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Strategies for Restoring Cardiac Synchrony by Cardiac Pacing

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Cardiac Arrhythmias

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Abstract

As already demonstrated, the restoring of cardiac synchrony is a complex process which implies a detailed assessment of the pathology that needs to be restructured (such as cardiac conduction abnormalities, heart failure) and a particularized analysis of pacing alternatives. In brief, this predecisional analysis involves the anticipation of the hemodynamic response for each type of cardiac pacing. The two most corrected pacing parameters are the atrioventricular and interventricular delay; however, their optimization process is often difficult because of the lack of an exclusive pacing system optimization by which the cardiac parameters can be improved. In general, the optimization methods are classified as echocardiographic and non-echocardiographic methods, but the most used is the echocardiographic evaluation. Cardiac resynchronization therapy is basically the pacing of the free wall region of the left ventricle with a lead. It is of interest that the transvenous approach is the most frequently utilized method. Even so, the right ventricle apex lead insertion may have negative effects on the cardiac function as a result of negative effects on myocardial contractility. Conversely, the left ventricle lead insertion may have variable effects that depend on various factors such as coronary sinus anatomy, the degree of atrioventricular and interventricular dyssynchrony, and location of scars due to myocardial infarction. Lastly, cardiac pacing is the key element for assessing the responder or nonresponder status in case of patients diagnosed with heart failure, being achieved by a team that includes an electrophysiologist and a specialist in cardiac hemodynamic assessment by echocardiography.

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References

  1. Boyett MR, Dobrzynski H. The sinoatrial node is still setting the pace 100 years after its discovery. Circ Res. 2007;100(11):1543–5.

    CAS  PubMed  Google Scholar 

  2. Kim D, Shinohara T, Joung B, Maruyama M, Choi EK, On YK. Calcium dynamics and the mechanisms of atrioventricular junctional rhythm. J Am Coll Cardiol. 2010;56(10):805–12.

    CAS  PubMed Central  PubMed  Google Scholar 

  3. Grines CL, Bashore TM, Boudoulas H, Olson S, Shafer P, Wooley CF. Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony. Circulation. 1989;79(4):845–53.

    CAS  PubMed  Google Scholar 

  4. Bax JJ, Ansalone G, Breithardt OA, Derumeaux G, Leclercq C, Schalij MJ, Sogaard P, St John Sutton M, Nihoyannopoulos P. Echocardiographic evaluation of cardiac resynchronization therapy: ready for routine clinical use? A critical appraisal. J Am Coll Cardiol. 2004;44(1):1–9.

    PubMed  Google Scholar 

  5. Vardas PE, Auricchio A, Blanc JJ, Daubert JC, Drexler H, Ector H, Gasparini M, Linde C, Morgado FB, Oto A, Sutton R, Trusz-Gluza M, European Society of Cardiology, European Heart Rhythm Association. Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in collaboration with the European Heart Rhythm Association. Eur Heart J. 2007;28(18):2256–95.

    PubMed  Google Scholar 

  6. Smiseth OA, Russell K, Skulstad H. The role of echocardiography in quantification of left ventricular dyssynchrony: state of the art and future directions. Eur Heart J Cardiovasc Imaging. 2012;13(1):61–8.

    PubMed  Google Scholar 

  7. Epstein AE, DiMarco JP, Ellenbogen KA, Estes 3rd NA, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO, Smith Jr SC, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Faxon DP, Halperin JL, Hiratzka LF, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW, American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices), American Association for Thoracic Surgery, Society of Thoracic Surgeons. ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol. 2002;51(21):e1–62.

    Google Scholar 

  8. Nagueh SF. Mechanical dyssynchrony in congestive heart failure: diagnostic and therapeutic implications. J Am Coll Cardiol. 2008;51(1):18–22.

    PubMed  Google Scholar 

  9. Kass DA. An epidemic of dyssynchrony: but what does it mean? J Am Coll Cardiol. 2008;51(1):12–7.

    PubMed  Google Scholar 

  10. Bax JJ, Gorcsan III J. Echocardiography and noninvasive imaging in cardiac resynchronization therapy: results of the PROSPECT (Predictors of Response to Cardiac Resynchronization Therapy) study in perspective. J Am Coll Cardiol. 2009;53(21):1933–43.

    PubMed  Google Scholar 

  11. Sanderson JE. Echocardiography for cardiac resynchronization therapy selection: fatally flawed or misjudged? J Am Coll Cardiol. 2009;53(21):1960–4.

    PubMed  Google Scholar 

  12. Spragg DD, Kass DA. Pathobiology of left ventricular dyssynchrony and resynchronization. Prog Cardiovasc Dis. 2006;49(1):26–41.

    PubMed  Google Scholar 

  13. Kanzaki H, Bazaz R, Schwartzman D, Dohi K, Sade LE, Gorcsan 3rd J. A mechanism for immediate reduction in mitral regurgitation after cardiac resynchronization therapy: insights from mechanical activation strain mapping. J Am Coll Cardiol. 2004;44(8):1619–25.

    PubMed  Google Scholar 

  14. Sanders P, Morton JB, Davidson NC, Spence SJ, Vohra JK, Sparks PB, Kalman JM. Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans. Circulation. 2003;108(12):1461–8.

    PubMed  Google Scholar 

  15. Van Beeumen K, Duytschaever M, Tavernier R, Van de Veire N, De Sutter J. Intra- and interatrial asynchrony in patients with heart failure. Am J Cardiol. 2007;99(1):79–83.

    PubMed  Google Scholar 

  16. Brecker SJ, Xiao HB, Sparrow J, Gibson DG. Effects of dual-chamber pacing with short atrioventricular delay in dilated cardiomyopathy. Lancet. 1992;340(8831):1308–12.

    CAS  PubMed  Google Scholar 

  17. Schoeller R, Andresen D, Büttner P, Oezcelik K, Vey G, Schröder R. First- or second-degree atrioventricular block as a risk factor in idiopathic dilated cardiomyopathy. Am J Cardiol. 1993;71(8):720–6.

    CAS  PubMed  Google Scholar 

  18. Nishimura RA, Hayes DL, Holmes Jr DR, Tajik AJ. Mechanism of hemodynamic improvement by dual-chamber pacing for severe left ventricular dysfunction: an acute Doppler and catheterization hemodynamic study. J Am Coll Cardiol. 1995;25(2):281–8.

    CAS  PubMed  Google Scholar 

  19. Panidis IP, Ross J, Munley B, Nestico P, Mintz GS. Diastolic mitral regurgitation in patients with atrioventricular conduction abnormalities: a common finding by Doppler echocardiography. J Am Coll Cardiol. 1986;7(4):768–74.

    CAS  PubMed  Google Scholar 

  20. Xiao HB, Lee CH, Gibson DG. Effect of left bundle branch block on diastolic function in dilated cardiomyopathy. Br Heart J. 1991;66(6):443–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  21. Auricchio A, Fantoni C, Steinberg JS. Acute and chronic sequelae of ventricular dyssynchrony. Prog Cardiovasc Dis. 2006;48(4):227–31.

    PubMed  Google Scholar 

  22. Hawkins NM, Petrie MC, MacDonald MR, Hogg KJ, McMurray JJ. Selecting patients for cardiac resynchronization therapy: electrical or mechanical dyssynchrony? Eur Heart J. 2006;27(11):1270–81.

    PubMed  Google Scholar 

  23. Auricchio A, Salo RW. Acute hemodynamic improvement by pacing in patients with severe congestive heart failure. Pacing Clin Electrophysiol. 1997;20:313–24.

    CAS  PubMed  Google Scholar 

  24. Hirschfeld S, Meyer R, Schwartz DC, Korfhagen J, Kaplan S. Measurement of right and left ventricular systolic time intervals by echocardiography. Circulation. 1975;51(2):304–9.

    CAS  PubMed  Google Scholar 

  25. Bordachar P, Garrigue S, Lafitte S, Reuter S, Jaïs P, Haïssaguerre M, Clementy J. Interventricular and intra-left ventricular electromechanical delays in right ventricular paced patients with heart failure: implications for upgrading to biventricular stimulation. Heart. 2003;89(12):1401–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  26. Houthuizen P, Bracke FA, van Gelder BM. Atrioventricular and interventricular delay optimization in cardiac resynchronization therapy: physiological principles and overview of available methods. Heart Fail Rev. 2011;16(3):263–76.

    PubMed Central  PubMed  Google Scholar 

  27. Weber KT, Janicki JS, Shroff S, Fishman AP. Contractile mechanics and interaction of the right and left ventricles. Am J Cardiol. 1981;47(3):686–95.

    CAS  PubMed  Google Scholar 

  28. Perego GB, Chianca R, Facchini M, Frattola A, Balla E, Zucchi S, Cavaglià S, Vicini I, Negretto M, Osculati G. Simultaneous vs. sequential biventricular pacing in dilated cardiomyopathy: an acute hemodynamic study. Eur J Heart Fail. 2003;5(3):305–13.

    PubMed  Google Scholar 

  29. Prinzen FW, Augustijn CH, Arts T, Allessie MA, Reneman RS. Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol. 1990;259(2 Pt 2):H300–8.

    CAS  PubMed  Google Scholar 

  30. Leclercq C, Faris O, Tunin R, Johnson J, Kato R, Evans F, Spinelli J, Halperin H, McVeigh E, Kass DA. Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block. Circulation. 2002;106(14):1760–3.

    PubMed  Google Scholar 

  31. Turner MS, Bleasdale RA, Mumford CE, Frenneaux MP, Morris-Thurgood JA. Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration. Heart. 2004;90(5):502–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  32. European Heart Rhythm Association, European Society of Cardiology, Heart Rhythm Society, Heart Failure Society of America, American Society of Echocardiography, American Heart Association, European Association of Echocardiography, Heart Failure Association, Daubert JC, Saxon L, Adamson PB, Auricchio A, Berger RD, Beshai JF, Breithard O, Brignole M, Cleland J, Delurgio DB, Dickstein K, Exner DV, Gold M, Grimm RA, Hayes DL, Israel C, Leclercq C, Linde C, Lindenfeld J, Merkely B, Mont L, Murgatroyd F, Prinzen F, Saba SF, Shinbane JS, Singh J, Tang AS, Vardas PE, Wilkoff BL, Zamorano JL. EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Heart Rhythm. 2012;9(9):1524–76.

    PubMed  Google Scholar 

  33. Winfree AT. The electrical thresholds of ventricular myocardium. J Cardiovasc Electrophysiol. 1990;1:393–410.

    Google Scholar 

  34. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW. 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119(14):e391–479.

    PubMed  Google Scholar 

  35. Epstein AE, DiMarco JP, Ellenbogen KA, Estes 3rd NA, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO, Smith Jr SC, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Faxon DP, Halperin JL, Hiratzka LF, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW, American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices), American Association for Thoracic Surgery, Society of Thoracic Surgeons. ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation. 2002;117(21):e350–408.

    Google Scholar 

  36. Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, Gorcsan 3rd J, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu CM. Cardiac resynchronization therapy: part 1–issues before device implantation. J Am Coll Cardiol. 2005;46(12):2153–67.

    PubMed  Google Scholar 

  37. Kerwin WF, Botvinick EH, O’Connell JW, Merrick SH, DeMarco T, Chatterjee K, Scheibly K, Saxon LA. Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony. J Am Coll Cardiol. 2000;35(5):1221–7.

    CAS  PubMed  Google Scholar 

  38. Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L, Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352(15):1539–49.

    CAS  PubMed  Google Scholar 

  39. St John Sutton MG, Plappert T, Abraham WT, Smith AL, DeLurgio DB, Leon AR, Loh E, Kocovic DZ, Fisher WG, Ellestad M, Messenger J, Kruger K, Hilpisch KE, Hill MR, Multicenter InSync Randomized Clinical Evaluation (MIRACLE) Study Group. Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure. Circulation. 2003;107(15):1985–90.

    PubMed  Google Scholar 

  40. Auricchio A, Abraham WT. Cardiac resynchronization therapy: current state of the art: cost versus benefit. Circulation. 2004;109(3):300–7.

    PubMed  Google Scholar 

  41. Leclercq C, Hare JM. Ventricular resynchronization: current state of the art. Circulation. 2004;109(3):296–9.

    PubMed  Google Scholar 

  42. Saxon LA, De Marco T, Schafer J, Chatterjee K, Kumar UN, Foster E, VIGOR Congestive Heart Failure Investigators. Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling. Circulation. 2002;105(11):1304–10.

