Connective Tissue/Degenerative Disorders

  • Clay Cockerell
  • Martin C. MihmJr.
  • Brian J. Hall
  • Cary Chisholm
  • Chad Jessup
  • Margaret Merola


Clinical: Autoimmune disorder of unclear etiology more commonly seen in females and black individuals. Presents with skin tightening and induration with a leathery, often shiny surface as well as alopecia. Areas of involvement include the face, trunk and fingers, and usually are bilateral with distal to proximal progression. Genetics are complex. Risk factors include HLA-DR3 or DR5 and a positive family history. Two subtypes exist: limited and diffuse cutaneous variants.


Elastic Fiber Ancillary Study Cutaneous Lupus Erythematosus Porphyria Cutanea Tarda Subacute Cutaneous Lupus Erythematosus 
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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Clay Cockerell
    • 1
  • Martin C. MihmJr.
    • 2
  • Brian J. Hall
    • 1
  • Cary Chisholm
    • 3
  • Chad Jessup
    • 4
  • Margaret Merola
    • 5
  1. 1.Department of DermatologyUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Department of DermatologyBrigham and Women’s HospitalBostonUSA
  3. 3.Department of Pathology and DermatopathologyCentral Texas Pathology LaboratoryWacoUSA
  4. 4.Department of DermatologyTufts Medical CenterBostonUSA
  5. 5.Department of PathologyBrigham and Women’s HospitalBostonUSA

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