Abstract
The uterine cavity is lined by the endometrium. This lining is composed of two layers, the functional layer (adjacent to the uterine cavity) which is shed during menstruation and an underlying basal layer (adjacent to the myometrium) which is necessary for regenerating the functional layer. Thorough curettage and removal/partial removal of the basal layer often leads to a condition known as synechia, or Asherman’s syndrome (AS) or Fritsch syndrome, where there is intrauterine adhesion of the walls of the uterus, as a result of which the estrogen-sensitive areas are lost leading to a condition where patients experience secondary menstrual irregularities characterized by a decrease in flow and duration of bleeding (amenorrhea, hypomenorrhea, or oligomenorrhea).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Klein SM, Garcia C-R. Asherman’s syndrome: a critique and current review. Fertil Steril. 1973;24(9):722–35.
Valle RF, Sciarra JJ. Intrauterine adhesions: hystreoscopic diagnosis, classification, treatment and reproductive outcome. Am J Obstet. 1988;158(6Pt1):1459–70.
Buttram VC, Turati G. Uterine synechiae: variations in severity and some conditions which may be conducive to severe adhesions. Int J Fertil. 1977;22(2):98–103.
Krolikowski A, Janowski K, Larsen JV. Asherman syndrome caused by schistosomiasis. Obstet Gynecol. 1995;85(5Pt2):898–9.
Bukulmez O, Yarali H, Gurgan T. Total corporal synechiae due to tuberculosis carry a very poor prognosis following hysteroscopic synechialysis. Hum Reprod. 1999;14(8):1960–1.
Fernandez H, Al-Najjar F, Chauvenaud-Lambling A, et al. Fertility after treatment of Asherman’s syndrome stage 3 and 4. J Minim Invasive Gynecol. 2006;13(5):398–402.
Roge P, D’ercole C, Cravello L, Boubli L, Blanc B. Hysteroscopic management of uterine synechiae: a series of 102 observations. Eur J Obstet Gynecol Reprod Biol. 1996;65(2):189–93.
Capella-Allouc S, Morsad F, Rongieres-Bertrand C, et al. Hysteroscopic treatment of severe Asherman’s syndrome and subsequent fertility. Hum Reprod. 1999;14(5):1230–3.
Deaton JL, Maier D, Andreoli J. Spontaneous uterine rupture during pregnancy after treatment of Asherman’s syndrome. Am J Obstet Gynecol. 1989;160(5Pt1):1053–4.
Yu D, Wong YM, Cheong Y, Xia E, Li TC. Review Asherman syndrome – one century later. Fertil Steril. 2008;89(4):759–79.
Salamonsen LA. Review tissue injury and repair in the female human reproductive tract. Reproduction. 2003;125(3):301–11.
Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007;25:2082–6.
Gargett CE, Masuda H. Review adult stem cells in the endometrium. Mol Hum Reprod. 2010;16(11):818–34.
Gargett CE, Masuda H. Adult stem cells in the endometrium. Mol Hum Reprod. 2010;16(11):818–34.
Acknowledgment
The Department of Science and Technology, Government of West Bengal, supported the investigator with a research grant during his tenure at Bijoygarh State General Hospital from 1999 to 2006. The work started in Bijoygarh Government Hospital (1999–2006) and was followed up at Vidyasagore Government Hospital subsequently. The author gratefully acknowledges the support of the patients who volunteered for this research work. The guidance of Prof. K. L. Mukherjee of Biochemistry and Prof. M. K. Chhetri, former Director of Health Services, is acknowledged.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag London
About this chapter
Cite this chapter
Bhattacharya, N., Banerjee, S.K., Malakar, D. (2015). Uterine Synechia: A Preliminary Communication on an Attempted Treatment of the Condition with Intrauterine Instillation of Autologous Bone Marrow Mononuclear Cells. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-6542-2_25
Download citation
DOI: https://doi.org/10.1007/978-1-4471-6542-2_25
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-6541-5
Online ISBN: 978-1-4471-6542-2
eBook Packages: MedicineMedicine (R0)