    PubMed  Google Scholar 

  43. Yu CM, Chau E, Sanderson JE, Fan K, Tang MO, Fung WH, Lin H, Kong SL, Lam YM, Hill MR, Lau CP. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation. 2002;105(4):438–45.

    PubMed  Google Scholar 

  44. Sutton MG, Plappert T, Hilpisch KE, Abraham WT, Hayes DL, Chinchoy E. Sustained reverse left ventricular structural remodeling with cardiac resynchronization at one year is a function of etiology: quantitative Doppler echocardiographic evidence from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE). Circulation. 2006;113(2):266–72.

    PubMed  Google Scholar 

  45. Donal E, Leclercq C, Linde C, Daubert JC. Effects of cardiac resynchronization therapy on disease progression in chronic heart failure. Eur Heart J. 2006;27(9):1018–25.

    PubMed  Google Scholar 

  46. Zhang Q, Fung JW, Auricchio A, Chan JY, Kum LC, Wu LW, Yu CM. Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure. Eur Heart J. 2006;27(12):1423–30.

    PubMed  Google Scholar 

  47. Bleeker GB, Mollema SA, Holman ER, Van de Veire N, Ypenburg C, Boersma E, van der Wall EE, Schalij MJ, Bax JJ. Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline. Circulation. 2007;116(13):1440–8.

    PubMed  Google Scholar 

  48. Chakir K, Daya SK, Tunin RS, Helm RH, Byrne MJ, Dimaano VL, Lardo AC, Abraham TP, Tomaselli GF, Kass DA. Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization. Circulation. 2008;117(11):1369–77.

    PubMed  Google Scholar 

  49. Gheorghiade M, Bonow RO. Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation. 1998;97(3):282–9.

    CAS  PubMed  Google Scholar 

  50. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J, MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346(24):1845–53.

    PubMed  Google Scholar 

  51. Bradley DJ, Bradley EA, Baughman KL, Berger RD, Calkins H, Goodman SN, Kass DA, Powe NR. Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials. JAMA. 2003;289(6):730–40.

    PubMed  Google Scholar 

  52. Bleeker GB, Schalij MJ, Van Der Wall EE, Bax JJ. Postero-lateral scar tissue resulting in non-response to cardiac resynchronization therapy. J Cardiovasc Electrophysiol. 2006;17(8):899–901.

    PubMed  Google Scholar 

  53. Bleeker GB, Kaandorp TA, Lamb HJ, Boersma E, Steendijk P, de Roos A, van der Wall EE, Schalij MJ, Bax JJ. Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation. 2006;113(7):969–76.

    PubMed  Google Scholar 

  54. Ypenburg C, Schalij MJ, Bleeker GB, Steendijk P, Boersma E, Dibbets-Schneider P, Stokkel MP, van der Wall EE, Bax JJ. Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients. Eur Heart J. 2007;28(1):33–41.

    PubMed  Google Scholar 

  55. Ypenburg C, van Bommel RJ, Delgado V, Mollema SA, Bleeker GB, Boersma E, Schalij MJ, Bax JJ. Optimal left ventricular lead position predicts reverse remodeling and survival after cardiac resynchronization therapy. J Am Coll Cardiol. 2008;52(17):1402–9.

    PubMed  Google Scholar 

  56. Fung JW, Lam YY, Zhang Q, Yip GW, Chan WW, Chan GC, Chan JY, Yu CM. Effect of left ventricular lead concordance to the delayed contraction segment on echocardiographic and clinical outcomes after cardiac resynchronization therapy. J Cardiovasc Electrophysiol. 2009;20(5):530–5.

    PubMed  Google Scholar 

  57. Becker M, Hoffmann R, Schmitz F, Hundemer A, Kühl H, Schauerte P, Kelm M, Franke A. Relation of optimal lead positioning as defined by three-dimensional echocardiography to long-term benefit of cardiac resynchronization. Am J Cardiol. 2007;100(11):1671–6.

    PubMed  Google Scholar 

  58. Bax JJ, Bleeker GB, Marwick TH, Molhoek SG, Boersma E, Steendijk P, van der Wall EE, Schalij MJ. Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy. J Am Coll Cardiol. 2004;44(9):1834–40.

    PubMed  Google Scholar 

  59. Ypenburg C, van Bommel RJ, Borleffs CJ, Bleeker GB, Boersma E, Schalij MJ, Bax JJ. Long-term prognosis after cardiac resynchronization therapy is related to the extent of left ventricular reverse remodeling at midterm follow-up. J Am Coll Cardiol. 2009;53(6):483–90.

    PubMed  Google Scholar 

  60. Mangiavacchi M, Gasparini M, Faletra F, Klersy C, Morenghi E, Galimberti P, Genovese L, Regoli F, De Chiara F, Bragato R, Andreuzzi B, Pini D, Gronda E. Clinical predictors of marked improvement in left ventricular performance after cardiac resynchronization therapy in patients with chronic heart failure. Am Heart J. 2006;151(2):477.e1–6.

    Google Scholar 

  61. Anand IS, Florea VG, Fisher L. Surrogate end points in heart failure. J Am Coll Cardiol. 2002;39(9):1414–21.

    PubMed  Google Scholar 

  62. Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, Abraham WT, Ghio S, Leclercq C, Bax JJ, Yu CM, Gorcsan 3rd J, St John Sutton M, De Sutter J, Murillo J. Results of the predictors of response to CRT (PROSPECT) trial. Circulation. 2008;117(20):2608–16.

    PubMed  Google Scholar 

  63. Ansalone G, Giannantoni P, Ricci R, Trambaiolo P, Fedele F, Santini M. Biventricular pacing in heart failure: back to basics in the pathophysiology of left bundle branch block to reduce the number of nonresponders. Am J Cardiol. 2003;91(9A):55F–61.

    PubMed  Google Scholar 

  64. Emkanjoo Z, Esmaeilzadeh M, Mohammad Hadi N, Alizadeh A, Tayyebi M, Sadr-Ameli MA. Frequency of inter- and intraventricular dyssynchrony in patients with heart failure according to QRS width. Europace. 2007;9(12):1171–6.

    PubMed  Google Scholar 

  65. Ginks MR, Sciaraffia E, Karlsson A, Gustafsson J, Hamid S, Bostock J, Simon M, Blomström-Lundqvist C, Rinaldi CA. Relationship between intracardiac impedance and left ventricular contractility in patients undergoing cardiac resynchronization therapy. Europace. 2011;13(7):984–91.

    PubMed Central  PubMed  Google Scholar 

  66. Cazeau S, Leclercq C, Lavergne T, Walker S, Varma C, Linde C, Garrigue S, Kappenberger L, Haywood GA, Santini M, Bailleul C, Daubert JC, Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001;344(12):873–80.

    CAS  PubMed  Google Scholar 

  67. Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, DeMets D, White BG, DeVries DW, Feldman AM, Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350(21):2140–50.

    CAS  PubMed  Google Scholar 

  68. Strickberger SA, Conti J, Daoud EG, Havranek E, Mehra MR, Piña IL, Young J, Council on Clinical Cardiology Subcommittee on Electrocardiography and Arrhythmias and the Quality of Care and Outcomes Research Interdisciplinary Working Group, Heart Rhythm Society. Patient selection for cardiac resynchronization therapy: from the Council on Clinical Cardiology Subcommittee on Electrocardiography and Arrhythmias and the Quality of Care and Outcomes Research Interdisciplinary Working Group, in collaboration with the Heart Rhythm Society. Circulation. 2005;111(16):2146–50.

    PubMed  Google Scholar 

  69. Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, Tavazzi L, Smiseth OA, Gavazzi A, Haverich A, Hoes A, Jaarsma T, Korewicki J, Lévy S, Linde C, Lopez-Sendon JL, Nieminen MS, Piérard L, Remme WJ, Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J. 2005;26(11):1115–40.

    PubMed  Google Scholar 

  70. Bleeker GB, Schalij MJ, Molhoek SG, Verwey HF, Holman ER, Boersma E, Steendijk P, Van Der Wall EE, Bax JJ. Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure. J Cardiovasc Electrophysiol. 2004;15(5):544–9.

    PubMed  Google Scholar 

  71. Yu CM, Lin H, Zhang Q, Sanderson JE. High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart. 2003;89(1):54–60.

    PubMed Central  PubMed  Google Scholar 

  72. Bleeker GB, Schalij MJ, Molhoek SG, Holman ER, Verwey HF, Steendijk P, van der Wall EE, Bax JJ. Frequency of left ventricular dyssynchrony in patients with heart failure and a narrow QRS complex. Am J Cardiol. 2005;95(1):140–2.

    PubMed  Google Scholar 

  73. Rouleau F, Merheb M, Geffroy S, Berthelot J, Chaleil D, Dupuis JM, Victor J, Geslin P. Echocardiographic assessment of the interventricular delay of activation and correlation to the QRS width in dilated cardiomyopathy. Pacing Clin Electrophysiol. 2001;24(10):1500–6.

    CAS  PubMed  Google Scholar 

  74. Ghio S, Constantin C, Klersy C, Serio A, Fontana A, Campana C, Tavazzi L. Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J. 2004;25(7):571–8.

    PubMed  Google Scholar 

  75. Dickstein K, Vardas PE, Auricchio A, Daubert JC, Linde C, McMurray J, Ponikowski P, Priori SG, Sutton R, van Veldhuisen DJ, ESC Committee for Practice Guidelines. 2010 focused update of ESC guidelines on device therapy in heart failure: an update of the 2008 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Europace. 2010;12(11):1526–36.

    PubMed  Google Scholar 

  76. Auricchio A, Stellbrink C, Butter C, Sack S, Vogt J, Misier AR, Böcker D, Block M, Kirkels JH, Kramer A, Huvelle E, Pacing Therapies in Congestive Heart Failure II Study Group; Guidant Heart Failure Research Group. Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay. J Am Coll Cardiol. 2003;42(12):2109–16.

    PubMed  Google Scholar 

  77. Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes 3rd NA, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W, MADIT-CRT Trial Investigators. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009;361(14):1329–38.

    PubMed  Google Scholar 

  78. Linde C, Abraham WT, Gold MR, Daubert C, REVERSE Study Group. Cardiac resynchronization therapy in asymptomatic or mildly symptomatic heart failure patients in relation to etiology: results from the REVERSE (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction) study. J Am Coll Cardiol. 2010;56(22):1826–31.

    PubMed  Google Scholar 

  79. Perez de Isla L, Florit J, Garcia-Fernandez MA, Evangelista A, Zamorano J, RAVE (Registro de Asincronía Ventricular en España-Spanish Ventricular Asynchrony Registry) study investigators. Prevalence of echocardiographically detected ventricular asynchrony in patients with left ventricular systolic dysfunction. J Am Soc Echocardiogr. 2005;18(8):850–9.

    PubMed  Google Scholar 

  80. Ho KK, Anderson KM, Kannel WB, Grossman W, Levy D. Survival after the onset of congestive heart failure in Framingham heart study subjects. Circulation. 1993;88(1):107–15.

    CAS  PubMed  Google Scholar 

  81. Curry CW, Nelson GS, Wyman BT, Declerck J, Talbot M, Berger RD, McVeigh ER, Kass DA. Mechanical dyssynchrony in dilated cardiomyopathy with intraventricular conduction delay as depicted by 3D tagged magnetic resonance imaging. Circulation. 2000;101(1):E2.

    CAS  PubMed  Google Scholar 

  82. Fauchier L, Marie O, Casset-Senon D, Babuty D, Cosnay P, Fauchier JP. Reliability of QRS duration and morphology on surface electrocardiogram to identify ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy. Am J Cardiol. 2003;92(3):341–4.

    PubMed  Google Scholar 

  83. Bertini M, Delgado V, Bax JJ, Van de Veire NR. Why, how and when do we need to optimize the setting of cardiac resynchronization therapy? Europace. 2009;11 Suppl 5:v46–57.

    PubMed  Google Scholar 

  84. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW, Antman EM, Smith Jr SC, Adams CD, Anderson JL, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B, American College of Cardiology, American Heart Association Task Force on Practice Guidelines, American College of Chest Physicians, International Society for Heart and Lung Transplantation, Heart Rhythm Society. Guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation. 2005;112(12):e154–235.

    PubMed  Google Scholar 

  85. Bleeker GB, Yu CM, Nihoyannopoulos P, de Sutter J, Van de Veire N, Holman ER, Schalij MJ, van der Wall EE, Bax JJ. Optimal use of echocardiography in cardiac resynchronisation therapy. Heart. 2007;93(11):1339–50.

    PubMed Central  PubMed  Google Scholar 

  86. Yu CM, Bax JJ, Monaghan M, Nihoyannopoulos P. Echocardiographic evaluation of cardiac dyssynchrony for predicting a favourable response to cardiac resynchronisation therapy. Heart. 2004;90 Suppl 6:vi17–22.

    PubMed Central  PubMed  Google Scholar 

  87. Waggoner AD, Agler DA, Adams DB. Cardiac resynchronization therapy and the emerging role of echocardiography (part 1): indications and results from current studies. J Am Soc Echocardiogr. 2007;20(1):70–5.

    PubMed  Google Scholar 

  88. Agler DA, Adams DB, Waggoner AD. Cardiac resynchronization therapy and the emerging role of echocardiography (part 2): the comprehensive examination. J Am Soc Echocardiogr. 2007;20(1):76–90.

    PubMed  Google Scholar 

  89. Gorcsan 3rd J, Abraham T, Agler DA, Bax JJ, Derumeaux G, Grimm RA, Martin R, Steinberg JS, Sutton MS, Yu CM, American Society of Echocardiography Dyssynchrony Writing Group. Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting–a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society. J Am Soc Echocardiogr. 2008;21(3):191–213.

    PubMed  Google Scholar 

  90. Bonita A. Echocardiography: the normal examination and echocardiographic measurements. Second edition. MGA Graphics; 2007. ISBN 9780646468631.

    Google Scholar 

  91. Pitzalis MV, Iacoviello M, Romito R, Massari F, Rizzon B, Luzzi G, Guida P, Andriani A, Mastropasqua F, Rizzon P. Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony. J Am Coll Cardiol. 2002;40(9):1615–22.

    PubMed  Google Scholar 

  92. Marcus GM, Rose E, Viloria EM, Schafer J, De Marco T, Saxon LA, Foster E, VENTAK CHF/CONTAK-CD Biventricular Pacing Study Investigators. Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol. 2005;46(12):2208–14.

    PubMed  Google Scholar 

  93. Sassone B, Capecchi A, Boggian G, Gabrieli L, Saccà S, Vandelli R, Petracci E, Mele D. Value of baseline left lateral wall postsystolic displacement assessed by M-mode to predict reverse remodeling by cardiac resynchronization therapy. Am J Cardiol. 2007;100(3):470–5.

    PubMed  Google Scholar 

  94. Kukulski T, Hubbert L, Arnold M, Wranne B, Hatle L, Sutherland GR. Normal regional right ventricular function and its change with age: a Doppler myocardial imaging study. J Am Soc Echocardiogr. 2000;13(3):194–204.

    CAS  PubMed  Google Scholar 

  95. Waggoner AD, Bierig SM. Tissue Doppler imaging: a useful echocardiographic method for the cardiac sonographer to assess systolic and diastolic ventricular function. J Am Soc Echocardiogr. 2001;14(12):1143–52.

    CAS  PubMed  Google Scholar 

  96. Gorcsan 3rd J, Kanzaki H, Bazaz R, Dohi K, Schwartzman D. Usefulness of echocardiographic tissue synchronization imaging to predict acute response to cardiac resynchronization therapy. Am J Cardiol. 2004;93(9):1178–81.

    PubMed  Google Scholar 

  97. Yu CM, Zhang Q, Fung JW, Chan HC, Chan YS, Yip GW, Kong SL, Lin H, Zhang Y, Sanderson JE. A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging. J Am Coll Cardiol. 2005;45(5):677–84.

    PubMed  Google Scholar 

  98. Sengupta PP, Korinek J, Belohlavek M, Narula J, Vannan MA, Jahangir A, Khandheria BK. Left ventricular structure and function: basic science for cardiac imaging. J Am Coll Cardiol. 2006;48(10):1988–2001.

    PubMed  Google Scholar 

  99. Bijnens BH, Cikes M, Claus P, Sutherland GR. Velocity and deformation imaging for the assessment of myocardial dysfunction. Eur J Echocardiogr. 2009;10(2):216–26.

    PubMed  Google Scholar 

  100. Mirsky I, Parmley WW. Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circ Res. 1973;33(2):233–43.

    CAS  PubMed  Google Scholar 

  101. Abraham TP, Dimaano VL, Liang HY. Role of tissue Doppler and strain echocardiography in current clinical practice. Circulation. 2007;116(22):2597–609.

    PubMed  Google Scholar 

  102. Sun JP, Popović ZB, Greenberg NL, Xu XF, Asher CR, Stewart WJ, Thomas JD. Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging. J Am Soc Echocardiogr. 2004;17(2):132–8.

    PubMed  Google Scholar 

  103. Urheim S, Edvardsen T, Torp H, Angelsen B, Smiseth OA. Myocardial strain by Doppler echocardiography. Validation of a new method to quantify regional myocardial function. Circulation. 2000;102(10):1158–64.

    CAS  PubMed  Google Scholar 

  104. Helle-Valle T, Crosby J, Edvardsen T, Lyseggen E, Amundsen BH, Smith HJ, Rosen BD, Lima JA, Torp H, Ihlen H, Smiseth OA. New noninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography. Circulation. 2005;112(20):3149–56.

    PubMed  Google Scholar 

  105. Notomi Y, Lysyansky P, Setser RM, Shiota T, Popović ZB, Martin-Miklovic MG, Weaver JA, Oryszak SJ, Greenberg NL, White RD, Thomas JD. Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging. J Am Coll Cardiol. 2005;45(12):2034–41.

    PubMed  Google Scholar 

  106. Leitman M, Lysyansky P, Sidenko S, Shir V, Peleg E, Binenbaum M, Kaluski E, Krakover R, Vered Z. Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr. 2004;17(10):1021–9.

    PubMed  Google Scholar 

  107. Becker M, Hoffmann R, Kühl HP, Grawe H, Katoh M, Kramann R, Bücker A, Hanrath P, Heussen N. Analysis of myocardial deformation based on ultrasonic pixel tracking to determine transmurality in chronic myocardial infarction. Eur Heart J. 2006;27(21):2560–6.

    PubMed  Google Scholar 

  108. Chan J, Hanekom L, Wong C, Leano R, Cho GY, Marwick TH. Differentiation of subendocardial and transmural infarction using two-dimensional strain rate imaging to assess short-axis and long-axis myocardial function. J Am Coll Cardiol. 2006;48(10):2026–33.

    PubMed  Google Scholar 

  109. Gjesdal O, Hopp E, Vartdal T, Lunde K, Helle-Valle T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T. Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease. Clin Sci (Lond). 2007;113(6):287–96.

    Google Scholar 

  110. Goffinet C, Chenot F, Robert A, Pouleur AC, le Polain de Waroux JB, Vancrayenest D, Gerard O, Pasquet A, Gerber BL, Vanoverschelde JL. Assessment of subendocardial vs. subepicardial left ventricular rotation and twist using two-dimensional speckle tracking echocardiography: comparison with tagged cardiac magnetic resonance. Eur Heart J. 2009;30(5):608–17.

    PubMed  Google Scholar 

  111. Suffoletto MS, Dohi K, Cannesson M, Saba S, Gorcsan 3rd J. Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy. Circulation. 2006;113(7):960–8.

    PubMed  Google Scholar 

  112. Sugeng L, Weinert L, Lang RM. Left ventricular assessment using real time three dimensional echocardiography. Heart. 2003;89 Suppl 3:iii29–36.

    PubMed Central  PubMed  Google Scholar 

  113. Jenkins C, Bricknell K, Hanekom L, Marwick TH. Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography. J Am Coll Cardiol. 2004;44(4):878–86.

    PubMed  Google Scholar 

  114. Sugeng L, Mor-Avi V, Weinert L, Niel J, Ebner C, Steringer-Mascherbauer R, Schmidt F, Galuschky C, Schummers G, Lang RM, Nesser HJ. Quantitative assessment of left ventricular size and function: side-by-side comparison of real-time three-dimensional echocardiography and computed tomography with magnetic resonance reference. Circulation. 2006;114(7):654–61.

    PubMed  Google Scholar 

  115. Anderson LJ, Miyazaki C, Sutherland GR, Oh JK. Patient selection and echocardiographic assessment of dyssynchrony in cardiac resynchronization therapy. Circulation. 2008;117(15):2009–23.

    PubMed  Google Scholar 

  116. Oh JK, Hatle L, Tajik AJ, Little WC. Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography. J Am Coll Cardiol. 2006;47(3):500–6.

    PubMed  Google Scholar 

  117. Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Klein W, Tavazzi L, CARE-HF study Steering Committee and Investigators. The CARE-HF study (CArdiac REsynchronisation in Heart Failure study): rationale, design and end-points. Eur J Heart Fail. 2001;3(4):481–9.

    CAS  PubMed  Google Scholar 

  118. Ritter P, Dib JC, Mahaux V, Lelièvre T, Soyeur D, Lavergne T, Cazeau S, Guize L, Rabine LM, Daubert JC. New method for determining the optimal atrio-ventricular delay in patients paced in DDD mode for complete atrio-ventricular block (abstract). Pacing Clin Electrophysiol. 1995;18:855.

    Google Scholar 

  119. Kerlan JE, Sawhney NS, Waggoner AD, Chawla MK, Garhwal S, Osborn JL, Faddis MN. Prospective comparison of echocardiographic atrioventricular delay optimization methods for cardiac resynchronization therapy. Heart Rhythm. 2006;3(2):148–54.

    PubMed  Google Scholar 

  120. Ritter P, Lelieve T, Lavergne T. Quick determination of the optimal AV delay at rest in patients paced in DDD mode for complete AV block. Eur J Cardiac Pacing Electrophysiol. 1994;4:P54.

    Google Scholar 

  121. Kindermann M, Fröhlig G, Doerr T, Schieffer H. Optimizing the AV delay in DDD pacemaker patients with high degree AV block: mitral valve Doppler versus impedance cardiography. Pacing Clin Electrophysiol. 1997;20(10 Pt 1):2453–62.

    CAS  PubMed  Google Scholar 

  122. Dupuis JM, Kobeissi A, Vitali L, Gaggini G, Merheb M, Rouleau F, Leftheriotis G, Ritter P, Victor J. Programming optimal atrioventricular delay in dual chamber pacing using peak endocardial acceleration: comparison with a standard echocardiographic procedure. Pacing Clin Electrophysiol. 2003;26(1 Pt 2):210–3.

    PubMed  Google Scholar 

  123. León AR, Abraham WT, Brozena S, Daubert JP, Fisher WG, Gurley JC, Liang CS, Wong G, InSync III Clinical Study Investigators. Cardiac resynchronization with sequential biventricular pacing for the treatment of moderate-to-severe heart failure. J Am Coll Cardiol. 2005;46(12):2298–304.

    PubMed  Google Scholar 

  124. Ritter P, Padeletti L, Gillio-Meina L, Gaggini G. Determination of the optimal atrioventricular delay in DDD pacing. Comparison between echo and peak endocardial acceleration measurements. Europace. 1999;1(2):126–30.

    CAS  PubMed  Google Scholar 

  125. Burri H, Sunthorn H, Shah D, Lerch R. Optimization of device programming for cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2006;29(12):1416–25.

    PubMed  Google Scholar 

  126. Barold SS, Ilercil A, Herweg B. Echocardiographic optimization of the atrioventricular and interventricular intervals during cardiac resynchronization. Europace. 2008;10 Suppl 3:iii88–95.

    PubMed  Google Scholar 

  127. Jansen AH, Bracke FA, van Dantzig JM, Meijer A, van der Voort PH, Aarnoudse W, van Gelder BM, Peels KH. Correlation of echo-Doppler optimization of atrioventricular delay in cardiac resynchronization therapy with invasive hemodynamics in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2006;97(4):552–7.

    PubMed  Google Scholar 

  128. Gold MR, Niazi I, Giudici M, Leman RB, Sturdivant JL, Kim MH, Yu Y, Ding J, Waggoner AD. A prospective comparison of AV delays programming methods for hemodynamic optimization during cardiac resynchronization therapy. J Cardiovasc Electrophysiol. 2007;18(5):490–6.

