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Anti-ischemic Therapy

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Pharmacological Treatment of Acute Coronary Syndromes

Part of the book series: Current Cardiovascular Therapy ((CCT))

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Abstract

In a simple way, myocardial ischemia is secondary to a disbalance between oxygen supply in relation to the metabolic demands of the myocardium. Figure 1.1 depicts the principal components of this equation. In acute coronary syndromes plaque rupture and thrombosis play a major role, but other factors that decrease oxygen supply or increase myocardial metabolic demands contribute to ischemia and may be the principal cause of acute ischemia in absence of plaque rupture or coronary artery stenosis.

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Authors and Affiliations

  1. Cardiology Department, Hospital Universitario La Paz, Instituto de Investigación La Paz IdiPaz, Paseo de la Castellana 261. Planta 1, Madrid, 28046, Spain

    Jose Lopez-Sendón MD, PhD & Esteban López de Sá MD, FESC

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  1. Jose Lopez-Sendón MD, PhD
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  2. Esteban López de Sá MD, FESC
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Correspondence to Jose Lopez-Sendón MD, PhD .

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Editors and Affiliations

  1. Servicio de Cardiología, Hospital Universitario Central de Asturias, Oviedo, Spain

    Pablo Avanzas

  2. Department of Cardiology, The Heart Center, Rigshospitalet University Hospital of Copenhagen,, Copenhagen, Denmark

    Peter Clemmensen

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Lopez-Sendón, J., de Sá, E.L. (2014). Anti-ischemic Therapy. In: Avanzas, P., Clemmensen, P. (eds) Pharmacological Treatment of Acute Coronary Syndromes. Current Cardiovascular Therapy. Springer, London. https://doi.org/10.1007/978-1-4471-5424-2_1

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  • DOI: https://doi.org/10.1007/978-1-4471-5424-2_1

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