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Size Matters: Intervention Thresholds for Dissection Prophylaxis in the Ascending Aorta

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Abstract

This chapter provides an extensive review of the normal size of the ascending aorta, for different body surface areas including tall people. The different imaging techniques, by means of echocardiography, magnetic resonance and computed tomography, are extensively discussed, as well as pitfalls in size measurements. The size of the ascending aorta may increase due to aging or pathologic conditions. The authors consider an aortic root or ascending aorta diameter above 4.0 cm as abnormal. From a diameter of >4.0 cm begins a monitor-zone for extended diagnostic evaluation, treatment advices and pre-pregnancy counselling. From a diameter >4.5 cm, operative treatment of the ascending aorta is advised in patients with connective tissue disorders who have risk factors. From a diameter of >5.0 cm, operative treatment is advised in other cases of connective tissue disorders and in cases of bicuspid aortic valve with risk factors. From a diameter of >5.5 cm, operative treatment is advised in bicuspid aortic valve without risk factors and in all other cases.

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References

  1. Erbel R, Alfonso F, Boileau C, Dirsch O, Eber B, Haverich A, et al. Diagnosis and management of aortic dissection. Eur Heart J. 2001;22(18):1642–81.

    Article  CAS  PubMed  Google Scholar 

  2. Cozijnsen L, Braam RL, Waalewijn RA, Schepens MA, Loeys BL, van Oosterhout MF, et al. What is new in dilatation of the ascending aorta? Review of current literature and practical advice for the cardiologist. Circulation. 2011;123(8):924–8.

    Article  PubMed  Google Scholar 

  3. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, Casey Jr DE, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation. 2010;121(13):e266–369.

    Article  PubMed  Google Scholar 

  4. Roman MJ, Devereux RB, Kramer-Fox R, O’Loughlin J. Two-dimensional echocardiographic aortic root dimensions in normal children and adults. Am J Cardiol. 1989;64(8):507–12.

    Article  CAS  PubMed  Google Scholar 

  5. Vasan RS, Larson MG, Levy D. Determinants of echocardiographic aortic root size. Framingham Heart Study Circ. 1995;91(3):734–40.

    Article  CAS  Google Scholar 

  6. Drexler M, Erbel R, Muller U, Wittlich N, Mohr-Kahaly S, Meyer J. Measurement of intracardiac dimensions and structures in normal young adult subjects by transesophageal echocardiography. Am J Cardiol. 1990;65(22):1491–6.

    Article  CAS  PubMed  Google Scholar 

  7. Agmon Y, Khandheria BK, Meissner I, Schwartz GL, Sicks JD, Fought AJ, et al. Is aortic dilatation an atherosclerosis-related process? Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation. J Am Coll Cardiol. 2003;42(6):1076–83.

    Article  PubMed  Google Scholar 

  8. Garcier JM, Petitcolin V, Filaire M, Mofid R, Azarnouch K, Ravel A, et al. Normal diameter of the thoracic aorta in adults: a magnetic resonance imaging study. Surg Radiol Anat. 2003;25(3–4):322–9.

    Article  PubMed  Google Scholar 

  9. Aronberg DJ, Glazer HS, Madsen K, Sagel SS. Normal thoracic aortic diameters by computed tomography. J Comput Assist Tomogr. 1984;8(2):247–50.

    CAS  PubMed  Google Scholar 

  10. Gerstenblith G, Frederiksen J, Yin FC, Fortuin NJ, Lakatta EG, Weisfeldt ML. Echocardiographic assessment of a normal adult aging population. Circulation. 1977;56(2):273–8.

    Article  CAS  PubMed  Google Scholar 

  11. Lam CS, Xanthakis V, Sullivan LM, Lieb W, Aragam J, Redfield MM, et al. Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study. Circulation. 2010;122(9):884–90.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Loeys BL, Dietz HC, Braverman AC, Callewaert BL, De BJ, Devereux RB, et al. The revised Ghent nosology for the Marfan syndrome. J Med Genet. 2010;47(7):476–85.

    Article  CAS  PubMed  Google Scholar 

  13. Rozendaal L, Groenink M, Naeff MS, Hennekam RC, Hart AA, Van Der Wall EE, et al. Marfan syndrome in children and adolescents: an adjusted nomogram for screening aortic root dilatation. Heart. 1998;79(1):69–72.