    PubMed  Google Scholar 

  129. Meluzín J, Novák M, Müllerová J, Krejcí J, Hude P, Eisenberger M, Dusek L, Dvorák I, Spinarová L. A fast and simple echocardiographic method of determination of the optimal atrioventricular delay in patients after biventricular stimulation. Pacing Clin Electrophysiol. 2004;27(1):58–64.

    PubMed  Google Scholar 

  130. Bordachar P, Lafitte S, Reuter S, Sanders P, Jaïs P, Haïssaguerre M, Roudaut R, Garrigue S, Clementy J. Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing. J Am Coll Cardiol. 2004;44(11):2157–65.

    PubMed  Google Scholar 

  131. Mortensen PT, Sogaard P, Mansour H, Ponsonaille J, Gras D, Lazarus A, Reiser W, Alonso C, Linde CM, Lunati M, Kramm B, Harrison EM. Sequential biventricular pacing: evaluation of safety and efficacy. Pacing Clin Electrophysiol. 2004;27(3):339–45.

    PubMed  Google Scholar 

  132. Porciani MC, Dondina C, Macioce R, Demarchi G, Pieragnoli P, Musilli N, Colella A, Ricciardi G, Michelucci A, Padeletti L. Echocardiographic examination of atrioventricular and interventricular delay optimization in cardiac resynchronization therapy. Am J Cardiol. 2005;95(9):1108–10.

    PubMed  Google Scholar 

  133. Riedlbauchová L, Kautzner J, Frídl P. Influence of different atrioventricular and interventricular delays on cardiac output during cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2005;28 Suppl 1:S19–23.

    PubMed  Google Scholar 

  134. Vanderheyden M, De Backer T, Rivero-Ayerza M, Geelen P, Bartunek J, Verstreken S, De Zutter M, Goethals M. Tailored echocardiographic interventricular delay programming further optimizes left ventricular performance after cardiac resynchronization therapy. Heart Rhythm. 2005;2(10):1066–72.

    PubMed  Google Scholar 

  135. Boriani G, Müller CP, Seidl KH, Grove R, Vogt J, Danschel W, Schuchert A, Djiane P, Biffi M, Becker T, Bailleul C, Trappe HJ, Resynchronization for the HemodYnamic Treatment for Heart Failure Management II Investigators. Randomized comparison of simultaneous biventricular stimulation versus optimized interventricular delay in cardiac resynchronization therapy. The Resynchronization for the HemodYnamic Treatment for Heart Failure Management II implantable cardioverter defibrillator (RHYTHM II ICD) study. Am Heart J. 2006;151(5):1050–8.

    PubMed  Google Scholar 

  136. Ishikawa T, Sumita S, Kimura K, Kuji N, Nakayama R, Nagura T, Miyazaki N, Tochikubo O, Usui T, Kashiwagi M, et al. Critical PQ interval for the appearance of diastolic mitral regurgitation and optimal PQ interval in patients implanted with DDD pacemakers. Pacing Clin Electrophysiol. 1994;17(11 Pt 2):1989–94.

    CAS  PubMed  Google Scholar 

  137. Ishikawa T, Sumita S, Kimura K, Kikuchi M, Kosuge M, Kuji N, Endo T, Sugano T, Sigemasa T, Kobayashi I, Tochikubo O, Usui T. Prediction of optimal atrioventricular delay in patients with implanted DDD pacemakers. Pacing Clin Electrophysiol. 1999;22(9):1365–71.

    CAS  PubMed  Google Scholar 

  138. Ishikawa T, Sumita S, Kimura K, Kikuchi M, Kosuge M, Nakagawa T, Matsushita K, Usui T, Umemura S. Efficacy of atrioventricular sequential pacing and diastolic mitral regurgitation in patients with intrinsic atrioventricular conduction. Jpn Circ J. 2000;64(8):579–82.

    CAS  PubMed  Google Scholar 

  139. Inoue N, Ishikawa T, Sumita S, Nakagawa T, Kobayashi T, Matsushita K, Matsumoto K, Ohkusu Y, Taima M, Kosuge M, Uchino K, Kimura K, Umemura S. Long-term follow-up of atrioventricular delay optimization in patients with biventricular pacing. Circ J. 2005;69(2):201–4.

    PubMed  Google Scholar 

  140. Ishikawa T, Kimura K, Nihei T, Usui T, Kashiwagi M, Ishii M. Relationship between diastolic mitral regurgitation and PQ intervals or cardiac function in patients implanted with DDD pacemakers. Pacing Clin Electrophysiol. 1991;14(11 Pt 2):1797–802.

    CAS  PubMed  Google Scholar 

  141. Melzer C, Knebel F, Ismer B, Bondke H, Nienaber CA, Baumann G, Borges AC. Influence of the atrio-ventricular delay optimization on the intra left ventricular delay in cardiac resynchronization therapy. Cardiovasc Ultrasound. 2006;4:5.

    PubMed Central  PubMed  Google Scholar 

  142. Ismer B, von Knorre GH, Voß W, Körber T. Definition of the optimal atrioventricular delay by simultaneous measurement of electrocardiographic and Doppler-echocardiographic parameters. Prog Biomed Res. 2003;7:116–20.

    Google Scholar 

  143. Ismer B, Von Knorre GH, Voss W, Grille W, Klenke G, Pulya K, Koglek W, Suntinger A, Luessow H. Exercise induced sympathetic influences do not change interatrial conduction times in VDD and DDD pacing. Pacing Clin Electrophysiol. 1996;19(11 Pt 2):1786–90.

    CAS  PubMed  Google Scholar 

  144. Ypenburg C, Van De Veire N, Westenberg JJ, Bleeker GB, Marsan NA, Henneman MM, Van Der Wall EE, Schalij MJ, Abraham TP, Barold SS, Bax JJ. Noninvasive imaging in cardiac resynchronization therapy–part 2: follow-up and optimization of settings. Pacing Clin Electrophysiol. 2008;31(12):1628–39.

    PubMed  Google Scholar 

  145. Sawhney NS, Waggoner AD, Garhwal S, Chawla MK, Osborn J, Faddis MN. Randomized prospective trial of atrioventricular delay programming for cardiac resynchronization therapy. Heart Rhythm. 2004;1(5):562–7.

    PubMed  Google Scholar 

  146. Goldman JH, Schiller NB, Lim DC, Redberg RF, Foster E. Usefulness of stroke distance by echocardiography as a surrogate marker of cardiac output that is independent of gender and size in a normal population. Am J Cardiol. 2001;87(4):499–502, A8.

    CAS  PubMed  Google Scholar 

  147. Coats AJ. Doppler ultrasonic measurement of cardiac output: reproducibility and validation. Eur Heart J. 1990;11(Suppl I):49–61.

    PubMed  Google Scholar 

  148. Dubin J, Wallerson DC, Cody RJ, Devereux RB. Comparative accuracy of Doppler echocardiographic methods for clinical stroke volume determination. Am Heart J. 1990;120(1):116–23.

    CAS  PubMed  Google Scholar 

  149. Gola A, Pozzoli M, Capomolla S, Traversi E, Sanarico M, Cobelli F, Tavazzi L. Comparison of Doppler echocardiography with thermodilution for assessing cardiac output in advanced congestive heart failure. Am J Cardiol. 1996;78(6):708–12.

    CAS  PubMed  Google Scholar 

  150. Harrison MR, Smith MD, Nissen SE, Grayburn PA, DeMaria AN. Use of exercise Doppler echocardiography to evaluate cardiac drugs: effects of propranolol and verapamil on aortic blood flow velocity and acceleration. J Am Coll Cardiol. 1988;11(5):1002–9.

    CAS  PubMed  Google Scholar 

  151. Wong M, Matsumura M, Omoto R. Left and right ventricular flows by Doppler echocardiography: serial measurements in patients with aortic regurgitation during exercise, cold pressor stimulation, and vasodilatation. J Am Soc Echocardiogr. 1990;3(4):285–93.

    CAS  PubMed  Google Scholar 

  152. Wish M, Fletcher RD, Gottdiener JS, Cohen AI. Importance of left atrial timing in the programming of dual-chamber pacemakers. Am J Cardiol. 1987;60(7):566–71.

    CAS  PubMed  Google Scholar 

  153. León AR, Abraham WT, Curtis AB, Daubert JP, Fisher WG, Gurley J, Hayes DL, Lieberman R, Petersen-Stejskal S, Wheelan K, MIRACLE Study Program. Safety of transvenous cardiac resynchronization system implantation in patients with chronic heart failure: combined results of over 2,000 patients from a multicenter study program. J Am Coll Cardiol. 2005;46(12):2348–56.

    PubMed  Google Scholar 

  154. Dohi K, Suffoletto M, Ganz L, Zenati M, Gorcsan 3rd J. Utility of echocardiographic tissue synchronization imaging to redirect left ventricular lead placement for improved cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2005;28(5):461–5.

    PubMed  Google Scholar 

  155. Bleeker GB, Bax JJ, Schalij MJ, van der Wall EE. Tissue Doppler imaging to assess left ventricular dyssynchrony and resynchronization therapy. Eur J Echocardiogr. 2005;6(5):382–4.

    PubMed  Google Scholar 

  156. Vidal B, Sitges M, Marigliano A, Delgado V, Díaz-Infante E, Azqueta M, Tamborero D, Tolosana JM, Berruezo A, Pérez-Villa F, Paré C, Mont L, Brugada J. Optimizing the programation of cardiac resynchronization therapy devices in patients with heart failure and left bundle branch block. Am J Cardiol. 2007;100(6):1002–6.

    PubMed  Google Scholar 

  157. Novák M, Lipoldová J, Meluzín J, Krejcí J, Hude P, Feitová V, Dusek L, Kamarýt P, Vítovec J. Contribution to the V-V interval optimization in patients with cardiac resynchronization therapy. Physiol Res. 2008;57(5):693–700.

    PubMed  Google Scholar 

  158. Morales MA, Startari U, Panchetti L, Rossi A, Piacenti M. Atrioventricular delay optimization by Doppler-derived left ventricular dP/dt improves 6-month outcome of resynchronized patients. Pacing Clin Electrophysiol. 2006;29(6):564–8.

    PubMed  Google Scholar 

  159. Bargiggia GS, Bertucci C, Recusani F, Raisaro A, de Servi S, Valdes-Cruz LM, Sahn DJ, Tronconi L. A new method for estimating left ventricular dP/dt by continuous wave Doppler-echocardiography. Validation studies at cardiac catheterization. Circulation. 1989;80(5):1287–92.

    CAS  PubMed  Google Scholar 

  160. Chung N, Nishimura RA, Holmes Jr DR, Tajik AJ. Measurement of left ventricular dp/dt by simultaneous Doppler echocardiography and cardiac catheterization. J Am Soc Echocardiogr. 1992;5(2):147–52.

    CAS  PubMed  Google Scholar 

  161. Breithardt OA, Sinha AM, Schwammenthal E, Bidaoui N, Markus KU, Franke A, Stellbrink C. Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure. J Am Coll Cardiol. 2003;41(5):765–70.

    PubMed  Google Scholar 

  162. Thomas DE, Yousef ZR, Fraser AG. A critical comparison of echocardiographic measurements used for optimizing cardiac resynchronization therapy: stroke distance is best. Eur J Heart Fail. 2009;11(8):779–88.

    PubMed  Google Scholar 

  163. Tournoux FB, Alabiad C, Fan D, Chen AA, Chaput M, Heist EK, Mela T, Mansour M, Reddy V, Ruskin JN, Picard MH, Singh JP. Echocardiographic measures of acute haemodynamic response after cardiac resynchronization therapy predict long-term clinical outcome. Eur Heart J. 2007;28(9):1143–8.

    PubMed  Google Scholar 

  164. Tei C, Ling LH, Hodge DO, Bailey KR, Oh JK, Rodeheffer RJ, Tajik AJ, Seward JB. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function–a study in normals and dilated cardiomyopathy. J Cardiol. 1995;26(6):357–66.

    CAS  PubMed  Google Scholar 

  165. Tei C. New non-invasive index for combined systolic and diastolic ventricular function. J Cardiol. 1995;26(2):135–6.

    CAS  PubMed  Google Scholar 

  166. Porciani MC, Fantini F, Musilli N, Sabini A, Michelucci A, Colella A, Pieragnoli P, Demarchi G, Padeletti L. A perspective on atrioventricular delay optimization in patients with a dual chamber pacemaker. Pacing Clin Electrophysiol. 2004;27(3):333–8.

    Google Scholar 

  167. Yoshifuku S, Otsuji Y, Takasaki K, Yuge K, Kisanuki A, Toyonaga K, Lee S, Murayama T, Nakashima H, Kumanohoso T, Minagoe S, Tei C. Pseudonormalized Doppler total ejection isovolume (Tei) index in patients with right ventricular acute myocardial infarction. Am J Cardiol. 2003;91(5):527–31.

    PubMed  Google Scholar 

  168. Tham EB, Silverman NH. Measurement of the Tei index: a comparison of M-mode and pulse Doppler methods. J Am Soc Echocardiogr. 2004;17(12):1259–65.

    PubMed  Google Scholar 

  169. Rojo EC, Rodrigo JL, Pérez de Isla L, Almería C, Gonzalo N, Aubele A, Cinza R, Zamorano J, Macaya C. Disagreement between tissue Doppler imaging and conventional pulsed wave Doppler in the measurement of myocardial performance index. Eur J Echocardiogr. 2006;7(5):356–64.

    PubMed  Google Scholar 

  170. Tei C, Nishimura RA, Seward JB, Tajik AJ. Noninvasive Doppler-derived myocardial performance index: correlation with simultaneous measurements of cardiac catheterization measurements. J Am Soc Echocardiogr. 1997;10(2):169–78.

    CAS  PubMed  Google Scholar 

  171. Stockburger M, Fateh-Moghadam S, Nitardy A, Langreck H, Haverkamp W, Dietz R. Optimization of cardiac resynchronization guided by Doppler echocardiography: haemodynamic improvement and intraindividual variability with different pacing configurations and atrioventricular delays. Europace. 2006;8(10):881–6.

    PubMed  Google Scholar 

  172. Auricchio A, Stellbrink C, Sack S, Block M, Vogt J, Bakker P, Mortensen P, Klein H. The Pacing Therapies for Congestive Heart Failure (PATH-CHF) study: rationale, design, and endpoints of a prospective randomized multicenter study. Am J Cardiol. 1999;83(5B):130D–5.

    CAS  PubMed  Google Scholar 

  173. Nelson GS, Curry CW, Wyman BT, Kramer A, Declerck J, Talbot M, Douglas MR, Berger RD, McVeigh ER, Kass DA. Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay. Circulation. 2000;101(23):2703–9.

    CAS  PubMed  Google Scholar 

  174. Mason DT. Usefulness and limitations of the rate of rise of intraventricular pressure (dp-dt) in the evaluation of myocardial contractility in man. Am J Cardiol. 1969;23(4):516–27.

    CAS  PubMed  Google Scholar 

  175. Verbeek XA, Vernooy K, Peschar M, Van Der Nagel T, Van Hunnik A, Prinzen FW. Quantification of interventricular asynchrony during LBBB and ventricular pacing. Am J Physiol Heart Circ Physiol. 2002;283(4):H1370–8.

    CAS  PubMed  Google Scholar 

  176. Bogaard MD, Houthuizen P, Bracke FA, Doevendans PA, Prinzen FW, Meine M, van Gelder BM. Baseline left ventricular dP/dtmax rather than the acute improvement in dP/dtmax predicts clinical outcome in patients with cardiac resynchronization therapy. Eur J Heart Fail. 2011;13(10):1126–32.

    PubMed  Google Scholar 

  177. Gold MR, Auricchio A, Hummel JD, Giudici MC, Ding J, Tockman B, Spinelli J. Comparison of stimulation sites within left ventricular veins on the acute hemodynamic effects of cardiac resynchronization therapy. Heart Rhythm. 2005;2(4):376–81.

    PubMed  Google Scholar 

  178. Butter C, Auricchio A, Stellbrink C, Fleck E, Ding J, Yu Y, Huvelle E, Spinelli J, Pacing Therapy for Chronic Heart Failure II Study Group. Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients. Circulation. 2001;104(25):3026–9.

    CAS  PubMed  Google Scholar 

  179. Bogaard MD, Doevendans PA, Leenders GE, Loh P, Hauer RN, van Wessel H, Meine M. Can optimization of pacing settings compensate for a non-optimal left ventricular pacing site? Europace. 2010;12(9):1262–9.

    PubMed  Google Scholar 

  180. Auricchio A, Stellbrink C, Block M, Sack S, Vogt J, Bakker P, Klein H, Kramer A, Ding J, Salo R, Tockman B, Pochet T, Spinelli J. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group. Circulation. 1999;99(23):2993–3001.

    CAS  PubMed  Google Scholar 

  181. Auricchio A, Stellbrink C, Sack S, Block M, Vogt J, Bakker P, Huth C, Schöndube F, Wolfhard U, Böcker D, Krahnefeld O, Kirkels H, Pacing Therapies in Congestive Heart Failure (PATH-CHF) Study Group. Long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay. J Am Coll Cardiol. 2002;39(12):2026–33.

    PubMed  Google Scholar 

  182. van Gelder BM, Bracke FA, Meijer A, Lakerveld LJ, Pijls NH. Effect of optimizing the VV interval on left ventricular contractility in cardiac resynchronization therapy. Am J Cardiol. 2004;93(12):1500–3.

    PubMed  Google Scholar 

  183. Suzuki H, Shimano M, Yoshida Y, Inden Y, Muramatsu T, Tsuji Y, Tsuboi N, Hirayama H, Shibata R, Murohara T. Maximum derivative of left ventricular pressure predicts cardiac mortality after cardiac resynchronization therapy. Clin Cardiol. 2010;33(12):E18–23.

    PubMed  Google Scholar 

  184. de Roest G, Knaapen P, Götte M, Hendriks T, Allaart C, de Cock C, van Rossum A. Stroke work or systolic dP/dtmax to evaluate acute response to cardiac resynchronization therapy: are they interchangeable? Eur J Heart Fail. 2009;11(7):706–8.

    PubMed  Google Scholar 

  185. Kass DA, Maughan WL, Guo ZM, Kono A, Sunagawa K, Sagawa K. Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships. Circulation. 1987;76(6):1422–36.

    CAS  PubMed  Google Scholar 

  186. Kass DA, Chen CH, Curry C, Talbot M, Berger R, Fetics B, Nevo E. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation. 1999;99(12):1567–73.

    CAS  PubMed  Google Scholar 

  187. Crystal E, Ovsyshcher IE. Cardiac output-based versus empirically programmed AV interval–how different are they? Europace. 1999;1(2):121–5.

    CAS  PubMed  Google Scholar 

  188. Ellenbogen KA, Gold MR, Meyer TE, Fernndez Lozano I, Mittal S, Waggoner AD, Lemke B, Singh JP, Spinale FG, Van Eyk JE, Whitehill J, Weiner S, Bedi M, Rapkin J, Stein KM. Primary results from the SmartDelay determined AV optimization: a comparison to other AV delay methods used in cardiac resynchronization therapy (SMART-AV) trial: a randomized trial comparing empirical, echocardiography-guided, and algorithmic atrioventricular delay programming in cardiac resynchronization therapy. Circulation. 2010;122(25):2660–8.

    PubMed  Google Scholar 

  189. Baker 2nd JH, McKenzie 3rd J, Beau S, Greer GS, Porterfield J, Fedor M, Greenberg S, Daoud EG, Corbisiero R, Bailey JR, Porterfield L. Acute evaluation of programmer-guided AV/PV and VV delay optimization comparing an IEGM method and echocardiogram for cardiac resynchronization therapy in heart failure patients and dual-chamber ICD implants. J Cardiovasc Electrophysiol. 2007;18(2):185–91.

    PubMed  Google Scholar 

  190. Abraham WT, Gras D, Yu CM, Guzzo L, Gupta MS, FREEDOM Steering Committee. Rationale and design of a randomized clinical trial to assess the safety and efficacy of frequent optimization of cardiac resynchronization therapy: the Frequent Optimization Study Using the QuickOpt Method (FREEDOM) trial. Am Heart J. 2010;159(6):944–948.e1.

    PubMed  Google Scholar 

  191. Abraham William T, et al. Results from the FREEDOM Trial - Assess the Safety and Efficacy of Frequent Optimization of Cardiac Resynchronization Therapy. SP08. Late-Breaking Clinical Trials. Denver: HRS; 2010.

    Google Scholar 

  192. Porciani MC, Rao CM, Mochi M, Cappelli F, Bongiorno G, Perini AP, Lilli A, Ricciardi G, Hashtroudi L, Silvestri P, Barold SS, Padeletti L. A real-time three-dimensional echocardiographic validation of an intracardiac electrogram-based method for optimizing cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2008;31(1):56–63.

    PubMed  Google Scholar 

  193. Leung SK, Lau CP, Lam CT, Ho S, Tse HF, Yu CM, Lee K, Tang MO, To KM, Renesto F. Automatic optimization of resting and exercise atrioventricular interval using a peak endocardial acceleration sensor: validation with Doppler echocardiography and direct cardiac output measurements. Pacing Clin Electrophysiol. 2000;23(11 Pt 2):1762–6.

    CAS  PubMed  Google Scholar 

  194. Khan FZ, Virdee MS, Pugh PJ, Read PA, Fynn SP, Dutka DP. Non-invasive cardiac output measurements based on bioreactance for optimization of atrio- and interventricular delays. Europace. 2009;11(12):1666–74.

    PubMed  Google Scholar 

  195. Gras D, Gupta MS, Boulogne E, Guzzo L, Abraham WT. Optimization of AV and VV delays in the real-world CRT patient population: an international survey on current clinical practice. Pacing Clin Electrophysiol. 2009;32 Suppl 1:S236–9.

    PubMed  Google Scholar 

  196. Khan FZ, Virdee MS, Hutchinson J, Smith B, Pugh PJ, Read PA, Fynn SP, Dutka DP. Cardiac resynchronization therapy optimization using noninvasive cardiac output measurement. Pacing Clin Electrophysiol. 2011;34(11):1527–36.

    PubMed  Google Scholar 

  197. Ritter P, Delnoy PP, Padeletti L, Lunati M, Naegele H, Borri-Brunetto A, Silvestre J. A randomized pilot study of optimization of cardiac resynchronization therapy in sinus rhythm patients using a peak endocardial acceleration sensor vs. standard methods. Europace. 2012;14(9):1324–33.

    PubMed  Google Scholar 

  198. Keren H, Burkhoff D, Squara P. Evaluation of a noninvasive continuous cardiac output monitoring system based on thoracic bioreactance. Am J Physiol Heart Circ Physiol. 2007;293(1):H583–9.

    CAS  PubMed  Google Scholar 

  199. Rao RK, Kumar UN, Schafer J, Viloria E, De Lurgio D, Foster E. Reduced ventricular volumes and improved systolic function with cardiac resynchronization therapy: a randomized trial comparing simultaneous biventricular pacing, sequential biventricular pacing, and left ventricular pacing. Circulation. 2007;115(16):2136–44.

    PubMed  Google Scholar 

  200. Naqvi TZ, Rafique AM. Novel insights on effect of atrioventricular programming of biventricular pacemaker in heart failure–a case series. Cardiovasc Ultrasound. 2006;4:38.

    PubMed Central  PubMed  Google Scholar 

  201. Stanton T, Hawkins NM, Hogg KJ, Goodfield NE, Petrie MC, McMurray JJ. How should we optimize cardiac resynchronization therapy? Eur Heart J. 2008;29(20):2458–72.

    PubMed  Google Scholar 

  202. Cazeau S, Bordachar P, Jauvert G, Lazarus A, Alonso C, Vandrell MC, Mugica J, Ritter P. Echocardiographic modeling of cardiac dyssynchrony before and during multisite stimulation: a prospective study. Pacing Clin Electrophysiol. 2003;26(1 Pt 2):137–43.

    CAS  PubMed  Google Scholar 

  203. Scharf C, Li P, Muntwyler J, Chugh A, Oral H, Pelosi F, Morady F, Armstrong WF. Rate-dependent AV delay optimization in cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2005;28(4):279–84.

    PubMed  Google Scholar 

  204. O’Donnell D, Nadurata V, Hamer A, Kertes P, Mohamed U. Long-term variations in optimal programming of cardiac resynchronization therapy devices. Pacing Clin Electrophysiol. 2005;28 Suppl 1:S24–6.

    PubMed  Google Scholar 

  205. Kedia N, Ng K, Apperson-Hansen C, Wang C, Tchou P, Wilkoff BL, Grimm RA. Usefulness of atrioventricular delay optimization using Doppler assessment of mitral inflow in patients undergoing cardiac resynchronization therapy. Am J Cardiol. 2006;98(6):780–5.

    PubMed  Google Scholar 

  206. Zhang Q, Fung JW, Chan YS, Chan HC, Lin H, Chan S, Yu CM. The role of repeating optimization of atrioventricular interval during interim and long-term follow-up after cardiac resynchronization therapy. Int J Cardiol. 2008;124(2):211–7.

    PubMed  Google Scholar 

  207. Hardt SE, Yazdi SH, Bauer A, Filusch A, Korosoglou G, Hansen A, Bekeredjian R, Ehlermann P, Remppis A, Katus HA, Kuecherer HF. Immediate and chronic effects of AV-delay optimization in patients with cardiac resynchronization therapy. Int J Cardiol. 2007;115(3):318–25.

    PubMed  Google Scholar 

  208. Auricchio A, Ding J, Spinelli JC, Kramer AP, Salo RW, Hoersch W, KenKnight BH, Klein HU. Cardiac resynchronization therapy restores optimal atrioventricular mechanical timing in heart failure patients with ventricular conduction delay. J Am Coll Cardiol. 2002;39(7):1163–9.

    PubMed  Google Scholar 

  209. Naqvi TZ. Echocardiography-guided biventricular pacemaker optimization. JACC Cardiovasc Imaging. 2010;3(11):1168–80.

    PubMed  Google Scholar 

  210. Sogaard P, Egeblad H, Pedersen AK, Kim WY, Kristensen BO, Hansen PS, Mortensen PT. Sequential versus simultaneous biventricular resynchronization for severe heart failure: evaluation by tissue Doppler imaging. Circulation. 2002;106(16):2078–84.

    PubMed  Google Scholar 

  211. Hay I, Melenovsky V, Fetics BJ, Judge DP, Kramer A, Spinelli J, Reister C, Kass DA, Berger RD. Short-term effects of right-left heart sequential cardiac resynchronization in patients with heart failure, chronic atrial fibrillation, and atrioventricular nodal block. Circulation. 2004;110(22):3404–10.

    PubMed  Google Scholar 

  212. Kurzidim K, Reinke H, Sperzel J, Schneider HJ, Danilovic D, Siemon G, Neumann T, Hamm CW, Pitschner HF. Invasive optimization of cardiac resynchronization therapy: role of sequential biventricular and left ventricular pacing. Pacing Clin Electrophysiol. 2005;28(8):754–61.

    PubMed  Google Scholar 

  213. Burri H, Sunthorn H, Somsen A, Zaza S, Fleury E, Shah D, Righetti A. Optimizing sequential biventricular pacing using radionuclide ventriculography. Heart Rhythm. 2005;2(9):960–5.

    PubMed  Google Scholar 

  214. Whinnett ZI, Davies JE, Willson K, Manisty CH, Chow AW, Foale RA, Davies DW, Hughes AD, Mayet J, Francis DP. Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay. Heart. 2007;92(11):1628–34.

    Google Scholar 

  215. Penicka M, Bartunek J, De Bruyne B, Vanderheyden M, Goethals M, De Zutter M, Brugada P, Geelen P. Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography. Circulation. 2004;109(8):978–83.

    PubMed  Google Scholar 

  216. Weiss R, Malik R, Wish M, Dinerman J, Lee LY, Petrutiu S, Khoo MSC. V-V Optimization in Cardiac Resynchronization Therapy Non-Responders: RESPONSE-HF Trial Results [Abstract]. Heart Rhythm. 2010;7(5 Suppl):S26.

    Google Scholar 

  217. Young JB, Abraham WT, Smith AL, Leon AR, Lieberman R, Wilkoff B, Canby RC, Schroeder JS, Liem LB, Hall S, Wheelan K, Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE ICD) Trial Investigators. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD trial. JAMA. 2003;289(20):2685–94.

    PubMed  Google Scholar 

  218. Cazeau S, Ritter P, Lazarus A, Gras D, Backdach H, Mundler O, Mugica J. Multisite pacing for end-stage heart failure: early experience. Pacing Clin Electrophysiol. 1996;19(11 Pt 2):1748–57.

    CAS  PubMed  Google Scholar 

  219. Leclercq C, Cazeau S, Le Breton H, Ritter P, Mabo P, Gras D, Pavin D, Lazarus A, Daubert JC. Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure. J Am Coll Cardiol. 1998;32(7):1825–31.

    CAS  PubMed  Google Scholar 

  220. Saxon LA, Kerwin WF, Cahalan MK, Kalman JM, Olgin JE, Foster E, Schiller NB, Shinbane JS, Lesh MD, Merrick SH. Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function. J Cardiovasc Electrophysiol. 1998;9(1):13–21.

    CAS  PubMed  Google Scholar 

  221. Gras D, Mabo P, Tang T, Luttikuis O, Chatoor R, Pedersen AK, Tscheliessnigg HH, Deharo JC, Puglisi A, Silvestre J, Kimber S, Ross H, Ravazzi A, Paul V, Skehan D. Multisite pacing as a supplemental treatment of congestive heart failure: preliminary results of the Medtronic Inc. InSync Study. Pacing Clin Electrophysiol. 1998;21(11 Pt 2):2249–55.

    CAS  PubMed  Google Scholar 

  222. Nelson GS, Berger RD, Fetics BJ, Talbot M, Spinelli JC, Hare JM, Kass DA. Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation. 2000;102(25):3053–9.

    CAS  PubMed  Google Scholar 

  223. Gras D, Leclercq C, Tang AS, Bucknall C, Luttikhuis HO, Kirstein-Pedersen A. Cardiac resynchronization therapy in advanced heart failure the multicenter InSync clinical study. Eur J Heart Fail. 2002;4(3):311–20.

    PubMed  Google Scholar 

  224. O’Cochlain B, Delurgio D, Leon A, Langberg J. The effect of variation in the interval between right and left ventricular activation on paced QRS duration. Pacing Clin Electrophysiol. 2001;24(12):1780–2.

    PubMed  Google Scholar 

  225. Jia P, Ramanathan C, Ghanem RN, Ryu K, Varma N, Rudy Y. Electrocardiographic imaging of cardiac resynchronization therapy in heart failure: observation of variable electrophysiologic responses. Heart Rhythm. 2006;3(3):296–310.

    PubMed Central  PubMed  Google Scholar 

  226. Gassis S, León AR. Cardiac resynchronization therapy: strategies for device programming, troubleshooting and follow-up. J Interv Card Electrophysiol. 2005;13(3):209–22.

    PubMed  Google Scholar 

  227. Marcus RH, Harry MJ, Lang RM. Pacemaker therapy in refractory heart failure: a systematic approach to electromechanical optimization of diastolic function. JACC Cardiovasc Imaging. 2009;2(7):908–13.

    PubMed  Google Scholar 

  228. Bader H, Garrigue S, Lafitte S, Reuter S, Jaïs P, Haïssaguerre M, Bonnet J, Clementy J, Roudaut R. Intra-left ventricular electromechanical asynchrony. A new independent predictor of severe cardiac events in heart failure patients. J Am Coll Cardiol. 2004;43(2):248–56.

    PubMed  Google Scholar 

  229. Voigt JU, Schneider TM, Korder S, Szulik M, Gürel E, Daniel WG, Rademakers F, Flachskampf FA. Apical transverse motion as surrogate parameter to determine regional left ventricular function inhomogeneities: a new, integrative approach to left ventricular asynchrony assessment. Eur Heart J. 2009;30(8):959–68.

    PubMed  Google Scholar 

  230. Szulik M, Tillekaerts M, Vangeel V, Ganame J, Willems R, Lenarczyk R, Rademakers F, Kalarus Z, Kukulski T, Voigt JU. Assessment of apical rocking: a new, integrative approach for selection of candidates for cardiac resynchronization therapy. Eur J Echocardiogr. 2010;11(10):863–9.

    PubMed  Google Scholar 

  231. Pitzalis MV, Iacoviello M, Romito R, Guida P, De Tommasi E, Luzzi G, Anaclerio M, Forleo C, Rizzon P. Ventricular asynchrony predicts a better outcome in patients with chronic heart failure receiving cardiac resynchronization therapy. J Am Coll Cardiol. 2005;45(1):65–9.

    PubMed  Google Scholar 

  232. Parsai C, Bijnens B, Sutherland GR, Baltabaeva A, Claus P, Marciniak M, Paul V, Scheffer M, Donal E, Derumeaux G, Anderson L. Toward understanding response to cardiac resynchronization therapy: left ventricular dyssynchrony is only one of multiple mechanisms. Eur Heart J. 2009;30(8):940–9.

    PubMed  Google Scholar 

  233. Yu CM, Fung JW, Zhang Q, Chan CK, Chan YS, Lin H, Kum LC, Kong SL, Zhang Y, Sanderson JE. Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and nonischemic heart failure after cardiac resynchronization therapy. Circulation. 2004;110(1):66–73.

    PubMed  Google Scholar 

  234. Yu CM, Fung WH, Lin H, Zhang Q, Sanderson JE, Lau CP. Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol. 2003;91(6):684–8.

    PubMed  Google Scholar 

  235. Lim P, Buakhamsri A, Popovic ZB, Greenberg NL, Patel D, Thomas JD, Grimm RA. Longitudinal strain delay index by speckle tracking imaging: a new marker of response to cardiac resynchronization therapy. Circulation. 2008;118(11):1130–7.

    PubMed  Google Scholar 

  236. Kapetanakis S, Kearney MT, Siva A, Gall N, Cooklin M, Monaghan MJ. Real-time three-dimensional echocardiography: a novel technique to quantify global left ventricular mechanical dyssynchrony. Circulation. 2005;112(7):992–1000.

    CAS  PubMed  Google Scholar 

  237. Marsan NA, Bleeker GB, Ypenburg C, Ghio S, van de Veire NR, Holman ER, van der Wall EE, Tavazzi L, Schalij MJ, Bax JJ. Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. J Cardiovasc Electrophysiol. 2008;19(4):392–9.

    PubMed  Google Scholar 

  238. Gorcsan 3rd J, Tanabe M, Bleeker GB, Suffoletto MS, Thomas NC, Saba S, Tops LF, Schalij MJ, Bax JJ. Combined longitudinal and radial dyssynchrony predicts ventricular response after resynchronization therapy. J Am Coll Cardiol. 2007;50(15):1476–83.

    PubMed  Google Scholar 

  239. Van de Veire NR, Bleeker GB, Ypenburg C, De Sutter J, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ. Usefulness of triplane tissue Doppler imaging to predict acute response to cardiac resynchronization therapy. Am J Cardiol. 2007;100(3):476–82.

    PubMed  Google Scholar 

  240. Beshai JF, Grimm RA, Nagueh SF, Baker 2nd JH, Beau SL, Greenberg SM, Pires LA, Tchou PJ, RethinQ Study Investigators. Cardiac-resynchronization therapy in heart failure with narrow QRS complexes. N Engl J Med. 2007;357(24):2461–71.

    CAS  PubMed  Google Scholar 

  241. Oyenuga O, Hara H, Tanaka H, Kim HN, Adelstein EC, Saba S, Gorcsan 3rd J. Usefulness of echocardiographic dyssynchrony in patients with borderline QRS duration to assist with selection for cardiac resynchronization therapy. JACC Cardiovasc Imaging. 2010;3(2):132–40.

    PubMed  Google Scholar 

  242. Miyazaki C, Powell BD, Bruce CJ, Espinosa RE, Redfield MM, Miller FA, Hayes DL, Cha YM, Oh JK. Comparison of echocardiographic dyssynchrony assessment by tissue velocity and strain imaging in subjects with or without systolic dysfunction and with or without left bundle-branch block. Circulation. 2008;117(20):2617–25.

    PubMed  Google Scholar 

  243. Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G, Galderisi M, Marwick T, Nagueh SF, Sengupta PP, Sicari R, Smiseth OA, Smulevitz B, Takeuchi M, Thomas JD, Vannan M, Voigt JU, Zamorano JL. Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese society of echocardiography. J Am Soc Echocardiogr. 2011;24(3):277–313.

    PubMed  Google Scholar 

  244. Søgaard P, Egeblad H, Kim WY, Jensen HK, Pedersen AK, Kristensen BØ, Mortensen PT. Tissue Doppler imaging predicts improved systolic performance and reversed left ventricular remodeling during long-term cardiac resynchronization therapy. J Am Coll Cardiol. 2002;40(4):723–30.

