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End-of-Life Care in Hospitalized Patients with Cardiovascular and Cerebrovascular Disease

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End-of-Life Care in Cardiovascular Disease

Abstract

We sought to review and increase understanding of the last days of life of patients hospitalized with advanced heart failure and acute stroke, which are the paradigms of end-of-life care of patients with cardiovascular and cerebrovascular disease, in order to improve treatment and clinical decision-making. These patients constitute an increasing health care problem, entailing both high morbidity and mortality. In-hospital death rates for cardiovascular illnesses have decreased over several decades, although they vary by geographic region and health care resources. Cardiovascular disease is the primary cause of death world-wide. While in-hospital death from coronary artery and valvular heart disease is less common now than it was several decades ago, reduction in hospital and short-term post-hospital mortality are major quality initiatives. Comprehensive clinical evaluation is essential in order to identify factors that may influence prognosis (e.g., comorbid conditions, functional status, and frailty) so that best and early care programs can be administered. Palliative care is known to be relatively undeveloped in these groups of patients, and should be implemented and be part of the multidisciplinary approach. The aim in patients likely to die is to improve symptoms and quality of life, while avoiding the use of aggressive therapies that are known to consume health-care resources without providing significant benefit. Physicians should not only use palliative measures when the patient is close to death, but throughout care. Dying patients with cardiovascular or cerebrovascular disease have the right to be involved in the decision-making process. Consequently, they or a designated surrogate should be fully informed about their medical condition, eventual interventions and prognosis. This is essential so that the can express their opinion and wishes, including place of death and psycho-spiritual care.

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References

  1. Senni M, Tribouilloy CM, Rodeheffer RJ, Jacobsen SJ, Evans JM, Bailey KR, Redfield MM. Congestive heart failure in the community: trends in incidence and survival in a 10-year period. Arch Intern Med. 1999;159:29–34.

    PubMed  CAS  Google Scholar 

  2. Hobbs FD, Kenkre JE, Roalfe AK, Davis RC, Hare R, Davies MK. Impact of heart failure and left ventricular systolic dysfunction on quality of life: a cross-sectional study comparing common chronic cardiac and medical disorders and a representative adult population. Eur Heart J. 2002;23:1867–76.

    PubMed  CAS  Google Scholar 

  3. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2012;14(8):803–69.

    PubMed  CAS  Google Scholar 

  4. Yancy CW, Jessup M, Bozkurt B, Butler J, et al. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62(16):1495–539.

    Google Scholar 

  5. Nieminen MS, Brutsaert D, Dickstein K, Drexler H, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27:2725–36.

    PubMed  Google Scholar 

  6. Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, et al. Guias europeas de practica clinica para el diagnostico y tratamiento de la insuficiencia cardiaca aguda y cronica. Grupo de Trabajo de la ESC para el diagnostico y tratamiento de la insuficiencia cardiaca aguda y cronica (2008). Desarrollada en colaboracion con la Heart Failure Association (HFA) de la ESC y aprobada por la European Society of Intensive Care Medicine (ESICM). Rev Esp Cardiol. 2008;61:1329.e1–70.

    Google Scholar 

  7. Peterson ED, Coombs LP, DeLong ER, et al. Procedural volume as a marker of quality for CABG surgery. JAMA. 2004;291:195.

    PubMed  CAS  Google Scholar 

  8. Sority A, Ahmed A, Starr SR, et al. Off-hours presentation and outcomes in patients with acute myocardial infarction: systemic review and meta-analysis. BMJ. 2014;348:1–16.

    Google Scholar 

  9. Martinez-Selles M, Hortal J, Barrio JM, Ruiz M, Bueno H. Treatment and outcomes of severe cardiac disease with surgical indication in very old patients. Int J Cardiol. 2007;119(1):15–20.

    PubMed  Google Scholar 

  10. Fonarow GC, Saver JL, Smith EE, Broderick JP, et al. Relationship of national institutes of health stroke scale to 30-day mortality in medicare beneficiaries with acute ischemic stroke. J Am Heart Assoc. 2012;1(1):42–50.

