Patch Testing in Drug Eruptions

  • Esen Özkaya
  • Kurtuluş Didem Yazganoğlu


Patch testing is a method carried out by dermatologists to evaluate type IV hypersensitivity reactions. It is the gold standard in the diagnosis of allergic contact dermatitis. Based on the recent knowledge on the involvement of different subtypes of type IV hypersensitivity reactions in the immunopathogenesis of drug eruptions (Table  1.1), patch testing is also of particular value in determining the responsible drug in certain drug eruptions such as eczematous eruption, maculopapular/morbilliform eruption, fixed drug eruption, photoallergic drug eruption, drug-induced Baboon syndrome (BS)/symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), and acute generalized exanthematous pustulosis (AGEP) as a first-step diagnostic method. It is also helpful in identifying the possible cross-reactive drugs and safe alternatives. Photopatch testing should be performed if there is suspicion of photoallergic drug eruptions.


Drug eruption Patch test Photopatch test Cardiovascular drugs Commercial drug Patch testing in loco Serial dilution Tape stripping Prick/scratch/intradermal tests with late readings Clinical relevance 


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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Esen Özkaya
    • 1
  • Kurtuluş Didem Yazganoğlu
    • 1
  1. 1.Department of Dermatology and VenereologyIstanbul University Istanbul Medical FacultyIstanbulTurkey

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