Skip to main content

Sickle Cell Disease and Other Haematological Disorders Involving the Kidney

  • Chapter
  • First Online:
Practical Nephrology

Abstract

Several haematological conditions have significant renal sequelae perhaps most notably multiple myeloma and the haemolytic uraemic syndrome spectrum of conditions, which are covered elsewhere. Renal disease is also associated with several red cell disorders including the haemoglobinopathies and other disorders that result in acute or chronic intravascular haemolysis. Aside from myeloma, most renal diseases related to white cell disorders are secondary to the systemic effects, direct infiltration or treatment of lymphoma or leukaemia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Guasch A, Navarrete J, Nass K, Zayas CF. Glomerular involvement in adults with sickle cell hemoglobinopathies: prevalence and clinical correlates of progressive renal failure. J Am Soc Nephrol. 2006;17:2228–35.

    Article  CAS  PubMed  Google Scholar 

  2. Scheinman JI. Sickle cell disease and the kidney. Nat Clin Pract Nephrol. 2009;5:78–88.

    Article  PubMed  Google Scholar 

  3. Wesson DE. The initiation and progression of sickle cell nephropathy. Kidney Int. 2002;61:2277–86.

    Article  PubMed  Google Scholar 

  4. Wang WC, Ware RE, Miller ST, Iyer RV, Casella JF, Minniti CP, Rana S, Thornburg CD, Rogers ZR, Kalpatthi RV, Barredo JC, Brown RC, Sarnaik SA, Howard TH, Wynn LW, Kutlar A, Armstrong FD, Files BA, Goldsmith JC, Waclawiw MA, Huang X, Thompson BW. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled Trial (BABY HUG). Lancet. 2011;377:1663–72.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Statius van Eps LW, Schouten H, La Porte-Wijsman LW, Struyker Boudier AM. The influence of red blood cell transfusions on the hyposthenuria and renal hemodynamics of sickle cell anemia. Clin Chim Acta. 1967;17:449–61.

    Article  CAS  PubMed  Google Scholar 

  6. Day TG, Drasar ER, Fulford T, Sharpe CC, Thein SL. Association between hemolysis and albuminuria in adults with sickle cell anemia. Haematologica. 2012;97:201–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Serjeant GR, Serjeant BE, Mason KP, Hambleton IR, Fisher C, Higgs DR. The changing face of homozygous sickle cell disease: 102 patients over 60 years. Int J Lab Hematol. 2009;31:585–96.

    Article  CAS  PubMed  Google Scholar 

  8. Nakano D, Pollock D. New concepts in endothelin control of sodium balance. Clin Exp Pharmacol Physiol. 2012;39(1):104–10.

    Article  CAS  PubMed  Google Scholar 

  9. Huang SH, Sharma AP, Yasin A, Lindsay RM, Clark WF, Filler G. Hyperfiltration affects accuracy of creatinine eGFR measurement. Clin J Am Soc Nephrol. 2011;6:274–80.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Baig MA, Lin YS, Rasheed J, Mittman N. Renal medullary carcinoma. J Natl Med Assoc. 2006;98:1171–4.

    PubMed Central  PubMed  Google Scholar 

  11. Alvarez O, Montane B, Lopez G, Wilkinson J, Miller T. Early blood transfusions protect against microalbuminuria in children with sickle cell disease. Pediatr Blood Cancer. 2006;47:71–6.

    Article  PubMed  Google Scholar 

  12. Becton LJ, Kalpatthi RV, Rackoff E, Disco D, Orak JK, Jackson SM, Shatat IF. Prevalence and clinical correlates of microalbuminuria in children with sickle cell disease. Pediatr Nephrol. 2010;25:1505–11.

    Article  PubMed  Google Scholar 

  13. Alvarez O, Miller ST, Wang WC, Luo Z, McCarville MB, Schwartz GJ, Thompson B, Howard T, Iyer RV, Rana SR, Rogers ZR, Sarnaik SA, Thornburg CD, Ware RE. Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled baby hug clinical trial for infants with sickle cell anemia. Pediatr Blood Cancer. 2012;59(4):668–74.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Hsieh MM, Kang EM, Fitzhugh CD, Link MB, Bolan CD, Kurlander R, Childs RW, Rodgers GP, Powell JD, Tisdale JF. Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. N Engl J Med. 2009;361:2309–17.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Powars DR, Elliott-Mills DD, Chan L, Niland J, Hiti AL, Opas LM, Johnson C. Chronic renal failure in sickle cell disease: risk factors, clinical course, and mortality. Ann Intern Med. 1991;115:614–20.