    CAS  PubMed Central  PubMed  Google Scholar 

  14. Radonic T, de Witte P, Groenink M, de Bruin-Bon R, Timmermans J, Scholte A, et al. Critical appraisal of the revised Ghent criteria for diagnosis of Marfan syndrome. Clin Genet. 2011;80:346–53.

    Article  CAS  PubMed  Google Scholar 

  15. Reed CM, Richey PA, Pulliam DA, Somes GW, Alpert BS. Aortic dimensions in tall men and women. Am J Cardiol. 1993;71(7):608–10.

    Article  CAS  PubMed  Google Scholar 

  16. Kinoshita N, Mimura J, Obayashi C, Katsukawa F, Onishi S, Yamazaki H. Aortic root dilatation among young competitive athletes: echocardiographic screening of 1929 athletes between 15 and 34 years of age. Am Heart J. 2000;139(4):723–8.

    Article  CAS  PubMed  Google Scholar 

  17. Pelliccia A, Di Paolo FM, De BE, Quattrini FM, Pisicchio C, Guerra E, et al. Prevalence and clinical significance of aortic root dilation in highly trained competitive athletes. Circulation. 2010;122(7):698–706, 3.

    Article  PubMed  Google Scholar 

  18. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440–63.

    Article  PubMed  Google Scholar 

  19. Lopez L, Colan SD, Frommelt PC, Ensing GJ, Kendall K, Younoszai AK, et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr. 2010;23(5):465–95.

    Article  PubMed  Google Scholar 

  20. Evangelista A, Flachskampf FA, Erbel R, Antonini-Canterin F, Vlachopoulos C, Rocchi G, et al. Echocardiography in aortic diseases: EAE recommendations for clinical practice. Eur J Echocardiogr. 2010;11(8):645–58.

    Article  PubMed  Google Scholar 

  21. Sheil ML, Jenkins O, Sholler GF. Echocardiographic assessment of aortic root dimensions in normal children based on measurement of a new ratio of aortic size independent of growth. Am J Cardiol. 1995;75(10):711–5.

    Article  CAS  PubMed  Google Scholar 

  22. Gautier M, Detaint D, Fermanian C, Aegerter P, Delorme G, Arnoult F, et al. Nomograms for aortic root diameters in children using two-dimensional echocardiography. Am J Cardiol. 2010;105(6):888–94.

    Article  PubMed  Google Scholar 

  23. Pettersen MD, Du W, Skeens ME, Humes RA. Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: an echocardiographic study. J Am Soc Echocardiogr. 2008;21(8):922–34.

    Article  PubMed  Google Scholar 

  24. Kaiser T, Kellenberger CJ, Albisetti M, Bergstrasser E, Valsangiacomo Buechel ER. Normal values for aortic diameters in children and adolescents—assessment in vivo by contrast-enhanced CMR-angiography. J Cardiovasc Magn Reson. 2008;10:56.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Burman ED, Keegan J, Kilner PJ. Aortic root measurement by cardiovascular magnetic resonance: specification of planes and lines of measurement and corresponding normal values. Circ Cardiovasc Imag. 2008;1(2):104–13.

    Article  Google Scholar 

  26. Mao SS, Ahmadi N, Shah B, Beckmann D, Chen A, Ngo L, et al. Normal thoracic aorta diameter on cardiac computed tomography in healthy asymptomatic adults: impact of age and gender. Acad Radiol. 2008;15(7):827–34.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Wolak A, Gransar H, Thomson LE, Friedman JD, Hachamovitch R, Gutstein A, et al. Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area. JACC Cardiovasc Imag. 2008;1(2):200–9.

    Article  Google Scholar 

  28. Kalsch H, Lehmann N, Mohlenkamp S, Becker A, Moebus S, Schmermund A, et al. Body-surface adjusted aortic reference diameters for improved identification of patients with thoracic aortic aneurysms: results from the population-based Heinz Nixdorf Recall study. Int J Cardiol. 2011;163(1):72–8.

    Article  PubMed  Google Scholar 

  29. Agarwal PP, Chughtai A, Matzinger FR, Kazerooni EA. Multidetector CT of thoracic aortic aneurysms. Radiographics. 2009;29(2):537–52.

    Article  PubMed  Google Scholar 

  30. Mendoza DD, Kochar M, Devereux RB, Basson CT, Min JK, Holmes K, et al. Impact of image analysis methodology on diagnostic and surgical classification of patients with thoracic aortic aneurysms. Ann Thorac Surg. 2011;92(3):904–12.

    Article  PubMed  Google Scholar 

  31. Jonker FH, van Keulen JW, Schlosser FJ, Indes JE, Moll FL, Verhagen HJ, et al. Thoracic aortic pulsatility decreases during hypovolemic shock: implications for stent-graft sizing. J Endovasc Ther. 2011;18(4):491–6.

    Article  PubMed  Google Scholar 

  32. van de Laar IM, van der Linde D, Oei EH, Bos PK, Bessems JH, Bierma-Zeinstra SM, et al. Phenotypic spectrum of the SMAD3-related aneurysms-osteoarthritis syndrome. J Med Genet. 2012;49(1):47–57.

    Article  PubMed  Google Scholar 

  33. van der Linde D, van de Laar IM, Bertoli-Avella AM, Oldenburg RA, Bekkers JA, Mattace-Raso FU, et al. Aggressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants. J Am Coll Cardiol. 2012;60(5):397–403.

    Article  PubMed  Google Scholar 

  34. van der Linde D, Bekkers JA, Mattace-Raso FU, van de Laar IM, Moelker A, van den Bosch AE, et al. Progression rate and early surgical experience in the new aggressive aneurysms-osteoarthritis syndrome. Ann Thorac Surg. 2012;95(2):563–9.

    Article  PubMed  Google Scholar 

  35. Tadros TM, Klein MD, Shapira OM. Ascending aortic dilatation associated with bicuspid aortic valve: pathophysiology, molecular biology, and clinical implications. Circulation. 2009;119(6):880–90.

    Article  PubMed  Google Scholar 

  36. Verheugt CL, Uiterwaal CS, Grobbee DE, Mulder BJ. Long-term prognosis of congenital heart defects: a systematic review. Int J Cardiol. 2008;131(1):25–32.

    Article  PubMed  Google Scholar 

  37. Oliver JM, Alonso-Gonzalez R, Gonzalez AE, Gallego P, Sanchez-Recalde A, Cuesta E, et al. Risk of aortic root or ascending aorta complications in patients with bicuspid aortic valve with and without coarctation of the aorta. Am J Cardiol. 2009;104(7):1001–6.

    Article  PubMed  Google Scholar 

  38. Della CA, Bancone C, Quarto C, Dialetto G, Covino FE, Scardone M, et al. Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression. Eur J Cardiothorac Surg. 2007;31(3):397–404.

    Article  Google Scholar 

  39. Della CA, Bancone C. Multiple aortopathy phenotypes with bicuspid aortic valve: the importance of terminology and definition criteria. Eur J Cardiothorac Surg. 2012;41(6):1404.

    Article  Google Scholar 

  40. Fazel SS, Mallidi HR, Lee RS, Sheehan MP, Liang D, Fleischman D, et al. The aortopathy of bicuspid aortic valve disease has distinctive patterns and usually involves the transverse aortic arch. J Thorac Cardiovasc Surg. 2008;135(4):901–7, 907.

    Article  PubMed  Google Scholar 

  41. Schaefer BM, Lewin MB, Stout KK, Gill E, Prueitt A, Byers PH, et al. The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape. Heart. 2008;94(12):1634–8.

    Article  CAS  PubMed  Google Scholar 

  42. Cotrufo M, Della CA. The association of bicuspid aortic valve disease with asymmetric dilatation of the tubular ascending aorta: identification of a definite syndrome. J Cardiovasc Med (Hagerstown). 2009;10(4):291–7.

    Article  Google Scholar 

  43. Elefteriades JA, Farkas EA. Thoracic aortic aneurysm clinically pertinent controversies and uncertainties. J Am Coll Cardiol. 2010;55(9):841–57.

    Article  CAS  PubMed  Google Scholar 

  44. Albornoz G, Coady MA, Roberts M, Davies RR, Tranquilli M, Rizzo JA, et al. Familial thoracic aortic aneurysms and dissections—incidence, modes of inheritance, and phenotypic patterns. Ann Thorac Surg. 2006;82(4):1400–5.

    Article  PubMed  Google Scholar 

  45. Coady MA, Davies RR, Roberts M, Goldstein LJ, Rogalski MJ, Rizzo JA, et al. Familial patterns of thoracic aortic aneurysms. Arch Surg. 1999;134(4):361–7.

