Abstract
Fundamental to the differentiation and morphogenesis of any organ is the interaction between its component cells and the extracellular matrix (ECM). In the early 1980s, the concept of dynamic reciprocity was introduced (Bissell et al, 1982), which proposed that the ECM produced by cells was in turn critical in the regulation of gene expression by these same cells. Studies to date, especially with isolated cells, have shown that the ECM has a profound influence on many cellular processes including the regulation of gene expression (for recent reviews, see Aumailley and Gayraud, 1998; Mauch, 1998). However, it is not yet known how these in vitro results relate to the development of the heart in vivo. The past 20 years have yielded an explosion of papers on this topic, which clearly document the importance of cell-ECM interactions in modulating fundamental cell properties such as differentiation, proliferation, migration, adhesion, and even survival. All of these biologic events are essential to the formation of tissues and organs including those within the cardiovascular system. This chapter focuses on how the components of the ECM influence the formation and function of the heart.
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Goldsmith, E.C., Carver, W., Borg, T.K. (2001). The Role of the Extracellular Matrix and Its Receptors in Modulating Cardiac Development. In: Tomanek, R.J., Runyan, R.B. (eds) Formation of the Heart and Its Regulation. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0207-3_9
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