    PubMed  PubMed Central  Google Scholar 

  11. Koennecke HC, Beltz W, Berfelde D, et al. Factors influencing in-hospital mortality and morbidity in patients treated on a stroke unit. Neurology. 2011;77(10):965–72.

    PubMed  Google Scholar 

  12. The Dartmouth Atlas of Health Care. Accessed at: http://www.dartmouthatlas.org/data/bar.aspx?ind=84&tf=10&ch=9,35&loc=&loct=3&fmt=109 on 04/01/14.

  13. Cram P, Rosenthal GE, Vaughan-Sarrazin MS. Cardiac revascularization in specialty and general hospitals. N Engl J Med. 2005;352(14):1454.

    PubMed  CAS  Google Scholar 

  14. Baskett R, Buth K, Ghali W, et al. Outcomes in octogenarians undergoing coronary artery bypass grafting. CMAJ. 2005;172:1183.

    PubMed  PubMed Central  Google Scholar 

  15. Hauptman PJ, Goodlin SJ, Lopatin M, Costanzo MR, Fonarow GC, Yancy CW. Characteristics of patients hospitalized with acute decompensated heart failure who are referred for hospice care. Arch Intern Med. 2007;167:1990–7.

    PubMed  Google Scholar 

  16. Haga K, Murray S, Reid J, et al. Identifying community based chronic heart failure patients in the last year of life: a comparison of the Gold Standards Framework Prognostic Indicator Guide and the Seattle Heart Failure Model. Heart. 2012;98:579–83.

    PubMed  Google Scholar 

  17. Smith CR, Leon MB, Mack MJ, Miller DC, PARTNER Trial Investigators, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011;364(23):2187–98.

    PubMed  CAS  Google Scholar 

  18. Smith EE, Shobha N, Dai D, Olson DM, Reeves MJ, Saver JL, Hernandez AF, Peterson ED, Fonarow GC, Schwamm LH. A risk score for in-hospital death in patients admitted with ischemic or hemorrhagic stroke. J Am Heart Assoc. 2013;2(1):e005207.

    PubMed  PubMed Central  Google Scholar 

  19. Goodlin SJ. Palliative care in congestive heart failure. J Am Coll Cardiol. 2009;54:386–96.

    PubMed  Google Scholar 

  20. Lunney JR, Lynn J, Hogan C. Profiles of older medicare decedents. J Am Geriatr Soc. 2002;50:1108–12.

    PubMed  Google Scholar 

  21. Martinez-Selles M, Garcia Robles JA, Munoz R, Serrano JA, Frades E, Dominguez Munoa M, et al. Pharmacological treatment in patients with heart failure: patients knowledge and occurrence of polypharmacy, alternative medicine and immunizations. Eur J Heart Fail. 2004;6:219–26.

    PubMed  Google Scholar 

  22. Banegas JR, Rodriguez-Artalejo F. Insuficiencia cardiaca e instrumentos para medir la calidad de vida. Rev Esp Cardiol. 2008;61:233–5.

    Google Scholar 

  23. Goodlin SJ, Hauptman PJ, Arnold R, Grady K, et al. Consensus statement: palliative and supportive care in advanced heart failure. J Card Fail. 2004;10:200–9.

    PubMed  Google Scholar 

  24. Morrison RS, Meier DE. Clinical practice. Palliative care. N Engl J Med. 2004;350:2582–90.

    PubMed  CAS  Google Scholar 

  25. Formiga F, López-Soto A, Navarro M, Riera-Mestre A, Bosch X, Pujol R. Hospital deaths of people aged 90 and over: end-of-life palliative care management. Gerontology. 2008;54:148–52.

    PubMed  Google Scholar 

  26. Formiga F, Chivite D, Ortega C, Casas S, Ramo’n JM, Pujol R. End-of-life preferences in elderly patients admitted for heart failure. QJM. 2004;97:803–8.