    Article  CAS  PubMed  Google Scholar 

  46. Davies RR, Goldstein LJ, Coady MA, Tittle SL, Rizzo JA, Kopf GS, et al. Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size. Ann Thorac Surg. 2002;73(1):17–27.

    Article  PubMed  Google Scholar 

  47. Coady MA, Rizzo JA, Hammond GL, Mandapati D, Darr U, Kopf GS, et al. What is the appropriate size criterion for resection of thoracic aortic aneurysms? J Thorac Cardiovasc Surg. 1997;113(3):476–91.

    Article  CAS  PubMed  Google Scholar 

  48. Koullias G, Modak R, Tranquilli M, Korkolis DP, Barash P, Elefteriades JA. Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta. J Thorac Cardiovasc Surg. 2005;130(3):677–83.

    Article  PubMed  Google Scholar 

  49. Svensson LG, Kim KH, Lytle BW, Cosgrove DM. Relationship of aortic cross-sectional area to height ratio and the risk of aortic dissection in patients with bicuspid aortic valves. J Thorac Cardiovasc Surg. 2003;126(3):892–3.

    Article  PubMed  Google Scholar 

  50. Parish LM, Gorman III JH, Kahn S, Plappert T, St John-Sutton MG, Bavaria JE, et al. Aortic size in acute type A dissection: implications for preventive ascending aortic replacement. Eur J Cardiothorac Surg. 2009;35(6):941–5.

    Article  PubMed  Google Scholar 

  51. Pape LA, Tsai TT, Isselbacher EM, Oh JK, O’gara PT, Evangelista A, et al. Aortic diameter > or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD). Circulation. 2007;116(10):1120–7.

    Article  PubMed  Google Scholar 

  52. Nollen GJ, Groenink M, Tijssen JG, Van Der Wall EE, Mulder BJ. Aortic stiffness and diameter predict progressive aortic dilatation in patients with Marfan syndrome. Eur Heart J. 2004;25(13):1146–52.

    Article  PubMed  Google Scholar 

  53. Bonow RO. Bicuspid aortic valves and dilated aortas: a critical review of the ACC/AHA practice guidelines recommendations. Am J Cardiol. 2008;102(1):111–4.

    Article  PubMed  Google Scholar 

  54. Russo CF, Mazzetti S, Garatti A, Ribera E, Milazzo A, Bruschi G, et al. Aortic complications after bicuspid aortic valve replacement: long-term results. Ann Thorac Surg. 2002;74(5):S1773–6.

    Article  PubMed  Google Scholar 

  55. Januzzi JL, Isselbacher EM, Fattori R, Cooper JV, Smith DE, Fang J, et al. Characterizing the young patient with aortic dissection: results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol. 2004;43(4):665–9.

    Article  PubMed  Google Scholar 

  56. Guntheroth WG. A critical review of the American College of Cardiology/American Heart Association practice guidelines on bicuspid aortic valve with dilated ascending aorta. Am J Cardiol. 2008;102(1):107–10.

    Article  PubMed  Google Scholar 

  57. Michelena HI, Desjardins VA, Avierinos JF, Russo A, Nkomo VT, Sundt TM, et al. Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community. Circulation. 2008;117(21):2776–84.

    Article  PubMed Central  PubMed  Google Scholar 

  58. Tzemos N, Therrien J, Yip J, Thanassoulis G, Tremblay S, Jamorski MT, et al. Outcomes in adults with bicuspid aortic valves. JAMA. 2008;300(11):1317–25.

    Article  CAS  PubMed  Google Scholar 

  59. Michelena HI, Khanna AD, Mahoney D, Margaryan E, Topilsky Y, Suri RM, et al. Incidence of aortic complications in patients with bicuspid aortic valves. JAMA. 2011;306(10):1104–12.

    Article  CAS  PubMed  Google Scholar 

  60. Davies RR, Kaple RK, Mandapati D, Gallo A, Botta Jr DM, Elefteriades JA, et al. Natural history of ascending aortic aneurysms in the setting of an unreplaced bicuspid aortic valve. Ann Thorac Surg. 2007;83(4):1338–44.

    Article  PubMed  Google Scholar 

  61. Borger MA, Preston M, Ivanov J, Fedak PW, Davierwala P, Armstrong S, et al. Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease? J Thorac Cardiovasc Surg. 2004;128(5):677–83.

    Article  PubMed  Google Scholar 

  62. Goland S, Czer LS, De Robertis MA, Mirocha J, Kass RM, Fontana GP, et al. Risk factors associated with reoperation and mortality in 252 patients after aortic valve replacement for congenitally bicuspid aortic valve disease. Ann Thorac Surg. 2007;83(3):931–7.

    Article  PubMed  Google Scholar 

  63. Girdauskas E, Disha K, Raisin HH, Secknus MA, Borger MA, Kuntze T. Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation. Eur J Cardiothorac Surg. 2012;42:832–7.

    Article  PubMed  Google Scholar 

  64. McKellar SH, Michelena HI, Li Z, Schaff HV, Sundt III TM. Long-term risk of aortic events following aortic valve replacement in patients with bicuspid aortic valves. Am J Cardiol. 2010;106(11):1626–33.

    Article  PubMed  Google Scholar 

  65. Girdauskas E, Borger MA, Secknus MA, Girdauskas G, Kuntze T. Is aortopathy in bicuspid aortic valve disease a congenital defect or a result of abnormal hemodynamics? A critical reappraisal of a one-sided argument. Eur J Cardiothorac Surg. 2011;39(6):809–14.

    Article  PubMed  Google Scholar 

  66. Girdauskas E, Disha K, Borger MA, Kuntze T. Relation of bicuspid aortic valve morphology to the dilatation pattern of the proximal aorta: focus on the transvalvular flow. Cardiol Res Pract. 2012;2012:478259.

    PubMed Central  PubMed  Google Scholar 

  67. Kallenbach K. Moderate aneuryms of the ascending aorta in stenotic bicuspid aortic valve—life threatening or merely an epiphenomenon? Eur J Cardiothorac Surg. 2012;42:838–9.

    Article  PubMed  Google Scholar 

  68. Groenink M, Lohuis TA, Tijssen JG, Naeff MS, Hennekam RC, Van Der Wall EE, et al. Survival and complication free survival in Marfan’s syndrome: implications of current guidelines. Heart. 1999;82(4):499–504.

    CAS  PubMed Central  PubMed  Google Scholar 

  69. Bonow RO, Carabello BA, Kanu C, de Leon ACJ, Faxon DP, Freed MD, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation. 2006;114(5):e84–231.

    Article  PubMed  Google Scholar 

  70. Vahanian A, Baumgartner H, Bax J, Butchart E, Dion R, Filippatos G, et al. Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J. 2007;28(2):230–68.

    PubMed  Google Scholar 

  71. Warnes CA, Williams RG, Bashore TM, Child JS, Connolly HM, Dearani JA, et al. ACC/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease). Circulation. 2008;118(23):e714–833.

    Article  PubMed  Google Scholar 

  72. Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Galie N, et al. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). Eur Heart J. 2010;31(23):2915–57.

    Article  PubMed  Google Scholar 

  73. Guntheroth W. Risk of aortic dissection in patients with bicuspid aortic valves. Am J Cardiol. 2011;107(6):958.

    Article  PubMed  Google Scholar 

  74. Coady MA, Stockwell PH, Robich MP, Poppas A, Sellke FW. Should aortas in patients with bicuspid aortic valve really be resected at an earlier stage than tricuspid? CON Cardiol Clin. 2010;28(2):299–314.

    Article  Google Scholar 

  75. Wald O, Korach A, Shapira OM. Should aortas in patients with bicuspid aortic valve really be resected at an earlier stage than tricuspid? PRO Cardiol Clin. 2010;28(2):289–98.

    Article  Google Scholar 

  76. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H, The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS), et al. Guidelines on the management of valvular heart disease (version 2012). Eur J Cardiothorac Surg. 2012;33:2451–96.

    Google Scholar 

  77. Ates M. When should we replace the ascending aorta in Marfan syndrome? Eur J Cardiothorac Surg. 2007;31(2):331–2.

    Article  PubMed  Google Scholar 

  78. Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H, et al. Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med. 2006;355(8):788–98.

