Uterine Synechia: A Preliminary Communication on an Attempted Treatment of the Condition with Intrauterine Instillation of Autologous Bone Marrow Mononuclear Cells

  • Niranjan Bhattacharya
  • Sushanta Kumar Banerjee
  • Dhruba Malakar


The uterine cavity is lined by the endometrium. This lining is composed of two layers, the functional layer (adjacent to the uterine cavity) which is shed during menstruation and an underlying basal layer (adjacent to the myometrium) which is necessary for regenerating the functional layer. Thorough curettage and removal/partial removal of the basal layer often leads to a condition known as synechia, or Asherman’s syndrome (AS) or Fritsch syndrome, where there is intrauterine adhesion of the walls of the uterus, as a result of which the estrogen-sensitive areas are lost leading to a condition where patients experience secondary menstrual irregularities characterized by a decrease in flow and duration of bleeding (amenorrhea, hypomenorrhea, or oligomenorrhea).


Uterine Cavity Functional Layer Placenta Accreta Epithelial Progenitor Cell Intrauterine Adhesion 
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The Department of Science and Technology, Government of West Bengal, supported the investigator with a research grant during his tenure at Bijoygarh State General Hospital from 1999 to 2006. The work started in Bijoygarh Government Hospital (1999–2006) and was followed up at Vidyasagore Government Hospital subsequently. The author gratefully acknowledges the support of the patients who volunteered for this research work. The guidance of Prof. K. L. Mukherjee of Biochemistry and Prof. M. K. Chhetri, former Director of Health Services, is acknowledged.


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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  • Niranjan Bhattacharya
    • 1
  • Sushanta Kumar Banerjee
    • 2
  • Dhruba Malakar
    • 3
  1. 1.Regenerative Medicine and Transplant ScienceColcatta School of Tropical MedicineKolkataIndia
  2. 2.Health of Family WelfareSwasthya Bhavan, Govt. of West BengalKolkataIndia
  3. 3.Animal Biotechnology CentreNational Dairy Research InstituteKarnalIndia

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