Neurofibroma of Bone

  • Ricardo K. Kalil


Neurofibroma (NF) is a benign neoplasm originated in nerve fascicles and containing Schwann cells, fibroblasts, mast cells, axons, and variable collagen matrix, exceedingly rare in the bone. NF originates in peripheral nerves at the periosteum, cortex, or vascular marrow. Most cases occur in the head and neck, especially the maxilla. Radiologically, neurofibroma is a radiolucent well-circumscribed lesion. Relationship to known nerve tracts may suggest the diagnosis. The tumor is not well circumscribed, and its short spindle cells have long wavy nuclei, with partial positivity for S100. Allelic loss of the NF1 gene region of 17q in Schwann cells is found. Wide resection is recommended to avoid recurrence.


Neurofibroma Neurofibromatosis Peripheral nerve Tumor Bone NF1 

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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.Laboratory of Orthopaedic PathologyBuenos AiresArgentina
  2. 2.Department of PathologyA.C. Camargo Cancer CenterSão PauloBrazil

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