The Clinical Relevance of Disturbances of Uterine Vascular Growth, Remodeling, and Repair

  • Martha Hickey
  • Ian S. Fraser
Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)


Endometrial blood vessels are unique in the manner in which they undergo monthly cycles of dramatic growth, disruption, remodeling, and repair, rivaled only by the remarkable vascular growth and regression occurring during formation and subsequent demise of the ovarian corpus luteum. In the normal menstrual cycle the regular endometrial vascular and tissue disruption and remodeling is associated with frank bleeding known as menstruation. The volume and duration of this bleeding is generally very precisely controlled by a number of fail-safe mechanisms. The overall cyclical changes occurring in endometrium are regulated by a complex sequence of interacting cellular and molecular processes. Any of these processes may be disturbed under certain circumstances.


Vascular Endothelial Growth Factor Uterine Fibroid Menstrual Bleeding Human Endometrium Normal Menstrual Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Martha Hickey
  • Ian S. Fraser

There are no affiliations available

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