Langerhans Cell Histiocytosis

  • Ricardo K. Kalil


Langerhans cell histiocytosis comprises a set of conditions ranging from a localized form represented by a solitary lesion to a disseminated multiorgan involvement and having in common the microscopic findings of foci of proliferating Langerhans cells. Variants include eosinophilic granuloma (localized disease), Hand–Schuller–Christian disease (disseminated form), and Letterer–Siwe disease (disseminated and fatal form).


Langerhans Histiocytosis Eosinophilic granuloma Bone Tumor 

Recommended Reading

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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.Laboratory of Orthopaedic PathologyBuenos AiresArgentina
  2. 2.Department of PathologyA.C. Camargo Cancer CenterSão PauloBrazil

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