Abstract
This chapter aims to provide a pragmatic approach to the management of patients with CKD. First, we must correctly identify those with CKD, impart the information to the patient in an informative and appropriate way and then offer strategies to ameliorate the complications of CKD and prevent progression of the kidney disease.
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References
Methven S, Macgregor MS, Traynor JP, O’Reilly DS, Deighan CJ. Reply to ‘improving the interpretation of protein: creatinine ratios. The impact of creatinine excretion’. Nephrol Dial Transplant. 2011;26(3):1109.
Methven S, Macgregor MS, Traynor JP, O’Reilly DS, Deighan CJ. Assessing proteinuria in chronic kidney disease: protein-creatinine ratio versus albumin-creatinine ratio. Nephrol Dial Transplant. 2010;25:2991–6.
KDIGO Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2013;3(1):1.
CKD Prognosis Consortium. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375(9731):2073.
Halbesma N, Kuiken DS, Brantsma AH, Bakker SJ, Wetzels JF, De Zeeuw D, et al. Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screening. J Am Soc Nephrol. 2006;17(9):2582–90.
Manns B, Hemmelgarn B, Tonelli M, Au F, Chiasson TC, Dong J, et al. Population based screening for chronic kidney disease: cost effectiveness study. BMJ. 2010;341:c5869.
Gifford FJ, Methven S, Boag DE, Spalding EM, Macgregor MS. Chronic kidney disease prevalence and secular trends in a UK population: the impact of MDRD and CKD-EPI formulae. QJM. 2011;104(12):1045–53.
Lee BJ, Forbes K. The role of specialists in managing the health of populations with chronic illness: the example of chronic kidney disease. BMJ. 2009;339:b2395.
Rayner HC, Hollingworth L, Higgins R, Dodds S. Systematic kidney disease management in a population with diabetes mellitus: turning the tide of kidney failure. BMJ Qual Saf. 2011;20(10):903–10.
Stoves J, Connolly J, Cheung CK, Grange A, Rhodes P, O’Donoghue D, et al. Electronic consultation as an alternative to hospital referral for patients with chronic kidney disease: a novel application for networked electronic health records to improve the accessibility and efficiency of healthcare. Qual Saf Health Care. 2010;19(5):e54.
National Collaborating Centre for Chronic Conditions. Chronic kidney disease: national clinical guideline for early identification and management in adults in primary and secondary care. London: Royal College of Physicians; 2008.
Bowling CB, Inker LA, Gutierrez OM, Allman RM, Warnock DG, McClellan W, et al. Age-specific associations of reduced estimated glomerular filtration rate with concurrent chronic kidney disease complications. Clin J Am Soc Nephrol. 2011;6(12):2822–8.
Emamian SA, Nielsen MB, Pedersen JF, Ytte L. Kidney dimensions at sonography: correlation with age, sex, and habitus in 665 adult volunteers. AJR Am J Roentgenol. 1993;160(1):83–6.
Moghazi S, Jones E, Schroepple J, Arya K, McClellan W, Hennigar RA, et al. Correlation of renal histopathology with sonographic findings. Kidney Int. 2005;67(4):1515–20.
Johnson S, Rishi R, Andone A, Khawandi W, Al-Said J, Gletsu-Miller N, et al. Determinants and functional significance of renal parenchymal volume in adults. Clin J Am Soc Nephrol. 2011;6(1):70–6.
Tomson CR. Indications for renal biopsy in chronic kidney disease. Clin Med. 2003;3(6):513–7.
Wilson FP, Sheehan JM, Mariani LH, Berns JS. Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality. Nephrol Dial Transplant. 2012;27(11):4088–94.
Lambers Heerspink HJ, de Zeeuw D. Debate: PRO position. Should microalbuminuria ever be considered as a renal endpoint in any clinical trial? Am J Nephrol. 2010;31(5):458,61.
Tangri N, Stevens LA, Griffith J, Tighiouart H, Djurdjev O, Naimark D, et al. A predictive model for progression of chronic kidney disease to kidney failure. JAMA. 2011;305(15):1553–9.
Lambers Heerspink HJ, Navis G, Ritz E. Salt intake in kidney disease–a missed therapeutic opportunity? Nephrol Dial Transplant. 2012;27(9):3435–42.
van den Berg E, Geleijnse JM, Brink EJ, van Baak MA, Homan van der Heide JJ, Gans RO, et al. Sodium intake and blood pressure in renal transplant recipients. Nephrol Dial Transplant. 2012;27(8):3352–9.