    PubMed  CAS  Google Scholar 

  27. World Health Organization. WHO definition of palliative care. Geneva: World Health Organization; 2009. http://www.who.int/cancer/palliative/en/.

  28. Hauptman PJ, Havranek EP. Integrating palliative care into heart failure care. Arch Intern Med. 2005;165:374–8.

    PubMed  Google Scholar 

  29. Goodlin SJ. Palliative care for end-stage heart failure. Curr Heart Fail Rep. 2005;2:155–60.

    PubMed  Google Scholar 

  30. Martínez-Selles M, Vidan MT, López-Palop R, Rexach L, Sánchez E, Datino T, et al. End-stage heart disease in the elderly. Rev Esp Cardiol. 2009;62:409–21.

    Google Scholar 

  31. Rexach L. Cuidados paliativos en insuficiencia cardiaca. Medicina Paliativa. 2010;17(5):286–300.

    Google Scholar 

  32. Murray SA, Worth A, Boyd K, Kendall M, Hockley J, Pratt R, Denvir M, Arundel D. Patients’, carers’ and professionals’ experiences of diagnosis, treatment and end-of-life care in heart failure: a prospective, qualitative interview study. London: Department of Health/British Heart Foundation Heart Failure Research Initiative. Final report; 2007.

    Google Scholar 

  33. Murray SA, Sheikh A. Palliative care beyond cancer: care for all at the end of life. Br Med J. 2008;336:958–9.

    Google Scholar 

  34. Jaarsma T, Beattie JM, Ryder M, Rutten FH, Advanced Heart Failure Study Group of the HFA of the ESC, et al. Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2009;11:433–43.

    PubMed  Google Scholar 

  35. Jauch EC, Saver JL, Adams Jr HP, Bruno A, American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Peripheral Vascular Disease; Council on Clinical Cardiology, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870–947. doi:10.1161/STR.0b013e318284056a. Epub 2013 Jan 31.

    PubMed  Google Scholar 

  36. Morgenstern LB, Hemphill 3rd JC, Anderson C, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2010;41:2108–29.

    PubMed  Google Scholar 

  37. Creutzfeldt CJ, Holloway RG, Walker M. Symptomatic and palliative care for stroke survivors. J Gen Intern Med. 2012;27(7):853–60.

    PubMed  PubMed Central  Google Scholar 

  38. Langhorne P, Coupar F, Pollock A. Motor recovery after stroke: a systematic review. Lancet Neurol. 2009;8:741–54.

    PubMed  Google Scholar 

  39. Langhorne P, Bernhardt J, Kwakkel G. Stroke rehabilitation. Lancet. 2011;377:1693–702.

    PubMed  Google Scholar 

  40. Duncan PW, Zorowitz R, Bates B, et al. Management of adult stroke rehabilitation care: a clinical practice guideline. Stroke. 2005;36:e100–43.

    PubMed  Google Scholar 

  41. Cowey E. End of life care for patients following acute stroke. Nurs Stand. 2012;26(27):42–6.

    PubMed  Google Scholar 

  42. Wee B, Adams A, Eva G. Palliative and end-of-life care for people with stroke. Curr Opin Support Palliat Care. 2010;4(4):229–32.

    PubMed  Google Scholar 

  43. Aaronson KD, Schwartz JS, Chen TM, Wong KL, Goin JE, Mancini DM. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation. 1997;95:2660–7.

    PubMed  CAS  Google Scholar 

  44. Pocock SJ, Wang D, Pfeffer MA, Yusuf S, McMurray JJ, Swedberg KB, et al. Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J. 2006;27:65–75.

    PubMed  Google Scholar 

  45. Felker GM, Hasselblad V, Hernandez AF, O’Connor CM. Biomarkerguided therapy in chronic heart failure: a meta-analysis of randomized controlled trials. Am Heart J. 2009;158:422–30.

