Skip to main content

Locked in or Break Out?

  • Chapter
Stroke Medicine

Abstract

Basilar artery occlusion accounts for approximately 1 % of all strokes and is a neurological emergency associated with a very poor outcome. The associated mortality is up to 90 %. Basilar artery occlusion can initially present with mild prodromal symptoms however this is usually followed by more devastating symptoms including quadriparesis, reduced consciousness, cranial nerve and visual symptoms, dysarthria, dysphagia and ‘locked-in syndrome’. These cases are challenging because there is limited evidence to guide physicians in their management decisions. However, successful recanalization is associated with better results and increasing numbers of patients are surviving with antithrombotic therapy, thrombolysis and endovascular techniques.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mattle HP, Arnold M, Lindsberg PJ, et al. Basilar artery occlusion. Lancet Neurol. 2011;10:1002–14.

    Article  PubMed  Google Scholar 

  2. Voetsch B, DeWitt D, Pessin MS, et al. Basilar artery occlusive disease in the New England Medical Centre Posterior Circulation Registry. Arch Neurol. 2004;61:496–504.

    Article  PubMed  Google Scholar 

  3. Baird TA, Muir KW, Bone I. Basilar artery occlusion. Neurocrit Care. 2004;1:319–30.

    Article  PubMed  Google Scholar 

  4. Richardson PG. Basilar artery thrombosis. Emerg Med. 2001;13:367–72.

    Article  CAS  Google Scholar 

  5. Archer CR, Horenstein S. Basilar artery occlusion: clinical and radiographic correlation. Stroke. 1977;8:383–91.

    Article  CAS  PubMed  Google Scholar 

  6. Ferbert A, Bruckman H, Drunmen R. Clinical features of proven basilar artery occlusion. Stroke. 1990;21:1135–42.

    Article  CAS  PubMed  Google Scholar 

  7. Lindsberg PJ, Soinne L, Tatlisumak T, et al. Long-term outcome after intravenous thrombolysis of basilar artery occlusion. JAMA. 2004;292:1862–6.

    Article  CAS  PubMed  Google Scholar 

  8. Brandt T, von Kummer R, Muller-Kuppers M, et al. Thrombolytic therapy of acute basilar artery occlusion: variables affecting recanalization and outcome. Stroke. 1996;27:875–81.

    Article  CAS  PubMed  Google Scholar 

  9. Bergui M, Stura G, Daniele D, et al. Mechanical thrombolysis in ischaemic stroke attributable to basilar artery occlusion as first-line treatment. Stroke. 2006;37:145–50.

    Article  PubMed  Google Scholar 

  10. Wang H, Foster K, Wang D, et al. Successful intra-arterial basilar artery thrombolysis in a patient with bilateral vertebral artery occlusion; technical case report. Neurosurgery. 2005;57 suppl 4:e398.

    Article  PubMed  Google Scholar 

  11. Wijdicks EFM, Nichols DA, Thielen KR, et al. Intra-arterial thrombolysis in acute basilar artery thromboembolism: the initial Mayo Clinic experience. Mayo Clin Proc. 1997;72:1005–13.

    Article  CAS  PubMed  Google Scholar 

  12. Jung S, Mono ML, Fischer U, et al. Three-month and long-term outcomes and their predictors in acute basilar artery occlusion treated with intra-arterial thrombolysis. Stroke. 2011;42:1946–51.

    Article  PubMed  Google Scholar 

  13. Hacke W, Zeumer H, Ferbert A, et al. Intra-arterial thrombolytic therapy improves outcome in patients with acute vertebrobasilar occlusive disease. Stroke. 1988;19:1216–22.

    Article  CAS  PubMed  Google Scholar 

  14. Macleod MR, David SM, Mitchell PJ, et al. Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke. Cerebrovasc Dis. 2005;20(1):12–7.

