Skip to main content

Nonunion

  • Chapter
  • First Online:
Intramedullary Nailing

Abstract

The pathogenesis of bone healing disturbances is multifactorial, but especially related to impaired biology, inadequate stability, fracture gapping and infection. The key symptom is pain and discomfort at the site of nonunion while moving and weight-bearing the affected limb. Typical findings on conventional radiographs or CT support the diagnosis: missing progress of bone healing on serial images, loss of bridging trabecular bone crossing the fracture zone or hypertrophic bridging callus with persistent fracture gap. Breakage of implants is an additional, associated sign. Treatment principles consist of improvement of impaired biology and improvement of stability: restoration of axial alignment, stabilization of fracture fragments, reaming, intramedullary nailing with an increased nail diameter, compression of nonunion; and multiple interlocking. The authors prefer antegrade nailing with the patient in lateral position in femur diaphysis nonunion. Overreaming, exact positioning of the nail and interfragmentary compression are most important parts of the procedure. Exchange nailing is done as a closed procedure in hypertrophic nonunion of the tibia. For axis correction and in atrophic nonunion, the nonunion site is opened. Whenever an intact fibula blocks dynamization of the tibia, or compression across the tibial nonunion site, oblique fibula osteotomy and resection of a short segment is performed. Humerus nonunion after conservative treatment is treated with closed nailing, nonunion after nailing is treated with reaming, exchange nailing, compression and multiple interlocking. In metaphyseal nonunion, the use of an auxiliary plate; and in long oblique fractures, the use of cerclage wires is beneficial to secure fracture reduction during nail insertion and enhance stability of the nail-bone construct.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lu C, Miclau T, Hu D, Marcucio RS. Ischemia leads to delayed union during fracture healing: a mouse model. J Orthop Res. 2007;25:51–61.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Pihlajamäki HK, Salminen ST, Böstman OM. The treatment of nonunions following intramedullary nailing of femoral shaft fractures. J Orthop Trauma. 2002;16:394–402.

    Article  PubMed  Google Scholar 

  3. Malik MH, Harwood P, Diggle P, Khan SA. Factors affecting rates of infection and nonunion in intramedullary nailing. J Bone Joint Surg Br. 2004;86:556–60.

    CAS  PubMed  Google Scholar 

  4. Noumi T, Yokoyama K, Ohtsuka H, Nakamura K, Itoman M. Intramedullary nailing for open fractures of the femoral shaft: evaluation of contributing factors on deep infection and nonunion using multivariate analysis. Injury. 2005;36:1085–93.

    Article  PubMed  Google Scholar 

  5. Jain AK, Sinha S. Infected nonunion of the long bones. Clin Orthop Relat Res. 2005;431:57–65.

    Article  PubMed  Google Scholar 

  6. Motsitsi NS. Management of infected nonunion of long bones: the last decade (1996–2006). Injury. 2008;39:155–60.

    Article  CAS  PubMed  Google Scholar 

  7. Schmitz MA, Finnegan M, Natarajan R, Champine J. Effect of smoking on tibial shaft fracture healing. Clin Orthop Relat Res. 1999;365:184–200.

    Article  PubMed  Google Scholar 

  8. Lynch JR, Taitsman LA, Barei DP, Nork SE. Femoral nonunion: risk factors and treatment options. J Am Acad Orthop Surg. 2008;16:88–97.

    PubMed  Google Scholar 

  9. Krischak GD, Augat P, Blakytny R, Claes L, Kinzl L, Beck A. The non-steroidal anti-inflammatory drug diclofenac reduces appearance of osteoblasts in bone defect healing in rats. Arch Orthop Trauma Surg. 2007;127(6):453–8.

    Article  CAS  PubMed  Google Scholar 

  10. Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis: the influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000;82:655–8.

    Article  CAS  PubMed  Google Scholar 

  11. Watson JT, Moed BR. Ipsilateral femoral neck and shaft fractures: complications and their treatment. Clin Orthop Relat Res. 2002;399:78–86.

    Article  PubMed  Google Scholar 

  12. Bhattacharyya T, Bouchard KA, Phadke A, Meigs JB, Kassarjian A, Salamipour H. The accuracy of computed tomography for the diagnosis of tibial nonunion. J Bone Joint Surg Am. 2006;88:692–7.

    Article  PubMed  Google Scholar 

  13. Reichert IL, McCarthy ID, Hughes SP. The acute vascular response to intramedullary reaming: microsphere estimation of blood flow in the intact ovine tibia. J Bone Joint Surg Br. 1995;77:490–3.

    CAS  PubMed  Google Scholar 

  14. Furlong AJ, Giannoudis PV, DeBoer P, et al. Exchange nailing for femoral shaft aseptic non-union. Injury. 1999;30:245–9.

    Article  CAS  PubMed  Google Scholar 

  15. Carter DR, Blenman PR, Beaupre GS. Correlations between mechanical stress history and tissue differentiation in initial fracture healing. J Orthop Res. 1988;6:736–48.

    Article  CAS  PubMed  Google Scholar 

  16. Hierholzer C, Sama D, Toro JB, Peterson M, Helfet DL. Plate fixation of ununited humeral shaft fractures: effect of type of bone graft on healing. J Bone Joint Surg Am. 2006;88:1442–7.

    Article  PubMed  Google Scholar 

  17. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am. 2001;83(Suppl 1 (pt 2)):S151–8.

    PubMed  Google Scholar 

  18. Bostrom M, Lane JM, Tomin E, Browne M, Berberian W, Turek T, Smith J, Wozney J, Schildhauer T. Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model. Clin Orthop Relat Res. 1996;327:272–82.

    Article  PubMed  Google Scholar 

  19. Augat P, Penzkofer R, Nolte A, Maier M, Panzer S, v Oldenburg G, Pueschl K, Simon U, Bühren V. Interfragmentary movement in diaphyseal tibia fractures fixed with locked intramedullary nails. J Orthop Trauma. 2008;22:30–6.

    Article  PubMed  Google Scholar 

  20. Canadian Orthopaedic Trauma Society. Nonunion following intramedullary nailing of the femur with and without reaming. Results of a multicenter randomized clinical trial. J Bone Joint Surg Am. 2003;85:2093–6.

    Google Scholar 

  21. Shroeder JE, Mosheiff R, Khoury A, Liebergall M, Weil Y. The outcome of closed intramedullary exchange nailing with reamed insertion in the treatment of femoral shaft nonunion. J Orthop Trauma. 2009;23:653–7.

    Article  PubMed  Google Scholar 

  22. Webb LX, Winquist RA, Hansen ST. Intramedullary nailing and reaming for delayed union or nonunion of the femoral shaft. A report of 105 consecutive cases. Clin Orthop Relat Res. 1986;212:133–41.

    PubMed  Google Scholar 

  23. Wu CC. Exchange nailing for aseptic nonunion of femoral shaft: a retrospective cohort study for effect of reaming size. J Trauma. 2007;63:859–65.

    Article  PubMed  Google Scholar 

  24. Klein MP, Rahn BA, Frigg R, et al. Reaming versus non-reaming in medullary nailing: interference with cortical circulation of the canine tibia. Arch Orthop Trauma Surg. 1990;109:314–6.

    Article  CAS  PubMed  Google Scholar 

  25. Kuzyk PR, Li R, Zdero R, Davies JE, Schemitsch EH. The effect of intramedullary reaming on a diaphyseal bone defect of the tibia. J Trauma. 2011;70:1248–56.

    Article  PubMed  Google Scholar 

  26. Schemitsch E, Kowalski M, Swiontkowski M. Soft-tissue blood flow following reamed versus unreamed locked intramedullary nailing: a fractured sheep tibia model. Ann Plast Surg. 1996;36:70–5.

    Article  CAS  PubMed  Google Scholar 

  27. Hupel T, Aksenov S, Schemitsch E. Muscle perfusion after intramedullary nailing of the canine tibia. J Trauma. 1998;45(2):256–62.

    Article  CAS  PubMed  Google Scholar 

  28. Bakker AD, Kroeze RJ, Korstjens C, de Kleine RH, Frölke JP, Klein-Nulend J. Reaming debris as a novel source of autologous bone to enhance healing of bone defects. J Biomed Mater Res A. 2011;97:457–65.

    Article  PubMed  Google Scholar 

  29. Hupel T, Aksenov S, Schemitsch E. Cortical bone blood flow in loose and tight fitting locked unreamed intramedullary nailing: a canine segmental tibia fracture model. J Orthop Trauma. 1998;12:127–35.

    Article  CAS  PubMed  Google Scholar 

  30. Hupel T, Aksenov S, Schemitsch E. Effect of limited and standard reaming on cortical bone blood flow and early strength of union following segmental fracture. J Orthop Trauma. 1998;12:400–6.

    Article  CAS  PubMed  Google Scholar 

  31. Kempf I, Grosse A, Rigaut P. The treatment of noninfected pseudarthrosis of the femur and tibia with locked intramedullary nailing. Clin Orthop Relat Res. 1986;212:142–54.

    PubMed  Google Scholar 

  32. Banaszkiewicz PA, Sabboubeh A, McLeod I. Femoral exchange nailing for aseptic non-union: not the end to all problems. Injury. 2003;34:349–56.

    Article  PubMed  Google Scholar 

  33. Weresh MJ, Hakanson R, Stover MD, et al. Failure of exchange reamed intramedullary nails for ununited femoral shaft fractures. J Orthop Trauma. 2000;14:335–8.

    Article  CAS  PubMed  Google Scholar 

  34. Sims SH. Subtrochanteric femoral fractures. Orthop Clin North Am. 2002;33:113–26.

    Article  PubMed  Google Scholar 

  35. Hammer AJ. Nonunion of subcapital femoral neck fractures. J Orthop Trauma. 1992;6:73–7.

    CAS  PubMed  Google Scholar 

  36. Pauwels F. Biomechanics of the normal and diseased hip. (trans: Furlong RJ, Maquet P). Berlin: Springer; 1976.

    Google Scholar 

  37. Haidukewych GJ, Berry DJ. Nonunion of fractures of the subtrochanteric region of the femur. Clin Orthop Relat Res. 2004;419:185–8.

    Article  PubMed  Google Scholar 

  38. Jeon IH, Oh CW, Kim SJ, et al. Minimally invasive percutaneous plating of distal femoral fractures using the dynamic condylar screw. J Trauma. 2004;57:1048–52.

    Article  PubMed  Google Scholar 

  39. Hierholzer C, von Rüden C, Pötzel T, Woltmann A, Bühren V. Outcome analysis of retrograde nailing and less invasive stabilization system in distal femoral fractures: a retrospective analysis. Indian J Orthop. 2011;45(3):243–50.

    Article  PubMed Central  PubMed  Google Scholar 

  40. Pacheco RJ, Bradbury MD, Kasis AG, Saleh M. Management of nonunion in trauma. Trauma. 2004;6:225–47.

    Article  Google Scholar 

  41. McQueen MM, Christie J, Court-Brown CM. Acute compartment syndrome in tibial diaphyseal fractures. J Bone Joint Surg Br. 1996;78(1):95–8.

    CAS  PubMed  Google Scholar 

  42. Wu CC, Shih CH. Comparison of dynamic compression plating and reamed intramedullary nailing in the treatment of aseptic tibial shaft nonunions. Contemp Orthop. 1994;28(1):28–33.

    CAS  PubMed  Google Scholar 

  43. Wiss DA, Johnson DL, Miao M. Compression plating for non-union after failed external fixation of open tibial fractures. J Bone Joint Surg Am. 1992;74(9):1279–85.

    CAS  PubMed  Google Scholar 

  44. Marti RK, Verheyen CC, Besselaar PP. Humeral shaft nonunion: evaluation of uniform surgical repair in fifty-one patients. J Orthop Trauma. 2002;16:108–15.

    Article  CAS  PubMed  Google Scholar 

  45. Tetsworth K, Krome J, Paley D. Lengthening and deformity correction of the upper extremity by the Ilizarov technique. Orthop Clin North Am. 1991;22:689–713.

    CAS  PubMed  Google Scholar 

  46. Lin J, Hou SM, Hang YS. Treatment of humeral shaft delayed unions and nonunions with humeral locked nails. J Trauma. 2000;48:695–703.

    Article  CAS  PubMed  Google Scholar 

  47. Barker AT, Dixon RA, Sharrard WJ, Sutcliffe ML. Pulsed magnetic field therapy for tibial non-union: interim results of a double-blind trial. Lancet. 1984;1:994–6.

    Article  CAS  PubMed  Google Scholar 

  48. Sharrard WJ. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures. J Bone Joint Surg Br. 1990;72:347–55.

    CAS  PubMed  Google Scholar 

  49. Einhorn TA. Clinical applications of recombinant human BMPs: early experience and future development. J Bone Joint Surg Am. 2003;85 Suppl 3:82–8.

    PubMed  Google Scholar 

  50. Wu CC, Chen WJ. Treatment of femoral shaft aseptic nonunions: comparison between closed and open bone-grafting techniques. J Trauma. 1997;43:112–6.

    Article  CAS  PubMed  Google Scholar 

  51. Utvag SE, Grundnes O, Reikeras O. Graded exchange reaming and nailing of non-unions. Strength and mineralisation in rat femoral bone. Arch Orthop Trauma Surg. 1998;118:1–6.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christian Hierholzer MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag London

About this chapter

Cite this chapter

Hierholzer, C., Bühren, V. (2015). Nonunion. In: Rommens, P., Hessmann, M. (eds) Intramedullary Nailing. Springer, London. https://doi.org/10.1007/978-1-4471-6612-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-6612-2_25

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6611-5

  • Online ISBN: 978-1-4471-6612-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics