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Channelopathies and Heart Disease

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Cardiac Arrhythmias

Abstract

Channelopathies represent diseases caused by mutations in the genes encoding ion channels or associated proteins. With the advent of novel electrophysiology and molecular biology techniques, a wide variety of ion channels have been identified in different regions of the working myocardium or conduction system, and their biophysical and pharmacological properties, as well as involvement in different pathophysiology processes, are thoroughly characterized. This wealth of knowledge offers a better understanding of the intricate chemical and electrical events underlying a large class of rare heart diseases, most of them associated with arrhythmias, and also reveals novel mechanisms in the most frequent cardiovascular diseases and their complications. Within the present chapter we tackled the challenging task of presenting a comprehensive review of this rapidly expanding domain, with the hope of rendering relevant information for specialists with an interest in this highly exciting field of research.

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Authors and Affiliations

  1. Department of Biophysics and Physiology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, Bucharest, 005095, Romania

    Bogdan Amuzescu MD, PhD & Bogdan Istrate PhD

  2. Themis Pathology SRL, HistoBest Diagnostics, Bucharest, Romania

    Sorin Musat MD, PhD

Authors
  1. Bogdan Amuzescu MD, PhD
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  2. Bogdan Istrate PhD
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  3. Sorin Musat MD, PhD
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Corresponding author

Correspondence to Bogdan Amuzescu MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Cardiology, Center Hospitalier Coutances, Coutances, France

    Ambrose S. Kibos

  2. Department of Internal Medicine Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    Bradley P. Knight

  3. Division of Cardiology, McGill University Health Center, Montreal, Québec, Canada

    Vidal Essebag

  4. Department of Cardiology, Miami Children's Hospital, Miami, Florida, USA

    Steven B. Fishberger

  5. School of Biology, Chemistry and Health, Manchester Metropolitan University, Manchester, United Kingdom

    Mark Slevin

  6. “Acad. Vasile Candea” Emergency Clinical Center for Cardiovascular Diseases, “Carol Davila” University of Medicine and Pharmacy, “Titu Maiorescu” University Faculty of Medicine,, Bucharest, Romania

    Ion C. Țintoiu

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Amuzescu, B., Istrate, B., Musat, S. (2014). Channelopathies and Heart Disease. In: Kibos, A., Knight, B., Essebag, V., Fishberger, S., Slevin, M., Țintoiu, I. (eds) Cardiac Arrhythmias. Springer, London. https://doi.org/10.1007/978-1-4471-5316-0_9

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