Non-invasive Monitoring of Skin-Containing Vascularized Composite Allotransplantation

  • Huseyin Karagoz
  • Mehmet Salih Gurel
  • Fatih Zor


Monitoring of allograft rejection is critical to be able to provide proper immunosuppressive treatment following allotransplantation. Skin biopsy is needed to prove and to grade of rejection according to the current protocols, but it is an invasive and time-consuming method. An experimental study was performed to describe a non-invasive monitoring of allograft rejection. Five skin-containing vascularized composite allotransplantations were performed on rats, and allograft rejection was evaluated with reflectance confocal microscopy and also with skin biopsy. All data obtained from the study were evaluated and compared statistically. Reflectance confocal microscopy is presented as a new non-invasive rejection monitoring technique, and the new allograft rejection scoring system is recommended based on the results of this experimental study in this chapter.


Monitoring Reflectance confocal microscopy Rejection Scoring Vascularized composite allotransplantation 


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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  • Huseyin Karagoz
    • 1
  • Mehmet Salih Gurel
    • 2
  • Fatih Zor
    • 3
  1. 1.Department of Plastic and Reconstructive SurgeryGulhane Military Medical Academy, Haydarpasa Training HospitalIstanbulTurkey
  2. 2.Department of DermatologyIstanbul Training and Research HospitalIstanbulTurkey
  3. 3.Department of Plastic and Reconstructive SurgeryGulhane Military Medical AcademyAnkaraTurkey

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