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Core Concepts in Toxicology

  • Philip C. Burcham
Chapter

Abstract

Modern toxicology uses many distinctive terms and concepts during its efforts to explain toxic phenomena. Firstly, since a suitable umbrella term is needed for the types of substances that are of concern to toxicologists, this chapter explores linguistic nuances surrounding such words as poison, toxin, xenobiotic, endobiotic and toxicant. Next, the complications that can accompany study of toxicity due to differences in the duration of chemical exposure are explored as determinants of toxic responses. The importance of dose in governing the severity of toxicity after chemical exposure is surveyed, together with the role of individual factors in predisposing susceptible subpopulations to exaggerated toxic responses. The possibility of interactions between chemicals in complex ‘real-world’ exposure scenarios involving simultaneous exposure to more than one substance is also considered. The role of lifestyle factors in shaping individual susceptibility to chemical toxicity is also highlighted, as is the timing of the manifestation of toxicity following toxicant exposure.

Keywords

allergies dose idiosyncratic toxicity latent toxicity local toxicity obesogens poison toxicant systemic toxicity xenobiotic 

Going Further

  1. Altenburger R et al. Mixture toxicity revisited from a toxicogenomic perspective. Environ Sci Technol. 2012;46:2508–22.PubMedCrossRefGoogle Scholar
  2. Boelsterli UA. Mechanistic toxicology: the molecular basis of how chemicals disrupt biological targets. 2nd ed. Boca Raton: CRC Press; 2007.Google Scholar
  3. Boobis A et al. Drug interactions. Drug Metab Rev. 2009;41:486–527.PubMedCrossRefGoogle Scholar
  4. Daly AK, Day CP. Genetic association studies in drug-induced liver injury. Drug Metab Rev. 2012;44:116–26.PubMedCrossRefGoogle Scholar
  5. Dolton MJ et al. Fruit juices as perpetrators of drug interactions: the role of organic anion-transporting polypeptides. Clin Pharmacol Ther. 2012;92:622–30.PubMedCrossRefGoogle Scholar
  6. Fraga MF et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A. 2005;102:10604–9.PubMedCrossRefGoogle Scholar
  7. Frank P, Ottoboni MA. The dose makes the poison: a plain-language guide to toxicology. Hoboken: Wiley; 2011.Google Scholar
  8. Gilbert SG. A small dose of toxicology: the health effects of common chemicals. Boca Raton: CRC Press; 2004.Google Scholar
  9. Josephy PD, Mannervik B. Molecular toxicology. 2nd ed. New York: Oxford University Press; 2006.Google Scholar
  10. Klaassen CD, Watkins JB. Casarett & Doull’s essentials of toxicology. 2nd ed. New York: McGraw-Hill Professional; 2010.Google Scholar
  11. Klassen CD. Casarett and Doull’s toxicology: the basic science of poisons. 8th ed. New York: McGraw-Hill Professional; 2013.Google Scholar
  12. La Merril M et al. Toxicological function of adipose tissue: focus on persistent organic pollutants. Environ Health Perspect. 2013;121:162–9.Google Scholar
  13. McQueen CA (Editor in Chief). Comprehensive toxicology, 14 Volumes. Kidlington: Elsevier; 2010.Google Scholar
  14. Pavlos R et al. HLA and pharmacogenetics of drug hypersensitivity. Pharmacogenomics. 2012;13:1285–306.PubMedCrossRefGoogle Scholar
  15. Timbrell TA. Principles of biochemical toxicology. 4th ed. Boca Raton: CRC Press; 2008.Google Scholar
  16. Titus-Ernstoff L et al. Offspring of women exposed in utero to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation. Epidemiology. 2008;19:251–7.PubMedCrossRefGoogle Scholar
  17. Veurink M et al. The history of DES, lessons to be learned. Pharm World Sci. 2005;27:139–43.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Philip C. Burcham
    • 1
  1. 1.School of Medicine and PharmacologyThe University of Western AustraliaPerthAustralia

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