    PubMed  Google Scholar 

  245. Breithardt OA, Stellbrink C, Kramer AP, Sinha AM, Franke A, Salo R, Schiffgens B, Huvelle E, Auricchio A, PATH-CHF Study Group. Pacing therapies for congestive heart failure. Echocardiographic quantification of left ventricular asynchrony predicts an acute hemodynamic benefit of cardiac resynchronization therapy. J Am Coll Cardiol. 2002;40(3):536–45.

    PubMed  Google Scholar 

  246. Breithardt OA, Stellbrink C, Herbots L, Claus P, Sinha AM, Bijnens B, Hanrath P, Sutherland GR. Cardiac resynchronization therapy can reverse abnormal myocardial strain distribution in patients with heart failure and left bundle branch block. J Am Coll Cardiol. 2003;42(3):486–94.

    PubMed  Google Scholar 

  247. Yu CM, Bleeker GB, Fung JW, Schalij MJ, Zhang Q, van der Wall EE, Chan YS, Kong SL, Bax JJ. Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy. Circulation. 2005;112(11):1580–6.

    PubMed  Google Scholar 

  248. Sweeney MO, Prinzen FW. Ventricular pump function and pacing: physiological and clinical integration. Circ Arrhythm Electrophysiol. 2008;1(2):127–39.

    PubMed  Google Scholar 

  249. Tops LF, Schalij MJ, Bax JJ. The effects of right ventricular apical pacing on ventricular function and dyssynchrony implications for therapy. J Am Coll Cardiol. 2009;54(9):764–76.

    PubMed  Google Scholar 

  250. Manolis AS. The deleterious consequences of right ventricular apical pacing: time to seek alternate site pacing. Pacing Clin Electrophysiol. 2006;29(3):298–315.

    PubMed  Google Scholar 

  251. Sweeney MO, Hellkamp AS, Ellenbogen KA, Greenspon AJ, Freedman RA, Lee KL, Lamas GA, MOde Selection Trial Investigators. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2003;107(23):2932–7.

    PubMed  Google Scholar 

  252. Leclercq C, Walker S, Linde C, Clementy J, Marshall AJ, Ritter P, Djiane P, Mabo P, Levy T, Gadler F, Bailleul C, Daubert JC. Comparative effects of permanent biventricular and right-univentricular pacing in heart failure patients with chronic atrial fibrillation. Eur Heart J. 2002;23(22):1780–7.

    CAS  PubMed  Google Scholar 

  253. Brignole M, Gammage M, Puggioni E, Alboni P, Raviele A, Sutton R, Vardas P, Bongiorni MG, Bergfeldt L, Menozzi C, Musso G, Optimal Pacing SITE (OPSITE) Study Investigators. Comparative assessment of right, left, and biventricular pacing in patients with permanent atrial fibrillation. Eur Heart J. 2005;26(7):712–22.

    CAS  PubMed  Google Scholar 

  254. Doshi RN, Daoud EG, Fellows C, Turk K, Duran A, Hamdan MH, Pires LA, PAVE Study Group. Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (the PAVE study). J Cardiovasc Electrophysiol. 2005;16(11):1160–5.

    PubMed  Google Scholar 

  255. Kindermann M, Hennen B, Jung J, Geisel J, Böhm M, Fröhlig G. Biventricular versus conventional right ventricular stimulation for patients with standard pacing indication and left ventricular dysfunction: the Homburg Biventricular Pacing Evaluation (HOBIPACE). J Am Coll Cardiol. 2006;47(10):1927–37.

    PubMed  Google Scholar 

  256. Albertsen AE, Nielsen JC, Poulsen SH, Mortensen PT, Pedersen AK, Hansen PS, Jensen HK, Egeblad H. Biventricular pacing preserves left ventricular performance in patients with high-grade atrio-ventricular block: a randomized comparison with DDD(R) pacing in 50 consecutive patients. Europace. 2008;10(3):314–20.

    PubMed  Google Scholar 

  257. Tops LF, Suffoletto MS, Bleeker GB, Boersma E, van der Wall EE, Gorcsan 3rd J, Schalij MJ, Bax JJ. Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing. J Am Coll Cardiol. 2007;50(12):1180–8.

    PubMed  Google Scholar 

  258. Leon AR, Greenberg JM, Kanuru N, Baker CM, Mera FV, Smith AL, Langberg JJ, DeLurgio DB. Cardiac resynchronization in patients with congestive heart failure and chronic atrial fibrillation: effect of upgrading to biventricular pacing after chronic right ventricular pacing. J Am Coll Cardiol. 2002;39(8):1258–63.

    PubMed  Google Scholar 

  259. Witte KK, Pipes RR, Nanthakumar K, Parker JD. Biventricular pacemaker upgrade in previously paced heart failure patients–improvements in ventricular dyssynchrony. J Card Fail. 2006;12(3):199–204.

    PubMed  Google Scholar 

  260. Valls-Bertault V, Fatemi M, Gilard M, Pennec PY, Etienne Y, Blanc JJ. Assessment of upgrading to biventricular pacing in patients with right ventricular pacing and congestive heart failure after atrioventricular junctional ablation for chronic atrial fibrillation. Europace. 2004;6(5):438–43.

    PubMed  Google Scholar 

  261. Eldadah ZA, Rosen B, Hay I, Edvardsen T, Jayam V, Dickfeld T, Meininger GR, Judge DP, Hare J, Lima JB, Calkins H, Berger RD. The benefit of upgrading chronically right ventricle-paced heart failure patients to resynchronization therapy demonstrated by strain rate imaging. Heart Rhythm. 2006;3(4):435–42.

    PubMed  Google Scholar 

  262. Marai I, Gurevitz O, Carasso S, Nof E, Bar-Lev D, Luria D, Arbel Y, Freimark D, Feinberg MS, Eldar M, Glikson M. Improvement of congestive heart failure by upgrading of conventional to resynchronization pacemakers. Pacing Clin Electrophysiol. 2006;29(8):880–4.

    PubMed  Google Scholar 

  263. Leclercq C, Cazeau S, Lellouche D, Fossati F, Anselme F, Davy JM, Sadoul N, Klug D, Mollo L, Daubert JC. Upgrading from single chamber right ventricular to biventricular pacing in permanently paced patients with worsening heart failure: the RD-CHF study. Pacing Clin Electrophysiol. 2007;30 Suppl 1:S23–30.

    PubMed  Google Scholar 

  264. Wilkoff BL, Cook JR, Epstein AE, Greene HL, Hallstrom AP, Hsia H, Kutalek SP, Sharma A, Dual Chamber and VVI Implantable Defibrillator Trial Investigators. Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA. 2002;288(24):3115–23.

    PubMed  Google Scholar 

  265. Thambo JB, Bordachar P, Garrigue S, Lafitte S, Sanders P, Reuter S, Girardot R, Crepin D, Reant P, Roudaut R, Jaïs P, Haïssaguerre M, Clementy J, Jimenez M. Detrimental ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical pacing. Circulation. 2004;110(25):3766–72.

    PubMed  Google Scholar 

  266. Tops LF, Schalij MJ, Holman ER, van Erven L, van der Wall EE, Bax JJ. Right ventricular pacing can induce ventricular dyssynchrony in patients with atrial fibrillation after atrioventricular node ablation. J Am Coll Cardiol. 2006;48(8):1642–8.

    PubMed  Google Scholar 

  267. Yu CC, Liu YB, Lin MS, Wang JY, Lin JL, Lin LC. Septal pacing preserving better left ventricular mechanical performance and contractile synchronism than apical pacing in patients implanted with an atrioventricular sequential dual chamber pacemaker. Int J Cardiol. 2007;118(1):97–106.

    PubMed  Google Scholar 

  268. Kypta A, Steinwender C, Kammler J, Leisch F, Hofmann R. Long-term outcomes in patients with atrioventricular block undergoing septal ventricular lead implantation compared with standard apical pacing. Europace. 2008;10(5):574–9.

    PubMed  Google Scholar 

  269. Victor F, Mabo P, Mansour H, Pavin D, Kabalu G, de Place C, Leclercq C, Daubert JC. A randomized comparison of permanent septal versus apical right ventricular pacing: short-term results. J Cardiovasc Electrophysiol. 2006;17(3):238–42.

    PubMed  Google Scholar 

  270. Zanon F, Bacchiega E, Rampin L, Aggio S, Baracca E, Pastore G, Marotta T, Corbucci G, Roncon L, Rubello D, Prinzen FW. Direct His bundle pacing preserves coronary perfusion compared with right ventricular apical pacing: a prospective, cross-over mid-term study. Europace. 2008;10(5):580–7.

    PubMed  Google Scholar 

  271. Occhetta E, Bortnik M, Magnani A, Francalacci G, Piccinino C, Plebani L, Marino P. Prevention of ventricular desynchronization by permanent para-Hisian pacing after atrioventricular node ablation in chronic atrial fibrillation: a crossover, blinded, randomized study versus apical right ventricular pacing. J Am Coll Cardiol. 2006;47(10):1938–45.

    PubMed  Google Scholar 

  272. de Cock CC, Giudici MC, Twisk JW. Comparison of the haemodynamic effects of right ventricular outflow-tract pacing with right ventricular apex pacing: a quantitative review. Europace. 2003;5(3):275–8.

    PubMed  Google Scholar 

  273. Vanerio G, Vidal JL, Fernández Banizi P, Banina Aguerre D, Viana P, Tejada J. Medium- and long-term survival after pacemaker implant: improved survival with right ventricular outflow tract pacing. J Interv Card Electrophysiol. 2008;21(3):195–201.

    PubMed  Google Scholar 

  274. ten Cate TJ, Scheffer MG, Sutherland GR, Verzijlbergen JF, van Hemel NM. Right ventricular outflow and apical pacing comparably worsen the echocardiographic normal left ventricle. Eur J Echocardiogr. 2008;9(5):672–7.

    PubMed  Google Scholar 

  275. Clay SC. Alternate site biventricular pacing: Bi-V in the RV–is there a role? Pacing Clin Electrophysiol. 2004;27(5):567–9.

    Google Scholar 

  276. Pachón JC, Pachón EI, Albornoz RN, Pachón JC, Kormann DS, Gimenes VM, Medeiros PT, Silva MA, Sousa JE, Paulista PP, Souza LC, Jatene AD. Ventricular endocardial right bifocal stimulation in the treatment of severe dilated cardiomyopathy heart failure with wide QRS. Pacing Clin Electrophysiol. 2001;24(9 Pt 1):1369–76.

    PubMed  Google Scholar 

  277. O’Donnell D, Nadurata V, Hamer A, Kertes P, Mohamed U. Bifocal right ventricular cardiac resynchronization therapies in patients with unsuccessful percutaneous lateral left ventricular venous access. Pacing Clin Electrophysiol. 2005;28 Suppl 1:S27–30.

    PubMed  Google Scholar 

  278. Stambler BS, Ellenbogen K, Zhang X, Porter TR, Xie F, Malik R, Small R, Burke M, Kaplan A, Nair L, Belz M, Fuenzalida C, Gold M, Love C, Sharma A, Silverman R, Sogade F, Van Natta B, Wilkoff BL, ROVA Investigators. Right ventricular outflow versus apical pacing in pacemaker patients with congestive heart failure and atrial fibrillation. J Cardiovasc Electrophysiol. 2003;14(11):1180–6.

    PubMed  Google Scholar 

  279. Zamparelli L, Martiniello AR. Right ventricular bifocal DDD pacing as primary choice for cardiac resynchronization in heart failure patients with severe mitral regurgitation (abstr). Heart Rhythm. 2005;2(Suppl):S250.

    Google Scholar 

  280. Aonuma K, Yokoyama Y, Seo Y, et al. Tri-ventricular pacing: a novel concept of resynchronization therapy for better left ventricular performance in end-stage heart failure (abstract). Heart Rhythm. 2005;2(Suppl):S131.

    Google Scholar 

  281. Yoshida K, Seo Y, Yamasaki H, Tanoue K, Murakoshi N, Ishizu T, Sekiguchi Y, Kawano S, Otsuka S, Watanabe S, Yamaguchi I, Aonuma K. Effect of triangle ventricular pacing on haemodynamics and dyssynchrony in patients with advanced heart failure: a comparison study with conventional bi-ventricular pacing therapy. Eur Heart J. 2007;28(21):2610–9.