    Article  CAS  PubMed  Google Scholar 

  15. Lin DDM, Gailloud P, Beauchamp NJ, et al. Combined stent placement and thrombolysis in acute vertebrobasilar ischaemic stroke. AJNR Am J Neuroradiol. 2003;24:1827–33.

    PubMed  Google Scholar 

  16. Chapot R, Houdart E, Rogopoulos A, et al. Thromboaspiration in the basilar artery: report of two cases. AJNR Am J Neuroradiol. 2002;23:282–4.

    PubMed  Google Scholar 

  17. Mordasini P, Brekenfeld C, Byrne JV, et al. Technical feasibility and application of mechanical thrombectomy with the Solitaire FR revascularization device in acute basilar artery occlusion. AJNR Am J Neuroradiol. 2013;34(1):159–63. doi:10.3174/ajnr.A3168.

    Article  CAS  PubMed  Google Scholar 

  18. Gress DR, Smith WS, Dowd CF, et al. Angioplasty for intracranial symptomatic vertebrobasilar ischaemia. Neurosurgery. 2002;51:23–9.

    Article  PubMed  Google Scholar 

  19. Schonewille WJ, Wijman CAC, Michel P, et al. on behalf of the BASICS Study Group. Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurol. 2009;8:724–30.

    Google Scholar 

  20. Mayer TE, Hamann GF, Brueckman HJ. Treatment of basilar artery embolism with a mechanical extraction device: necessity of flow reversal. Stroke. 2002;33:2232–5.

    Article  PubMed  Google Scholar 

  21. Zaidat OO, Tolbert M, Smith TP, et al. Primary endovascular therapy with clot retrieval and balloon angioplasty for acute basilar artery occlusion. Pediatr Neurosurg. 2005;41:323–7.

    Article  PubMed  Google Scholar 

  22. Yu W, Binder D, Foster-Barber A, et al. Endovascular embolectomy of acute basilar artery occlusion. Neurology. 2003;61:1421–3.

    Article  CAS  PubMed  Google Scholar 

  23. Arnold M, Nedeltchev K, Schroth G, et al. Clinical and radiological predictors of recanalization and outcome of 40 patients with acute basilar artery occlusion treated with intra-arterial thrombolysis. J Neurol Neurosurg Psychiatry. 2004;75:857–62.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Lindsberg PJ, Mattle HP. Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis. Stroke. 2006;37:922–8.

    Article  PubMed  Google Scholar 

  25. Gobin YP, Starkman S, Duckweiler GR, et al. MERCI I: a phase 1 study of mechanical embolus removal in cerebral ischaemia. Stroke. 2004;35:2848–54.

    Article  PubMed  Google Scholar 

  26. Leary MC, Saver JL, Gobin YP, et al. Beyond tissue plasminogen activator: mechanical intervention in acute stroke. Ann Emerg Med. 2003;41:838–46.

    Article  PubMed  Google Scholar 

  27. Kerber CW, Barr JD, Berger RM, et al. Snare retrieval of intracranial thrombus in patients with acute stroke. J Vasc Interv Radiol. 2002;13:1269–74.

    Article  PubMed  Google Scholar 

  28. Nedeltchev K, Remonda L, Do DD, et al. Acute stenting and thromboaspiration in basilar artery occlusions due to embolism from the dominating vertebral artery. Neuroradiology. 2004;46:686–91.

    Article  CAS  PubMed  Google Scholar 

  29. Cross III DT, Moran CJ, Akins PT, et al. Relationship between clot location and outcome after basilar artery thrombolysis. AJNR Am J Neuroradiol. 1997;18:1221–8.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fiona Kennedy MB, Bch, BAO, MRCP (UK) .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag London

About this chapter

Cite this chapter

Kennedy, F. (2015). Locked in or Break Out?. In: Gill, S., Brown, M., Robertson, F., Losseff, N. (eds) Stroke Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-6705-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-6705-1_4

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6704-4

  • Online ISBN: 978-1-4471-6705-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics