D-79106, Germany

    Hellmut G. Augustin

  2. Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria, 3168, Australia

    Peter A. W. Rogers

  3. Molecular Biology Institute, University of California, Los Angeles, CA, 90095-1570, USA

    M. Luisa Iruela-Arispe

  4. Department of Obstetrics and Gynaecology, Rosie Maternity Hospital, Cambridge, CB2 2SW, England

    Stephen K. Smith

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Saaristo, A., Karkkainen, M.J., Alitalo, K., Montesano, R., Iruela-Arispe, M.L., Pepper, M.S. (2001). Growth Factor Regulation of Physiologic Angiogenesis in the Mammary Gland. In: Augustin, H.G., Rogers, P.A.W., Iruela-Arispe, M.L., Smith, S.K. (eds) Vascular Morphogenesis in the Female Reproductive System. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0213-4_2

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  • DOI: https://doi.org/10.1007/978-1-4612-0213-4_2

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-6665-5

  • Online ISBN: 978-1-4612-0213-4

  • eBook Packages: Springer Book Archive

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