Neurofibroma of Bone


Neurofibroma (NF) is a benign neoplasm originated in nerve fascicles and containing Schwann cells, fibroblasts, mast cells, axons, and variable collagen matrix, exceedingly rare in the bone. NF originates in peripheral nerves at the periosteum, cortex, or vascular marrow. Most cases occur in the head and neck, especially the maxilla. Radiologically, neurofibroma is a radiolucent well-circumscribed lesion. Relationship to known nerve tracts may suggest the diagnosis. The tumor is not well circumscribed, and its short spindle cells have long wavy nuclei, with partial positivity for S100. Allelic loss of the NF1 gene region of 17q in Schwann cells is found. Wide resection is recommended to avoid recurrence.


Neurofibroma Neurofibromatosis Peripheral nerve Tumor Bone NF1 

Recommended Reading

  1. Fawcett KJ, Dahlin DC. Neurilemmoma of bone. Am J Clin Pathol. 1967;47(6):759–66.PubMedGoogle Scholar
  2. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. WHO classification of tumors of soft tissue and bone. Lyon: IARC; 2013. p. 174–6.Google Scholar
  3. Huang GS, Lee CH, Lee HS, Chang WC, Juan CJ, Chen CY. Solitary intraosseous neurofibroma of the tibia. Skelet Radiol. 2005;34(5):303–6. Epub 2004 Nov 13, PubMed PMID: 15838705.CrossRefGoogle Scholar
  4. Pontes HA, Pontes FS, Cruz e Silva BT, Fonseca FP, Carneiro Jr JT, Paiva HB, Pinto Ddos Jr S. Solitary neurofibroma of the temporal bone. J Craniofac Surg. 2010;21(6):1984–7. doi: 10.1097/SCS.0b013e3181f503be. PubMed PMID: 21119477.CrossRefPubMedGoogle Scholar
  5. Unni KK, Inwards C. Dahlin’s bone tumors. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010. p. 295.Google Scholar
  6. Yamaguchi R, Yoshida T, Nakazato Y, Yoshimoto Y. Solitary intraosseous neurofibroma of the frontal bone. Case report. Neurol Med Chir (Tokyo). 2010;50(8):683–6. PubMed PMID: 20805655.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.Laboratory of Orthopaedic PathologyBuenos AiresArgentina
  2. 2.Department of PathologyA.C. Camargo Cancer CenterSão PauloBrazil

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