Abstract
In early embryo development, the tooth tissues are originated from the neural crest anatomical site. Neural crest stem cells are considered embryonic-like stem cells, which are maintained under the control of Hox genes. Moreover, they are clonogenic cells and are able to differentiate into various cell types, such as odontoblasts, osteoblasts, chondrocytes, neurons, melanocytes, and the muscles. Following the migration of neural crest stem cells during fetal development, the oral epithelium- and cranial crest-derived mesenchymal cells arise, which next form the dental follicle and dental pulp.
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References
Almeida FM, Marques SA, Ramalho BD, Rodrigues RF, Cadilhe DV, Furtado DR, Kerkis I, Pereira LV, Rehen SK, Martinez AM. Human dental pulp cells: a new source of cell therapy in a mouse model of compressive spinal cord injury. J Neurotrauma. 2011;28(9):1939–49.
Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9(5):641–50.
de Mendonca CA, Bueno DF, Martins MT, Kerkis I, Kerkis A, et al. Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells. J Craniofac Surg. 2008;19:204–10.
Dupin E, Calloni G, Real C, Gonçalves-Trentin A, Le Douarin NM. Neural crest progenitors and stem cells. C R Biol. 2007;330(6–7):521–9.
Fonseca SAS, Abdelmassih S, de Mello Cintra Lavagnolli T, Serafim RC, Clemente Santos EJ, et al. Human immature dental pulp stem cells’ contribution to developing mouse embryos: production of human/mouse preterm chimaeras. Cell Prolif. 2009;42:132–40.
Friedenstein AJ, Deriglasova UF, Kulagina NN, Panasuk AF, Rudakowa SF, Luriá EA, Ruadkow IA. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol. 1974;2(2):83–92.
Giordano G, La Monaca G, Annibali S, Cicconetti A, Ottolenghi L. Stem cells from oral niches: a review. Ann Stomatol. 2011;2(1–2):3–8.
Gomes JA, Geraldes Monteiro B, Melo GB, Smith RL, Pereira C, da Silva M, et al. Corneal reconstruction with tissue-engineered cell sheets composed of human immature dental pulp stem cells. Invest Ophthalmol Vis Sci. 2010;51:1408–14.
Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human DP stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000;97:13625–30.
Kerkis I, Ambrosio CE, Kerkis A, Martins DS, Zucconi E, et al. Early transplantation of human immature DP stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: local or systemic? J Transl Med. 2008;6:35.
Kerkis I, Caplan AI. Stem cells in dental pulp of deciduous teeth. Tissue Eng Part B. 2012;18(2):129–38.
Kerkis I, Kerkis A, Dozortsev D, Stukart-Parsons GC, Gomes Massironi SM, et al. Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs. 2006;184:105–16.
Le Douarin NM, Brito JM, Creuzet S. Role of the neural crest in face and brain development. Brain Res Rev. 2007;55(2):237–47.
Le Douarin NM, Calloni GW, Dupin E. The stem cells of the neural crest. Cell Cycle. 2008;7:1013–9.
Le Douarin NM, Creuzet S, Dupin E. Neural crest cell plasticity and its limits. Development. 2004;131:4637–50.
Le Douarin NM, Dupin E. Multipotentiality of the neural crest. Curr Opin Genet Dev. 2003;13:529–36.
Le Douarin NM, Dupin E. The neural crest in vertebrate evolution. Curr Opin Genet Dev. 2012;22(4):381–9.
Lizier NF, Kerkis A, Gomes CM, Hebling J, Oliveira CF, Caplan AI, Kerkis I. Scaling-up of dental pulp stem cells isolated from multiple niches. PLoS One. 2012;7(6):e39885. Epub 2012 Jun 29.
Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003;100:5807–12.
Pierdomenico L, Bonsi L, Calvitti M, Rondelli D, Arpinati M, Chirumbolo G, Becchetti E, Marchionni C, Alviano F, Fossati V, Staffolani N, Franchina M, Grossi A, Bagnara GP. Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation. 2005;80(6):836–42.
Shi S, Gronthos S. Perivascular niche of post natal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res. 2003;189:696–704.
Singer NG, Caplan AI. Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011;6:457–78. Review.
Wada N, Menicanin D, Shi S, Bartold PM, Gronthos S. Immunomodulatory properties of human periodontal ligament stem cells. J Cell Physiol. 2009;219(3):667–76.
Zhang Y, Bellows CF, Kolonin MG. Adipose tissue-derived progenitor cells and cancer. World J Stem Cells. 2010;2(5):103–13.
Acknowledgments
The authors thank Dr. Arnold Caplan from Case Western University for his contribution in the research.
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Kerkis, I., Kerkis, A., Lizier, N.F., Wenceslau, C.V. (2015). Dental Stem Cells: Risk and Responsibilities. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-6542-2_16
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DOI: https://doi.org/10.1007/978-1-4471-6542-2_16
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