    Article  CAS  PubMed  Google Scholar 

  16. Saxena AK, Panhotra BR, Al-Arabi Al-Ghamdi AM. End-stage sickle cell nephropathy: determinants of reduced survival of patients on long-term hemodialysis. Saudi J Kidney Dis Transpl. 2004;15:174–5.

    PubMed  Google Scholar 

  17. Abbott KC, Hypolite IO, Agodoa LY. Sickle cell nephropathy at end-stage renal disease in the United States: patient characteristics and survival. Clin Nephrol. 2002;58:9–15.

    Article  CAS  PubMed  Google Scholar 

  18. Lai ME, Spiga A, Vacquer S, Carta MP, Corrias C, Ponticelli C. Renal function in patients with beta-thalassaemia major: a long-term follow-up study. Nephrol Dial Transplant. 2012;27(9):3547–51.

    Article  CAS  PubMed  Google Scholar 

  19. Inoue N, Murakami Y, Kinoshita T. Molecular genetics of paroxysmal nocturnal hemoglobinuria. Int J Hematol. 2003;77:107–12.

    Article  CAS  PubMed  Google Scholar 

  20. Qi K, Zhang XG, Liu SW, Yin Z, Chen XM, Wu D. Reversible acute kidney injury caused by paroxysmal nocturnal hemoglobinuria. Am J Med Sci. 2011;341:68–70.

    Article  PubMed  Google Scholar 

  21. Clark DA, Butler SA, Braren V, Hartmann RC, Jenkins Jr DE. The kidneys in paroxysmal nocturnal hemoglobinuria. Blood. 1981;57:83–9.

    CAS  PubMed  Google Scholar 

  22. Rimola J, Martin J, Puig J, Darnell A, Massuet A. The kidney in paroxysmal nocturnal haemoglobinuria: MRI findings. Br J Radiol. 2004;77:953–6.

    Article  CAS  PubMed  Google Scholar 

  23. Hillmen P, Elebute M, Kelly R, Urbano-Ispizua A, Hill A, Rother RP, Khursigara G, Fu CL, Omine M, Browne P, Rosse W. Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria. Am J Hematol. 2010;85:553–9.

    Article  CAS  PubMed  Google Scholar 

  24. Kelly RJ, Hill A, Arnold LM, Khursigara G, Kanagasundaram NS, Hillmen P. Eculizumab for patients with paroxysmal nocturnal hemoglobinuria (PNH) is effective during the maintenance of hemodialysis for end stage renal failure. Leuk Res. 2011;35:560–2.

    Article  CAS  PubMed  Google Scholar 

  25. Barsoum RS. Malarial acute renal failure. J Am Soc Nephrol. 2000;11:2147–54.

    CAS  PubMed  Google Scholar 

  26. Gronroos M. Long-term renal function following bone marrow transplantation. Bone Marrow Transplant. 2007;39:717–23.

    Article  CAS  PubMed  Google Scholar 

  27. Herrera Guillermo A, Turbat-Herrera EA. Renal diseases with organized deposits. An algorithmic approach to classification and clinicopathologic diagnosis. Arch Pathol Lab Med. 2010;134:512–31.

    CAS  PubMed  Google Scholar 

  28. Bach A. Prevalence and patterns of renal involvement in imaging of malignant lymphoproliferative diseases. Acta Radiol. 2012;53:343–8.

    Google Scholar 

  29. Barcos M. An autopsy study of 1206 acute and chronic leukemias (1958 to 1982). Cancer. 1987:827–37.

    Google Scholar 

  30. Audard V. Minimal change nephrotic syndrome and classical Hodgkin's lymphoma: report of 21 cases and review of the literature. Kidney Int. 2006;69:2251–60.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Claire Sharpe MBBS, PhD, FRCP .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag London

About this chapter

Cite this chapter

Sharpe, C., Horsfield, C.J., Harber, M. (2014). Sickle Cell Disease and Other Haematological Disorders Involving the Kidney. In: Harber, M. (eds) Practical Nephrology. Springer, London. https://doi.org/10.1007/978-1-4471-5547-8_31

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-5547-8_31

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-5546-1

  • Online ISBN: 978-1-4471-5547-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics