Toxic Trauma pp 165-174 | Cite as

The Longer-Term Consequences of Toxic Trauma

  • David J. Baker


The period up to 24 h following the emergency management of acute toxic exposure is of critical importance in the prevention and recognition of developing pathology with a longer latency. The nervous system may develop a re-paralysis following the depolarising paralysis of the acute cholinergic system. This re-paralysis is a non-depolarising block, known as intermediate syndrome and may indicate a conformational change in the acetylcholine receptors in the neuromuscular junction leading to a failure of transmission and subsequent muscle paralysis. After a week following exposure to organophosphate (OP) pesticides, the peripheral nervous system may also develop OP-induced delayed neuropathy (OIPDN). In the lungs, toxic pulmonary oedema may develop after 12–24 h following exposure to lung-damaging agents. Resting a patient at risk, using steroids and applying appropriate protective artificial ventilation measures may modify the onset of pulmonary oedema and possibly acute respiratory distress syndrome.


Nerve Agent Methyl Isocyanate Chronic Laryngitis Acute Lung Injury Group Intermediate Syndrome 
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Further Reading

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Hôpital Necker—Enfants MaladesSAMU de ParisParisFrance

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