Langerhans Cell Histiocytosis

Abstract

Langerhans cell histiocytosis comprises a set of conditions ranging from a localized form represented by a solitary lesion to a disseminated multiorgan involvement and having in common the microscopic findings of foci of proliferating Langerhans cells. Variants include eosinophilic granuloma (localized disease), Hand–Schuller–Christian disease (disseminated form), and Letterer–Siwe disease (disseminated and fatal form).

Keywords

Langerhans Histiocytosis Eosinophilic granuloma Bone Tumor 

Recommended Reading

  1. Abla O, Egeler RM, Weitzman S. Langerhans cell histiocytosis: current concepts and treatments. Cancer Treat Rev. 2010;36(4):354–9.CrossRefPubMedGoogle Scholar
  2. Chu T, Jaffe R. The normal langerhans cell and the LCH cell. Br J Cancer Suppl. 1994;23:S4–10.PubMedCentralPubMedGoogle Scholar
  3. Hindman BW, Thomas RD, Young LW, Yu L. Langerhans cell histiocytosis: unusual skeletal manifestations observed in thirty-four cases. Skelet Radiol. 1998;27(4):177–81.CrossRefGoogle Scholar
  4. Kilpatrick SE, Wenger DE, Gilchrist GS, Shives TC, Wollan PC, Unni KK. Langerhans’ cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases. Cancer. 1995;76(12):2471–84.CrossRefPubMedGoogle Scholar
  5. Lichtenstein L. Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity. AMA Arch Pathol. 1953;56(1):84–102.PubMedGoogle Scholar
  6. Lichtenstein L. Histiocytosis X, (eosinophilic granuloma of bone, Letterer-Siwe disease, and Schueller-Christian disease). Further observations of pathological and clinical importance. J Bone Joint Surg Am. 1964;46:76–90.PubMedGoogle Scholar
  7. Lichtenstein L, Jaffe HL. Eosinophilic granuloma of bone: with report of a case. Am J Pathol. 1940;16(5):595–604.3.PubMedCentralPubMedGoogle Scholar
  8. Lieberman PH, Jones CR, Steinman RM, Erlandson RA, Smith J, Gee T, Huvos A, Garin-Chesa P, Filippa DA, Urmacher C, Gangi MD, Sperber M. Langerhans cell (eosinophilic) granulomatosis. A clinicopathologic study encompassing 50 years. Am J Surg Pathol. 1996;20(5):519–52.CrossRefPubMedGoogle Scholar
  9. Mistry M. Eosinophilic granuloma of bone; case record and short review of literature. Postgrad Med J. 1957;33(380):290–4.CrossRefPubMedCentralPubMedGoogle Scholar
  10. Price CH. Histiocytosis X: histology (review of Bristol bone tumour registry cases). Proc R Soc Med. 1971;64(4):336–8.PubMedCentralPubMedGoogle Scholar
  11. Stull MA, Kransdorf MJ, Devaney KO. Langerhans cell histiocytosis of bone. Radiographics. 1992;12(4):801–23.CrossRefPubMedGoogle Scholar
  12. Wester SM, Beabout JW, Unni KK, Dahlin DC. Langerhans’ cell granulomatosis (histiocytosis X) of bone in adults. Am J Surg Pathol. 1982;6(5):413–26.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.Laboratory of Orthopaedic PathologyBuenos AiresArgentina
  2. 2.Department of PathologyA.C. Camargo Cancer CenterSão PauloBrazil

Personalised recommendations