    Article  CAS  PubMed  Google Scholar 

  79. Aalberts JJ, van den Berg MP, Bergman JE, du Marchie Sarvaas GJ, Post JG, van Unen H, et al. The many faces of aggressive aortic pathology: Loeys-Dietz syndrome. Neth Heart J. 2008;16(9):299–304.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  80. Williams JA, Loeys BL, Nwakanma LU, Dietz HC, Spevak PJ, Patel ND, et al. Early surgical experience with Loeys-Dietz: a new syndrome of aggressive thoracic aortic aneurysm disease. Ann Thorac Surg. 2007;83(2):S757–63.

    Article  PubMed  Google Scholar 

  81. Hager A, Kaemmerer H, Rapp-Bernhardt U, Blucher S, Rapp K, Bernhardt TM, et al. Diameters of the thoracic aorta throughout life as measured with helical computed tomography. J Thorac Cardiovasc Surg. 2002;123(6):1060–6.

    Article  PubMed  Google Scholar 

  82. Kaplan S, Aronow WS, Lai H, DeLuca AJ, Weiss MB, Dilmanian H, et al. Prevalence of an increased ascending and descending thoracic aorta diameter diagnosed by multislice cardiac computed tomography in men versus women and in persons aged 23 to 50 years, 51 to 65 years, 66 to 80 years, and 81 to 88 years. Am J Cardiol. 2007;100(10):1598–9.

    Article  PubMed  Google Scholar 

  83. Lin FY, Devereux RB, Roman MJ, Meng J, Jow VM, Jacobs A, et al. Assessment of the thoracic aorta by multidetector computed tomography: age- and sex-specific reference values in adults without evident cardiovascular disease. J Cardiovasc Comput Tomogr. 2008;2(5):298–308.

    Article  PubMed  Google Scholar 

  84. Lu TL, Huber CH, Rizzo E, Dehmeshki J, von Segesser LK, Qanadli SD. Ascending aorta measurements as assessed by ECG-gated multi-detector computed tomography: a pilot study to establish normative values for transcatheter therapies. Eur Radiol. 2009;19(3):664–9.

    Article  PubMed  Google Scholar 

  85. Mulder BJ. The distal aorta in the Marfan syndrome. Neth Heart J. 2008;16(11):382–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  86. Engelfriet PM, Boersma E, Tijssen JG, Bouma BJ, Mulder BJ. Beyond the root: dilatation of the distal aorta in Marfan’s syndrome. Heart. 2006;92(9):1238–43.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  87. Engelfriet P, Mulder B. Is there benefit of beta-blocking agents in the treatment of patients with the Marfan syndrome? Int J Cardiol. 2007;114(3):300–2.

    Article  PubMed  Google Scholar 

  88. Patel HJ, Deeb GM. Ascending and arch aorta: pathology, natural history, and treatment. Circulation. 2008;118(2):188–95.

    Article  PubMed  Google Scholar 

  89. Hartog AW, Franken R, Zwinderman AH, Groenink M, Mulder BJ. Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome. Expert Opin Pharmacother. 2012;13(5):647–62.

    Article  CAS  PubMed  Google Scholar 

  90. Maron BJ, Zipes DP. Introduction: eligibility recommendations for competitive athletes with cardiovascular abnormalities-general considerations. J Am Coll Cardiol. 2005;45(8):1318–21.

    Article  PubMed  Google Scholar 

  91. Maron BJ, Chaitman BR, Ackerman MJ, de Bayes LA, Corrado D, Crosson JE, et al. Recommendations for physical activity and recreational sports participation for young patients with genetic cardiovascular diseases. Circulation. 2004;109(22):2807–16.

    Article  PubMed  Google Scholar 

  92. Sarsam MA, Yacoub M. Remodeling of the aortic valve anulus. J Thorac Cardiovasc Surg. 1993;105(3):435–8.

    CAS  PubMed  Google Scholar 

  93. David TE, Feindel CM. An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta. J Thorac Cardiovasc Surg. 1992;103(4):617–21.

    CAS  PubMed  Google Scholar 

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Cozijnsen, L., Braam, R.L., Schepens, M.A.A.M., Mulder, B.J.M. (2014). Size Matters: Intervention Thresholds for Dissection Prophylaxis in the Ascending Aorta. In: Bonser, R., Pagano, D., Haverich, A., Mascaro, J. (eds) Controversies in Aortic Dissection and Aneurysmal Disease. Springer, London. https://doi.org/10.1007/978-1-4471-5622-2_4

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