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Angiogenesis in Endometriosis

  • Michael D. Mueller
  • Robert N. Taylor
Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)

Abstract

Endometriosis is a common gynecologic disorder defined by the presence, growth, and progression of endometrial tissue outside the uterine cavity. Endometriosis can be asymptomatic, but it typically is associated with a multitude of clinical symptoms, the most common being pelvic pain and impaired fertility. The disease affects about 10% of all reproductive-age women and the prevalence rises to 20% to 50% in infertile women. Genes seem to influence liability to endometriosis (Treloar et al, 1999); however, the mode of hereditary transmission appears to be multifactorial (Malinak et al, 1980). Retrograde menstruation and increased exposure to menstrual flow (reduced parity, longer duration of menstrual periods, or shorter cycle length) have been identified as risk factors for endometriosis. Recently, environmental factors, in particular dioxin (Rier et al, 1993) and other presumed endocrine disrupters have been implicated in its development.

Keywords

Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Expression Peritoneal Fluid Vascular Endothelial Growth Factor mRNA Ovarian Steroid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Michael D. Mueller
  • Robert N. Taylor

There are no affiliations available

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