Placenta Growth Factor

  • M. Graziella Persico
Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)


The search for regulators of angiogenesis has led to the identification of a number of genes that, when tested in vitro or in vivo (in animal models), help to elucidate the complex phenomenon of vascular formation during development and pathologic conditions. Many new growth factors and receptors and other molecules previously thought to be specific for other systems (e.g., the nervous system) have now been found to play a role in angiogenesis and are currently under analysis. One such example is neuropilin-1, which is expressed predominantly in developing neurons (for a review see Fujisawa and Kitsukawa, 1998). Neuropilin-1 null mutants die during embryonic development due to disorganization of nerve pathways (Kitsukawa et al, 1997) as well as several vascular defects (Kawasaki et al, 1999).


Vascular Endothelial Growth Factor Human Umbilical Vein Endothelial Cell Vascular Endothelial Growth Factor Gene Vascular Endothelial Cell Growth Factor Extravillous Trophoblast 
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© Springer Science+Business Media New York 2001

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  • M. Graziella Persico

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