The Vascular System in the Endometrium: Introduction and Overview

  • Peter A. W. Rogers
  • Caroline E. Gargett
Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)


The chapters in this section describe endometrial vascular structure and function, with particular emphasis on normal physiologic events such as growth, implantation, and menstruation, as well as pathologic situations such as endometriosis, menorrhagia, breakthrough bleeding, adenomyosis, and fibroids. The role that estrogen and progesterone play in regulating the endometrial vasculature during these processes is discussed, as are various other factors that regulate vascular function at a local level. The recent sudden increase in understanding of how blood vessel growth and regression is regulated, coupled with the major involvement of uterine vasculature in almost all clinically relevant gynecologic disorders, has opened exciting new possibilities for medical treatment. The challenge for scientists and clinicians working in this field will be to harness the promise that this knowledge brings to develop effective new therapies. Possible novel treatments that could be considered include use of angiogenesis inhibitors to prevent endometriosis, and vessel stabilization and maturation factors to reduce vessel fragility and breakthrough bleeding. The latest information in this rapidly developing field is detailed in the chapters in this section, with contributions from three of the leading groups currently working on different aspects of the regulation of endometrial vascular structure and function.


Vascular Endothelial Growth Factor Progesterone Receptor Menstrual Cycle Secretory Phase Endothelial Cell Proliferation 
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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Peter A. W. Rogers
  • Caroline E. Gargett

There are no affiliations available

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