Lambers Heerspink HJ, Holtkamp FA, Parving HH, Navis GJ, Lewis JB, Ritz E, et al. Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers. Kidney Int. 2012;82(3):330–7.
Heerspink HL, Ritz E. Sodium chloride intake: is lower always better? J Am Soc Nephrol. 2012;23(7):1136–9.
Vallon V, Thomson SC. Anomalous role for dietary salt in diabetes mellitus? Nat Rev Endocrinol. 2011;7(7):377–8.
Heiwe S, Jacobson SH. Exercise training for adults with chronic kidney disease. Cochrane Database Syst Rev. 2011;(10):CD003236.
Holtkamp FA, de Zeeuw D, Thomas MC, Cooper ME, de Graeff PA, Hillege HJ, et al. An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function. Kidney Int. 2011;80(3):282–7.
Hou FF, Xie D, Zhang X, Chen PY, Zhang WR, Liang M, et al. Renoprotection of optimal antiproteinuric doses (ROAD) study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency. J Am Soc Nephrol. 2007;18(6):1889–98.
Mann JF, Schmieder RE, McQueen M, Dyal L, Schumacher H, Pogue J, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet. 2008;372(9638):547–53.
Fried LF, Emanuele N, Zhang JH, Brophy M, Connor TA, Duckworth W, et al. Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med. 2013;369:1892–1903.
Bakris GL, Weir MR, DeQuattro V, McMahon FG. Effects of an ACE inhibitor/calcium antagonist combination on proteinuria in diabetic nephropathy. Kidney Int. 1998;54(4):1283–9.
Husted FC, Nolph KD, Maher JF. NaHCO3 and NaC1 tolerance in chronic renal failure. J Clin Invest. 1975;56(2):414–9.
Weinberger MH. Sodium chloride and blood pressure. N Engl J Med. 1987;317(17):1084–6.
Douglas K, O’Malley PG, Jackson JL. Meta-analysis: the effect of statins on albuminuria. Ann Intern Med. 2006;145(2):117–24.
Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (study of heart and renal protection): a randomised placebo-controlled trial. Lancet. 2011;377(9784):2181–92.
Rutter MK, Prais HR, Charlton-Menys V, Gittins M, Roberts C, Davies RR, et al. Protection against nephropathy in diabetes with atorvastatin (PANDA): a randomized double-blind placebo-controlled trial of high- vs. low-dose atorvastatin(1). Diabet Med. 2011;28(1):100–8.
Helps A, Deighan C, Gourlay Y, Seaton RA. Gentamicin and acute kidney injury requiring renal replacement therapy in the context of a restrictive antibiotic policy. J Antimicrob Chemother. 2011;66(8):1936–8.
Wingard RL, Pupim LB, Krishnan M, Shintani A, Ikizler TA, Hakim RM. Early intervention improves mortality and hospitalization rates in incident hemodialysis patients: RightStart program. Clin J Am Soc Nephrol. 2007;2(6):1170–5.
Barrett BJ, Garg AX, Goeree R, Levin A, Molzahn A, Rigatto C, et al. A nurse-coordinated model of care versus usual care for stage 3/4 chronic kidney disease in the community: a randomized controlled trial. Clin J Am Soc Nephrol. 2011;6(6):1241–7.
Hopkins RB, Garg AX, Levin A, Molzahn A, Rigatto C, Singer J, et al. Cost-effectiveness analysis of a randomized trial comparing care models for chronic kidney disease. Clin J Am Soc Nephrol. 2011;6(6):1248–57.
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Appendix
Appendix
My Kidney Care Plan
Name ……………………………….
Hospital number …………………..
Welcome to the Chronic Kidney Disease (CKD) Service (designed by Katy Gerrard)
This is your care plan; it will help all members of your healthcare team (including your GP) to care for you. Hopefully it will also help you understand and get involved in your kidney problems and plans for treatment.
Please bring it with you to every appointment and also if you get admitted to hospital or go to your GP.
The chronic kidney disease team is a group of renal specialists who help manage people with kidney problems. As well as running clinics at the Royal Free Hospital, we also run clinics at Barnet Hospital, Mary Rankin (St. Pancras) and North Middlesex Hospital.
Your nurses are: ………………………………………………………..
Your consultant is: ………………………………………………………………………………………………….
The specialist nurses and doctors in this team work alongside dieticians, social workers, psychologists, your primary care team (GP surgery) and of course you and your family/carers to manage your kidney problems.
We can help with many aspects of kidney problems in our clinic, including:
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Further monitoring and stabilisation of your kidney function
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Management of any associated symptoms or complications you may have
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Anaemia (blood count) management
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General health and wellbeing promotion
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Preparation for dialysis
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Assessing whether you are physically fit enough for a kidney transplant
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Conservative management if you choose not to have dialysis
We are happy to discuss any/all of the above issues with you and also any other matters you are concerned about. You will still continue to see a renal doctor (specialist) regularly.
All your other day-to-day health problems will still be managed by your general practitioner (GP). We recommend that you take this care plan with you when you attend your GP surgery.
If you need to contact us about any kidney-related problems then you can call us on ………… (office hours). We might not be able to answer your call straight away as we run clinics every day, but we will return your call as soon as we can. If the problem is urgent, then please contact your GP or go straight to your nearest Accident and Emergency.
Lifestyle
There are many things you can do to try and keep yourself healthy:
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We recommend that you follow a balanced healthy diet and do not eat salty foods or add extra salt to your food.
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Some patients need to follow specific diets like low potassium or low phosphate; we will advise you, if you are one of these patients – you can use this section of your folder to insert relevant diet sheets. We also have dieticians who you will be able to see. If you want to contact the dieticians, please call ext 31719.
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It is beneficial to take regular exercise as your condition allows.
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If you smoke, we strongly advise that you stop as it will damage your kidneys further. Your GP will be able to provide help for you to stop smoking.
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We recommend that you do not drink too much alcohol; this is no more than 14 units for women and 21 for men per week.
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It is advisable to be a healthy weight; we will recommend what weight is ideal for you.
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High blood pressure (BP) damages kidneys further, so it is very important that you make sure your BP is well controlled. We will advise you what your BP should be.
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If you are diabetic, it is vital that your diabetes is well controlled as high blood sugars will damage the kidneys further; your healthcare team can help you with this.
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It is advisable that blood is taken from the veins in your hands; if this is not possible, then your dominant arm can be used; this is in case we need to make a fistula for dialysis.
My medication list | |||
---|---|---|---|
Medication | Dose | Frequency | Function |
|
My Test Results
If you would like to know your blood test results, they can be included here.
 | Target range | __/__/__ | __/__/__ | __/__/__ | __/__/__ | __/__/__ | __/__/__ |
---|---|---|---|---|---|---|---|
eGFR | Â | Â | Â | Â | Â | Â | Â |
Urea | Â | Â | Â | Â | Â | Â | Â |
Creatinine | Â | Â | Â | Â | Â | Â | Â |
Calcium | Â | Â | Â | Â | Â | Â | Â |
Potassium | Â | Â | Â | Â | Â | Â | Â |
Phosphate | Â | Â | Â | Â | Â | Â | Â |
Haemoglobin | Â | Â | Â | Â | Â | Â | Â |
Blood pressure | Â | Â | Â | Â | Â | Â | Â |
Weight | Â | Â | Â | Â | Â | Â | Â |
Results Key
eGFR | Roughly the percentage of normal kidney functionI have left (on average people need to consider dialysis treatment with a level below 15 %) |
Urea | Waste level |
Creatinine | Waste level |
Calcium | Important for bone strength |
Potassium | A mineral, which if high can cause heart rhythm problems |
Phosphate | Important for bone strength and can cause itching if high |
Haemoglobin | Blood count |
Treatment Options
When/if your kidney function deteriorates, we will need to discuss treatment options. This is in order for us to make plans for your future care. You will be very central to the decision-making process, and so we will need to explain to you in detail about the options. You may wish to make notes about all of the options here.
You can change your decision at any time, but please discuss this with your nurse as soon as possible.
We also suggest that you discuss this with you family/carers.
Peritoneal Dialysis
……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
Haemodialysis/Home Haemodialysis
……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
Kidney Transplant
……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
Conservative Management
……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
Dates These Options Were Discussed
……………………………………………………..
Decision on Preferred Treatment Option
……………………………………………………….
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Tomson, C.R.V., Methven, S. (2014). Chronic Kidney Disease: Management. In: Harber, M. (eds) Practical Nephrology. Springer, London. https://doi.org/10.1007/978-1-4471-5547-8_48
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DOI: https://doi.org/10.1007/978-1-4471-5547-8_48
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