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Neurodegenerative Diseases pp 65–76Cite as

The Role of Cerebrovascular Disease in Cognitive Decline

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Abstract

Vascular risk factors and cerebrovascular disease are recognized factors implicated in the evolution toward dementia, not only of vascular origin but also degenerative dementia as Alzheimer’s disease. Even among nondemented subjects, hypertension, diabetes, and stroke are associated with worse performance in attention, executive functions, and speed and motor control. Influence of vascular risk factors in cognition starts early in life. Treatment and control of vascular risk factors since early ages has a key role in order to prevent cognitive impairment associated with aging. Cerebral white matter changes have gained attention in the last decades and can represent a potential outcome in experimental studies aiming to reduce cerebrovascular burden.

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Authors and Affiliations

  1. Department of Neurosciences, Hospital de Santa Maria, University of Lisbon, Av prof, Egas Moniz, Lisbon, Portugal

    Ana Verdelho PhD, MD

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  1. Ana Verdelho PhD, MD
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Correspondence to Ana Verdelho PhD, MD .

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  1. Neurology Unit, Alzheimer Center, Neurology Unit, University of Milan, Fondazione Ca’ Granda, IRCCS Ospedale Policlinico, Milan, Italy

    Daniela Galimberti

  2. Neurology Unit, Alzheimer Center, Neurology Unit, University of Milan, Fondazione Ca’ Granda, IRCCS Ospedale Policlinico, Milan, Italy

    Elio Scarpini

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Verdelho, A. (2014). The Role of Cerebrovascular Disease in Cognitive Decline. In: Galimberti, D., Scarpini, E. (eds) Neurodegenerative Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-6380-0_5

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  • DOI: https://doi.org/10.1007/978-1-4471-6380-0_5

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