Molluscum contagiosum virus causes a benign and self-limited infection with a classic umbilicated papular manifestation in children, sexually active adults, and immunocompromised individuals. While several classes of therapy are available including physical therapy, chemical destructive therapy, chemical non-destructive therapy, immune modulators, and antiviral therapy, cryosurgery offers the advantage of high-eradication rates and is a relatively quick office procedure. It can be performed in several freeze-thaw cycles, each with 10–20 second long bursts of liquid nitrogen spray. Adverse effects include mild pain with application, blister and scar formation, and hypopigmentation. Along with various effective chemical treatments, cryosurgery should be considered a first-line therapy for the treatment and eradication of MCV infection.
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