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Non-linear Effects in the Respiratory Impedance

  • Clara Mihaela Ionescu
Part of the Series in BioEngineering book series (SERBIOENG)

Abstract

This chapter describes the non-linear effects in the respiratory signals and in the related measurement instrumentation during FOT tests. In order to do so, some improvements are brought to the classical FOT device and a mechanical, piston-based prototype FOT device is introduced. This prototype overcomes the limitations of the loudspeaker and allows generation of multisine signals below 4 Hz. The principle of sending detection lines in the frequency domain for characterizing odd and even non-linear contributions from a non-linear system are introduced to the reader as a theoretical basis for the further discussion of this chapter. Two detection methods are presented: a robust method based on multiple measurements and a fast method based on a single measurement. After having discussed the pitfalls of non-linear distortions from the measuring device itself, we discuss the non-linear contributions in the respiratory signals: pressure and flow. The non-linear effects are further quantified by means of a novel evaluation index. Then the variations in this novel index are analyzed in groups of asthma patients, COPD patients, and healthy volunteers. Finally, the link between the non-linear distortions and the lumped fractional order model parameters is introduced, thus completing the puzzle of this book.

Keywords

Frequency Response Function Excitation Signal Breathing Frequency Prototype Device Feedforward Compensation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Clara Mihaela Ionescu
    • 1
  1. 1.Department of Electrical Energy, Systems and AutomationGhent UniversityGentBelgium

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