Laser Therapy for Pigmented Lesions

  • Julia Wu
  • Jane Yoo
  • David J. GoldbergEmail author


Laser therapy of pigmented lesions is a very efficacious way of removing cosmetically unappealing lesions on the skin. It is generally very safe and case reports of using lasers on pigmented lesions date back nearly half a century ago. However, as with any treatment, there are important considerations both to ensure maximal effectiveness of treatment and also to prevent potentially damaging adverse outcomes. The ability to target melanin as a chromophore and its presence in the epidermis in common skin conditions such as lentigines allows for appealing and satisfying cosmetic results. Herein, the justification and approach to treating pigmented lesions will be discussed, along with practical concerns and future directions in treatment.


Pigmented lesions Lasers Q-switched 


  1. 1.
    Goldman L, Igelman JM, Richfield DF. Impact of the laser on nevi and melanomas. Arch Dermatol. 1964;90:71–5.PubMedCrossRefGoogle Scholar
  2. 2.
    Anderson RR, Parrish JA. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science. 1983;220:524–7.PubMedCrossRefGoogle Scholar
  3. 3.
    Murphy GF, Shepard RS, Paul BS, et al. Organelle-specific injury to melanin-containing cells in human skin by pulsed laser irradiation. Lab Invest. 1983;49:680–5.PubMedGoogle Scholar
  4. 4.
    Funayama E, Sasaki S, Furukawa H, et al. Effectiveness of combined pulsed dye and Q-switched ruby laser treatment for large to giant congenital melanocytic naevi. Br J Dermatol. 2012;167:1085–91.PubMedCrossRefGoogle Scholar
  5. 5.
    Ross EV, Smirnov M, Pankratov M, Altshuler G. Intense pulsed light and laser treatment of facial telangiectasias and dyspigmentation: some theoretical and practical comparisons. Dermatol Surg. 2005;31:1188–98.PubMedCrossRefGoogle Scholar
  6. 6.
    Trotter MJ, Tron VA, Hollingdale J, Rivers JK. Localized chrysiasis induced by laser therapy. Arch Dermatol. 1995;131:1411–4.PubMedCrossRefGoogle Scholar
  7. 7.
    Goldberg DJ. Current trends in intense pulsed light. J Clin Aesthet Dermatol. 2012;5:45–53.PubMedCentralPubMedGoogle Scholar
  8. 8.
    Kallio H, Paloheimo M, Maunuksela EL. Hyaluronidase as an adjuvant in bupivacaine-lidocaine mixture for retrobulbar/peribulbar block. Anesth Analg. 2000;91:934–7.PubMedCrossRefGoogle Scholar
  9. 9.
    Vano-Galvan S, Matarredona JA, Harto A, et al. Treatment of light-coloured solar lentigines with cryotherapy plus alexandrite laser. J Eur Acad Dermatol Venereol. 2009;23:850–2.PubMedCrossRefGoogle Scholar
  10. 10.
    Kagami S, Asahina A, Watanabe R, et al. Treatment of 153 Japanese patients with Q-switched alexandrite laser. Lasers Med Sci. 2007;22:159–63.PubMedCrossRefGoogle Scholar
  11. 11.
    Trelles MA, Allones I, Moreno-Arias GA, Velez M. Becker’s navus: a comparative study between erbium:YAG and Q-switched neodymium:YAG; clinical and histopathological findings. Br J Dermatol. 2005;152:308–13.PubMedCrossRefGoogle Scholar
  12. 12.
    Lee HS, Won CH, Lee DH, et al. Treatment of melasma in Asian skin using a fractional 1,550-nm laser: an open clinical study. Dermatol Surg. 2009;35:1499–504.PubMedCrossRefGoogle Scholar
  13. 13.
    Rokhsar CK, Fitzpatrick RE. The treatment of melasma with fractional photothermolysis: a pilot study. Dermatol Surg. 2005;31:1645–50.PubMedGoogle Scholar
  14. 14.
    Ashinoff R, Levine VJ, Soter NA. Allergic reactions to tattoo pigment after laser treatment. Dermatol Surg. 1995;21:291–4.PubMedGoogle Scholar
  15. 15.
    Fitzpatrick RE, Lupton JR. Successful treatment of treatment-resistant laser-induced pigment darkening of a cosmetic tattoo. Lasers Surg Med. 2000;27:358–61.PubMedCrossRefGoogle Scholar
  16. 16.
    Franca K, Chacon A, Ledon J, Savas J, Izakovic J, Nouri K. Lasers for cutaneous congenital vascular lesions: a comprehensive overview and update. Lasers Med Sci. 2013;28:1197–204.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Division of DermatologyMontefiore Medical Center, Albert Einstein College of MedicineBronxUSA
  2. 2.Department of DermatologyAlbert Einstein College of MedicineNew YorkUSA
  3. 3.Skin Laser & Surgery Specialists of New York and New JerseyHackensack University Medical CenterNew YorkUSA
  4. 4.Department of DermatologyMount Sinai School of Medicine, UMDNJ- New Jersey Medical SchoolNew YorkUSA
  5. 5.Fordham Law SchoolNew YorkUSA

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