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Vascular Morphogenesis in the Female Reproductive System pp 245–270Cite as

Birkhäuser

Angiogenesis in Endometriosis

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Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

Abstract

Endometriosis is a common gynecologic disorder defined by the presence, growth, and progression of endometrial tissue outside the uterine cavity. Endometriosis can be asymptomatic, but it typically is associated with a multitude of clinical symptoms, the most common being pelvic pain and impaired fertility. The disease affects about 10% of all reproductive-age women and the prevalence rises to 20% to 50% in infertile women. Genes seem to influence liability to endometriosis (Treloar et al, 1999); however, the mode of hereditary transmission appears to be multifactorial (Malinak et al, 1980). Retrograde menstruation and increased exposure to menstrual flow (reduced parity, longer duration of menstrual periods, or shorter cycle length) have been identified as risk factors for endometriosis. Recently, environmental factors, in particular dioxin (Rier et al, 1993) and other presumed endocrine disrupters have been implicated in its development.

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Authors
  1. Michael D. Mueller
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  2. Robert N. Taylor
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Editors and Affiliations

  1. Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, D-79106, Germany

    Hellmut G. Augustin

  2. Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria, 3168, Australia

    Peter A. W. Rogers

  3. Molecular Biology Institute, University of California, Los Angeles, CA, 90095-1570, USA

    M. Luisa Iruela-Arispe

  4. Department of Obstetrics and Gynaecology, Rosie Maternity Hospital, Cambridge, CB2 2SW, England

    Stephen K. Smith

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Mueller, M.D., Taylor, R.N. (2001). Angiogenesis in Endometriosis. In: Augustin, H.G., Rogers, P.A.W., Iruela-Arispe, M.L., Smith, S.K. (eds) Vascular Morphogenesis in the Female Reproductive System. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0213-4_13

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  • DOI: https://doi.org/10.1007/978-1-4612-0213-4_13

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