    PubMed  CAS  Google Scholar 

  46. Fischer S, Gozansky WS, Sauaia A, Min SJ, Kutner JS, Kramer A. A practical tool to identify patients who may benefit from a palliative approach: the CARING Criteria. J Pain Symptom Manage. 2006;31:285–92.

    PubMed  Google Scholar 

  47. Fox E, Landrum-McNiff K, Zhong Z, Dawson NV, Wu AW, Lynn J, SUPPORT Investigators. Evaluation of prognostic criteria for determining Hospice Eligibility in patients with advanced lung, heart or liver disease. JAMA. 1999;282:1638–45.

    PubMed  CAS  Google Scholar 

  48. Casarett DJ, Quill TE. “I’m not ready for hospice”: strategies for timely and effective hospice discussions. Ann Intern Med. 2007;146:443–9.

    PubMed  Google Scholar 

  49. Huynh BC, Rovner A, Rich MW. Identification of older patients with heart failure who may be candidates for hospice care: development of a simple four-item risk score. J Am Geriatr Soc. 2008;56:1111–5.

    PubMed  Google Scholar 

  50. Brophy JM, Dagenais GR, McSherry F, Williford W, Yusuf S. A multivariate model for predicting mortality in patients with heart failure and systolic dysfunction. Am J Med. 2004;116:300–4.

    PubMed  Google Scholar 

  51. Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB, et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation. 2006;113:1424–33.

    PubMed  Google Scholar 

  52. Lee DS, Austin PC, Rouleau JL, Liu PP, Naimark D, Tu JV. Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model. JAMA. 2003;290:2581–7.

    PubMed  CAS  Google Scholar 

  53. Heiat A, Gross CP, Krumholz HM. Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med. 2002;162:1682–8.

    PubMed  Google Scholar 

  54. Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, van den Bos GA. Causes and consequences of comorbidity: a review. J Clin Epidemiol. 2001;54:661–74.

    PubMed  CAS  Google Scholar 

  55. Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009;103:1616–21.

    PubMed  Google Scholar 

  56. Lupon J, Gonzalez B, Santaeugenia S, Altimir S, Urrutia A, Mas D, et al. Prognostic implication of frailty and depressive symptoms in an outpatient population with heart failure. Rev Esp Cardiol. 2008;61:835–42.

    Google Scholar 

  57. Komajda M, Hanon O, Hochadel M, Lopez-Sendon JL, et al. Contemporary management of octogenarians hospitalized for heart failure in Europe: Euro Heart Failure Survey II. Eur Heart J. 2009;30:478–86.

    PubMed  Google Scholar 

  58. Pocock SJ, Ariti CA, McMurray JJ, Maggioni A, Meta-Analysis Global Group in Chronic Heart Failure, et al. Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies. Eur Heart J. 2013;34(19):1404–13.

    PubMed  Google Scholar 

  59. Heidenreich PA, Spertus JA, Jones PG, Weintraub WS, Rumsfeld JS, Rathore SS, et al. Health status identifies heart failure outpatients at risk for hospitalization or death. J Am Coll Cardiol. 2006;47:752–6.

    PubMed  Google Scholar 

  60. Subramanian U, Eckert G, Yeung A, Tierney WM. A single health status question had important prognostic value among outpatients with chronic heart failure. J Clin Epidemiol. 2007;60:803–11.

    PubMed  Google Scholar 

  61. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Cardiovascular Health Study Collaborative Research Group, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56.

    PubMed  CAS  Google Scholar 

  62. Lunney JR, Lynn J, Foley DJ, Lipson S, Guralnik JM. Patterns of functional decline at the end of life. JAMA. 2003;28:2387–92.

    Google Scholar 

  63. Formiga F, Chivite D, Casas S, Manito N, Pujol R. Valoracion funcional en pacientes ancianos ingresados por insuficiencia cardiaca. Rev Esp Cardiol. 2006;59:740–2.

    Google Scholar 

  64. Inouye S, Peduzzi PN, Robinson JT, Hughes JS, Howitz RI, Concato J. Importance of functional measures in predicting mortality among older hospitalised patients. JAMA. 1998;279:1187–93.