    PubMed  Google Scholar 

  282. Singh JP, Klein HU, Huang DT, Reek S, Kuniss M, Quesada A, Barsheshet A, Cannom D, Goldenberg I, McNitt S, Daubert JP, Zareba W, Moss AJ. Left ventricular lead position and clinical outcome in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT) trial. Circulation. 2011;123(11):1159–66.

    PubMed  Google Scholar 

  283. Derval N, Jaïs P. Optimizing hemodynamics in cardiac resynchronization therapy by left ventricular pacing site: you find only what you are looking for. J Am Coll Cardiol. 2010;56(10):782–3.

    PubMed  Google Scholar 

  284. Peichl P, Kautzner J. Variable patterns of septal activation in patients with left bundle branch block and heart failure. J Cardiovasc Electrophysiol. 2003;14(8):900. author reply 900–1.

    PubMed  Google Scholar 

  285. Bordachar P, Labrousse L, Thambo JB, Reant P, Lafitte S, O’Neill MD, Jais P, Haissaguerre M, Clementy J, Dos Santos P. Haemodynamic impact of the left ventricular pacing site during graded ischaemia in an open-chest pig model. Europace. 2008;10(2):242–8.

    PubMed  Google Scholar 

  286. Murphy RT, Sigurdsson G, Mulamalla S, Agler D, Popovic ZB, Starling RC, Wilkoff BL, Thomas JD, Grimm RA. Tissue synchronization imaging and optimal left ventricular pacing site in cardiac resynchronization therapy. Am J Cardiol. 2006;97(11):1615–21.

    PubMed  Google Scholar 

  287. Ansalone G, Giannantoni P, Ricci R, Trambaiolo P, Fedele F, Santini M. Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing. J Am Coll Cardiol. 2002;39(3):489–99.

    PubMed  Google Scholar 

  288. Buck S, Maass AH, van Veldhuisen DJ, Van Gelder IC. Cardiac resynchronisation therapy and the role of optimal device utilisation. Neth Heart J. 2009;17(9):354–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  289. Bank AJ, Burns KV, Gage RM. Echocardiographic measurement of mechanical dyssynchrony in heart failure and cardiac resynchronization therapy. US Cardiology. 2010;7(1):24–32.

    Google Scholar 

  290. Saba S, Schwartzman D, Jain S, et al. A prospective randomized controlled study of echocardiographic-guided lead placement for cardiac resynchronization therapy: Results of the STARTER trial. Heart Rhythm Society 2012 Scientific Sessions, Boston, MA, May 11, 2012, . Abstract LB02-5.

    Google Scholar 

  291. Dekker AL, Phelps B, Dijkman B, van der Nagel T, van der Veen FH, Geskes GG, Maessen JG. Epicardial left ventricular lead placement for cardiac resynchronization therapy: optimal pace site selection with pressure-volume loops. J Thorac Cardiovasc Surg. 2004;127(6):1641–7.

    CAS  PubMed  Google Scholar 

  292. Helm RH, Byrne M, Helm PA, Daya SK, Osman NF, Tunin R, Halperin HR, Berger RD, Kass DA, Lardo AC. Three-dimensional mapping of optimal left ventricular pacing site for cardiac resynchronization. Circulation. 2007;115(8):953–61.

    PubMed  Google Scholar 

  293. Khan FZ, Virdee MS, Palmer CR, Pugh PJ, O’Halloran D, Elsik M, Read PA, Begley D, Fynn SP, Dutka DP. Targeted left ventricular lead placement to guide cardiac resynchronization therapy: the TARGET study: a randomized, controlled trial. J Am Coll Cardiol. 2012;59(17):1509–18.

    PubMed  Google Scholar 

  294. Wikstrom G, Blomström-Lundqvist C, Andren B, Lönnerholm S, Blomström P, Freemantle N, Remp T, Cleland JG, CARE-HF study investigators. The effects of aetiology on outcome in patients treated with cardiac resynchronization therapy in the CARE-HF trial. Eur Heart J. 2009;30(7):782–8.

    PubMed Central  PubMed  Google Scholar 

  295. Ypenburg C, Roes SD, Bleeker GB, Kaandorp TA, de Roos A, Schalij MJ, van der Wall EE, Bax JJ. Effect of total scar burden on contrast-enhanced magnetic resonance imaging on response to cardiac resynchronization therapy. Am J Cardiol. 2007;99(5):657–60.

    PubMed  Google Scholar 

  296. Bertini M, Delgado V, den Uijl DW, Nucifora G, Ng AC, van Bommel RJ, Borleffs CJ, Boriani G, Schalij MJ, Bax JJ. Prediction of cardiac resynchronization therapy response: value of calibrated integrated backscatter imaging. Circ Cardiovasc Imaging. 2010;3(1):86–93.

    PubMed  Google Scholar 

  297. Germano G, Berman DS. Quantitative gated SPECT. J Nucl Med. 2001;42(3):528–9.

    CAS  PubMed  Google Scholar 

  298. Klein C, Nekolla SG, Bengel FM, Momose M, Sammer A, Haas F, Schnackenburg B, Delius W, Mudra H, Wolfram D, Schwaiger M. Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: comparison with positron emission tomography. Circulation. 2002;105(2):162–7.

    PubMed  Google Scholar 

  299. Nekolla SG, Miethaner C, Nguyen N, Ziegler SI, Schwaiger M. Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography. Eur J Nucl Med. 1998;25(9):1313–21.

    CAS  PubMed  Google Scholar 

  300. Van de Veire NR, Schuijf JD, De Sutter J, Devos D, Bleeker GB, de Roos A, van der Wall EE, Schalij MJ, Bax JJ. Non-invasive visualization of the cardiac venous system in coronary artery disease patients using 64-slice computed tomography. J Am Coll Cardiol. 2006;48(9):1832–8.

    PubMed  Google Scholar 

  301. Lozano I, Bocchiardo M, Achtelik M, Gaita F, Trappe HJ, Daoud E, Hummel J, Duby C, Yong P, VENTAK CHF/CONTAK CD Investigators Study Group. Impact of biventricular pacing on mortality in a randomized crossover study of patients with heart failure and ventricular arrhythmias. Pacing Clin Electrophysiol. 2000;23(11 Pt 2):1711–2.

    CAS  PubMed  Google Scholar 

  302. Derval N, Steendijk P, Gula LJ, Deplagne A, Laborderie J, Sacher F, Knecht S, Wright M, Nault I, Ploux S, Ritter P, Bordachar P, Lafitte S, Réant P, Klein GJ, Narayan SM, Garrigue S, Hocini M, Haissaguerre M, Clementy J, Jaïs P. Optimizing hemodynamics in heart failure patients by systematic screening of left ventricular pacing sites: the lateral left ventricular wall and the coronary sinus are rarely the best sites. J Am Coll Cardiol. 2010;55(6):566–75.

    PubMed  Google Scholar 

  303. Singh JP, Fan D, Heist EK, Alabiad CR, Taub C, Reddy V, Mansour M, Picard MH, Ruskin JN, Mela T. Left ventricular lead electrical delay predicts response to cardiac resynchronization therapy. Heart Rhythm. 2006;3(11):1285–92.

    PubMed  Google Scholar 

  304. Delgado V, van Bommel RJ, Bertini M, Borleffs CJ, Marsan NA, Arnold CT, Nucifora G, van de Veire NR, Ypenburg C, Boersma E, Holman ER, Schalij MJ, Bax JJ. Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict long-term survival of ischemic heart failure patients undergoing cardiac resynchronization therapy. Circulation. 2011;123(1):70–8.

    PubMed  Google Scholar 

  305. Becker M, Kramann R, Franke A, Breithardt OA, Heussen N, Knackstedt C, Stellbrink C, Schauerte P, Kelm M, Hoffmann R. Impact of left ventricular lead position in cardiac resynchronization therapy on left ventricular remodelling. A circumferential strain analysis based on 2D echocardiography. Eur Heart J. 2007;28(10):1211–20.

    PubMed  Google Scholar 

  306. Becker M, Franke A, Breithardt OA, Ocklenburg C, Kaminski T, Kramann R, Knackstedt C, Stellbrink C, Hanrath P, Schauerte P, Hoffmann R. Impact of left ventricular lead position on the efficacy of cardiac resynchronisation therapy: a two-dimensional strain echocardiography study. Heart. 2007;93(10):1197–203.

    PubMed Central  PubMed  Google Scholar 

  307. Leyva F, Foley PW, Chalil S, Ratib K, Smith RE, Prinzen F, Auricchio A. Cardiac resynchronization therapy guided by late gadolinium-enhancement cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2011;13:29.

    PubMed Central  PubMed  Google Scholar 

  308. Shetty AK, Duckett SG, Bostock J, Rosenthal E, Rinaldi CA. Use of a quadripolar left ventricular lead to achieve successful implantation in patients with previous failed attempts at cardiac resynchronization therapy. Europace. 2011;13(7):992–6.

    PubMed Central  PubMed  Google Scholar 

  309. Hussain MA, Bhamra-Ariza P, Jacques A, Wilkinson P, Odemuyiwa O, Fluck D, Beeton I, Kaba RA. Benefits of a quadripolar left ventricular lead in patients undergoing cardiac resynchronization therapy with underlying myocardial scar. Pacing Clin Electrophysiol. 2013;36(2):e45–7.

    PubMed  Google Scholar 

  310. Sperzel J, Dänschel W, Gutleben KJ, Kranig W, Mortensen P, Connelly D, Trappe HJ, Seidl K, Duray G, Pieske B, Stockinger J, Boriani G, Jung W, Schilling R, Saberi L, Hallier B, Simon M, Rinaldi CA. First prospective, multi-centre clinical experience with a novel left ventricular quadripolar lead. Europace. 2012;14(3):365–72.

    PubMed  Google Scholar 

  311. Forleo GB, Della Rocca DG, Papavasileiou LP, Molfetta AD, Santini L, Romeo F. Left ventricular pacing with a new quadripolar transvenous lead for CRT: early results of a prospective comparison with conventional implant outcomes. Heart Rhythm. 2011;8(1):31–7.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Medicine, “Acad. Vasile Candea” Emergency Clinical Center for Cardiovascular Diseases, “Titu Maiorescu” University, Calea Plevnei 134, Bucharest, Romania

    Gabriel Cristian MD, PhD, FESC & Liviu Chiriac MD, PhD, FESC

  2. “Prof. Dr. C.C. Iliescu” Institute for Cardiovascular Diseases, Sos. Fundeni 258, Bucharest, Romania

    Ecaterina Bontas MD & Silviu Ionel Dumitrescu MD, PhD

  3. Faculty of Medicine, “Acad. Vasile Candea” Emergency Clinical Center for Cardiovascular Diseases, “Carol Davila” University of Medicine and Pharmacy, “Titu Maiorescu” University, Calea Plevnei 134, Bucharest, Romania

    Ion C. T¸intoiu MD, PhD, FESC

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  1. Gabriel Cristian MD, PhD, FESC
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  2. Ecaterina Bontas MD
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  3. Liviu Chiriac MD, PhD, FESC
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  4. Silviu Ionel Dumitrescu MD, PhD
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  5. Ion C. T¸intoiu MD, PhD, FESC
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Correspondence to Ion C. T¸intoiu MD, PhD, FESC .

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Editors and Affiliations

  1. Department of Cardiology, Center Hospitalier Coutances, Coutances, France

    Ambrose S. Kibos

  2. Department of Internal Medicine Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    Bradley P. Knight

  3. Division of Cardiology, McGill University Health Center, Montreal, Québec, Canada

    Vidal Essebag

  4. Department of Cardiology, Miami Children's Hospital, Miami, Florida, USA

    Steven B. Fishberger

  5. School of Biology, Chemistry and Health, Manchester Metropolitan University, Manchester, United Kingdom

    Mark Slevin

  6. “Acad. Vasile Candea” Emergency Clinical Center for Cardiovascular Diseases, “Carol Davila” University of Medicine and Pharmacy, “Titu Maiorescu” University Faculty of Medicine,, Bucharest, Romania

    Ion C. Țintoiu

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Cristian, G., Bontas, E., Chiriac, L., Dumitrescu, S.I., T¸intoiu, I.C. (2014). Strategies for Restoring Cardiac Synchrony by Cardiac Pacing. In: Kibos, A., Knight, B., Essebag, V., Fishberger, S., Slevin, M., Țintoiu, I. (eds) Cardiac Arrhythmias. Springer, London. https://doi.org/10.1007/978-1-4471-5316-0_44

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