Abstract
Pulsed Acoustic Cellular Expression (PACE) is a novel technology utilizing Extracorporeal Shock Waves (ESW) in as a source of acoustic energy in a pulsed manner capable of delivering a cellular expression response. It has multiple indications in medicine but exact mechanism of PACE remains unknown. In our experiment in a large group of animals we checked influence of PACE on microcirculation in a well-known model of rats’ cremaster muscle. Results revealed that PACE therapy increases circulation in cremaster muscle and causes neovascularization and angiogenesis. It also has anti-inflammatory effect on the muscle. To achieve desired results PACE therapy has to be used periodically.
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Abbreviations
- CCL2:
-
Chemokine (C-C motif) ligand 2
- CCR2:
-
Chemokine (C-C motif) receptor 2
- CXCL5:
-
Chemokine (C-X-C motif) ligand 5
- eNOS:
-
Endothelial nitric oxide synthase
- ESW:
-
Extracorporeal Shock Waves
- ESWT:
-
Extracorporeal Shock Wave Technology
- I/R:
-
Ischemia/Reperfusion
- iNOS:
-
Inducible nitric oxide synthase
- PACE:
-
Pulsed Acoustic Cellular Expression
- RBC:
-
Red Blood Cells
- VEGF:
-
Vascular endothelial growth factor
- vWF:
-
von Willebrand factor
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Krokowicz, L., Mielniczuk, M. (2015). Microcirculation and Pace Therapy. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_17
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DOI: https://doi.org/10.1007/978-1-4471-6335-0_17
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