    PubMed  CAS  Google Scholar 

  65. Brunner-La Rocca HP, Rickenbacher P, Muzzarelli S, Schindler R, TIME-CHF Investigators, et al. End-of-life preferences of elderly patients with chronic heart failure. Eur Heart J. 2012;33(6):752–9.

    PubMed  Google Scholar 

  66. Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48:1527–37.

    PubMed  Google Scholar 

  67. Chan W, Coutts SB, Hanly P. Sleep apnea in patients with transient ischemic attack and minor stroke: opportunity for risk reduction of recurrent stroke? Stroke. 2010;41:2973–5.

    PubMed  Google Scholar 

  68. Hackett ML, Anderson CS, House A, Xia J. Interventions for treating depression after stroke. Cochrane Database Syst Rev. 2008;(4):CD003437.

    Google Scholar 

  69. Saposnik G, Cote R, Rochon PA, Mamdani M, Liu Y, Raptis S, Kapral MK, Black SE, Registry of the Canadian Stroke Network; Stroke Outcome Research Canada (SORCan) Working Group. Care and outcomes in patients with ischemic stroke with and without preexisting dementia. Neurology. 2011;77(18):1664–73.

    PubMed  CAS  Google Scholar 

  70. Bernat JL. Do-not-resuscitate orders, quality of care, and outcomes in veterans with acute ischemic stroke. Neurology. 2013;81(2):199.

    PubMed  Google Scholar 

  71. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–37.

    PubMed  CAS  Google Scholar 

  72. Reddy VY, Reynolds MR, Neuzil P, Richardson AW, Taborsky M, Jongnarangsin K, et al. Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med. 2007;357:2657–65.

    PubMed  CAS  PubMed Central  Google Scholar 

  73. Ebrahim S. Do not resuscitate decisions: flogging dead horses or a dignified death? Resuscitation should not be withheld from elderly people without discussion. BMJ. 2000;320:1155–6.

    PubMed  CAS  PubMed Central  Google Scholar 

  74. Frank C, Heyland DK, Chen B, Farquhar D, Myers K, Iwaasa K. Determining resuscitation preferences of elderly inpatients: a review of the literature. CMAJ. 2003;169:795–9.

    PubMed  PubMed Central  Google Scholar 

  75. Goodlin SJ, Zhong Z, Lynn J, Teno JM, Fago JP, Desbiens N, et al. Factors associated with use of cardiopulmonary resuscitation in seriously ill hospitalized adults. JAMA. 1999;282:2333–9.

    PubMed  CAS  Google Scholar 

  76. Krumholz HM, Phillips RS, Hamel MB, Teno JM, et al. Resuscitation preferences among patients with severe congestive heart failure: results from the SUPPORT project. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Circulation. 1998;98(7):648–55.

    PubMed  CAS  Google Scholar 

  77. The SUPPORT Principal Investigators. A controlled trial to improve care for seriously ill hospitalized patients. JAMA. 1995;274:1591–8.

    Google Scholar 

  78. Martínez-Sellés M, Gallego L, Ruiz J, Fernández AF. Do-not-resuscitate orders and palliative care in patients who die in cardiology departments. What can be improved? Rev Esp Cardiol. 2010;63(2):233–7.

    Google Scholar 

  79. Payne S, Burton C, Addington-Hall J, Jones A. End-of-life issues in acute stroke care: a qualitative study of the experiences and preferences of patients and families. Palliat Med. 2010;24(2):146–53.

    PubMed  Google Scholar 

  80. Bestué Cardiel M, Ara JR, Martín Martínez J. Do not resuscitate orders in patients with acute stroke. What circumstances decide their use? Med Clin (Barc). 2002;118(5):170–3.

    Google Scholar 

  81. Loertscher L, Reed DA, Bannon MP, Mueller PS. Cardiopulmonary resuscitation and do-not-resuscitate orders: a guide for clinicians. Am J Med. 2010;123(1):4–9.

    PubMed  Google Scholar 

  82. Datino T, Rexach L, Vidán MT, Alonso A, Gándara A, Ruiz-García J, Fontecha B, Martínez-Sellés M. Guidelines on the management of implantable cardioverter defibrillators at the end of life. Rev Clin Esp. 2014;214:31–7.

    PubMed  CAS  Google Scholar 

  83. Hauptman PJ. Palliation in heart failure: when less and more are more. Am J Hosp Palliat Care. 2006;23:150–2.

    PubMed  Google Scholar 

  84. Gibbs JS, McCoy AS, Gibbs LM, Rogers AE, Addington-Hall JM. Living with and dying from heart failure: the role of palliative care. Heart. 2002;88 Suppl 2:ii36–9.

    PubMed  PubMed Central  Google Scholar 

  85. Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A, Bui C. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ. 2003;327:523–8.

    PubMed  CAS  PubMed Central  Google Scholar 

  86. Formiga F, Olmedo C, Lopez SA, Pujol R. Dying in hospital of severe dementia: palliative decision-making analysis. Aging Clin Exp Res. 2004;16(5):420–1.

    PubMed  Google Scholar 

  87. Roig E, Perez-Villa F, Cuppoletti A, Castillo M, Hernandez N, Morales M, et al. Programa de atencion especializada en la insuficiencia cardiaca terminal. Experiencia piloto de una unidad de insuficiencia cardiaca. Rev Esp Cardiol. 2006;59:109–16.

    Google Scholar 

  88. Lynn J, Teno JM, Phillips RS, Wu AW, Desbiens N, Harrold J, Claessens MT, Wenger N, Kreling B, Connors Jr AF. Perceptions by family members of the dying experience of older and seriously ill patients. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Ann Intern Med. 1997;126:97–106.

    PubMed  CAS  Google Scholar 

  89. Willems DL, Hak A, Visser F, Van der Wal G. Thoughts of patients with advanced heart failure on dying. Palliat Med. 2004;18:564–72.

    PubMed  CAS  Google Scholar 

  90. Han B, Haley WE. Family caregiving for patients with stroke. Review and analysis. Stroke. 1999;30:1478–85.

    PubMed  CAS  Google Scholar 

  91. Van den Heuvel ET, de Witte LP, Schure LM, Sanderman R, Meyboomde Jong B. Risk factors for burn-out in caregivers of stroke patients, and possibilities for intervention. Clin Rehabil. 2001;15:669–77.

    PubMed  Google Scholar 

  92. Kalra L, Evans A, Perez I, et al. Training carers of stroke patients: randomised controlled trial. BMJ. 2004;328:1099.

    PubMed  PubMed Central  Google Scholar 

  93. Blinderman CD, Homel P, Billings JA, Portenoy RK, Tennstedt SL. Symptom distress and quality of life in patients with advanced congestive heart failure. J Pain Symptom Manage. 2008;35:594–603.

    PubMed  PubMed Central  Google Scholar 

  94. Zambroski CH, Moser DK, Roser LP, Heo S, Chung ML. Patients with heart failure who die in hospice. Am Heart J. 2005;149:558–64.

    PubMed  Google Scholar 

  95. Chang VT, Hwang SS, Feuerman M. Validation of the Edmonton Symptom Assessment Scale. Cancer. 2000;88:2164–71.

    PubMed  CAS  Google Scholar 

  96. Kehayia E, Korner-Bitensky N, Singer F, et al. Differences in pain medication use in stroke patients with aphasia and without aphasia. Stroke. 1997;28:1867–70.

    PubMed  CAS  Google Scholar 

  97. Levenson JW, McCarthy EP, Lynn J, Davis RB, Phillips RS. The last six months of life for patients with congestive heart failure. J Am Geriatr Soc. 2000;48:S101–9.

    PubMed  CAS  Google Scholar 

  98. Williams SG, Wright DJ, Marshall P, Reese A, Tzeng BH, Coats AJ, et al. Safety and potential benefits of low dose diamorphine during exercise in patients with chronic heart failure. Heart. 2003;89:1085–6.

    PubMed  CAS  PubMed Central  Google Scholar 

  99. Appelros P. Prevalence and predictors of pain and fatigue after stroke: a population-based study. Int J Rehabil Res. 2006;29:329–33.

    PubMed  Google Scholar 

  100. Mead GE, Graham C, Dorman P, Bruins SK, Lewis SC, Dennis MS, Sandercock PA, UK Collaborators of IST. Fatigue after stroke: baseline predictors and influence on survival Analysis of data from UK patients recruited in the International Stroke Trial. PLoS One. 2011;6:e16988.

    PubMed  CAS  PubMed Central  Google Scholar 

  101. McGeough E, Pollock A, Smith LN, et al. Interventions for post-stroke fatigue. Cochrane Database Syst Rev. 2009;(3):CD007030.

    Google Scholar 

  102. Pantilat SZ, Steimle AE. Palliative care for patients with heart failure. JAMA. 2004;291:2476–82.

    PubMed  CAS  Google Scholar 

  103. Jönsson AC, Lindgren I, Hallström B, Norrving B, Lindgren A. Prevalence and intensity of pain after stroke: a population based study focusing on patients’ perspectives. J Neurol Neurosurg Psychiatry. 2006;77:590–5.

    PubMed  PubMed Central  Google Scholar 

  104. Klit H, Finnerup NB, Jensen TS. Central post-stroke pain: clinical characteristics, pathophysiology, and management. Lancet Neurol. 2009;8:857–68.

    PubMed  Google Scholar 

  105. Leijon G, Boivie J. Central post-stroke pain—a controlled trial of amitriptyline and carbamazepine. Pain. 1989;36:27–36.

    PubMed  CAS  Google Scholar 

  106. Vestergaard K, Andersen G, Gottrup H, Kristensen BT, Jensen TS. Lamotrigine for central poststroke pain: a randomized controlled trial. Neurology. 2001;56:184–90.

    PubMed  CAS  Google Scholar 

  107. Serpell MG, Neuropathic Pain Study Group. Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial. Pain. 2002;99:557–66.

    PubMed  CAS  Google Scholar 

  108. Frese A, Husstedt IW, Ringelstein EB, Evers S. Pharmacologic treatment of central post-stroke pain. Clin J Pain. 2006;22:252–60.

    PubMed  CAS  Google Scholar 

  109. Pelle AJ, Gidron YY, Szabo BM, Denollet J. Psychological predictors of prognosis in chronic heart failure. J Card Fail. 2008;14:341–50.

    PubMed  Google Scholar 

  110. Puchalski C, Ferrell B, Virani R, et al. Improving the quality of spiritual care as a dimension of palliative care: the report of the Consensus Conference. J Palliat Med. 2009;12:885–904.

    PubMed  Google Scholar 

  111. Steinhauser KE, Christakis NA, Clipp EC, McNeilly M, McIntyre L, Tulsky JA. Factors considered important at the end of life by patients, family, physicians, and other care providers. JAMA. 2000;284:2476–82.

    PubMed  CAS  Google Scholar 

  112. Drought TS, Koenig BA. “Choice” in end-of-life decision making: researching fact or fiction? Gerontologist. 2002;42:114–28.

    PubMed  Google Scholar 

  113. Chochinov HM. Dignity and the essence of medicine: the A, B, C, and D of dignity conserving care. BMJ. 2007;335:184–7.

    PubMed  PubMed Central  Google Scholar 

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Correspondence to Manuel Martínez-Sellés MD, PhD .

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Díez-Villanueva, P., Martínez-Sellés, M. (2015). End-of-Life Care in Hospitalized Patients with Cardiovascular and Cerebrovascular Disease. In: Goodlin, S., Rich, M. (eds) End-of-Life Care in Cardiovascular Disease. Springer, London. https://doi.org/10.1007/978-1-4471-6521-7_4

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